Background
Methods
Aim and study design
Patient selection
Diagnostic procedures
Pathological diagnosis
Comparison of small biopsy samples and surgical specimens
Statistical analysis
Results
Biopsy Methods | ||||
---|---|---|---|---|
TBB (BF: P260F) | TBB (BF: 1 T260) | TBNA | Core-needle (CT or US) | |
Patients | 84 | 26 | 23 | 20 |
Age | ||||
Mean | 73.4 | 68.6 | 68.3 | 65.9 |
Range | 49–88 | 45–84 | 48–88 | 42–93 |
Sex | ||||
Male | 56 | 20 | 16 | 14 |
Female | 28 | 6 | 7 | 6 |
Smoking status | ||||
Current/Ex | 70 | 23 | 21 | 18 |
Never | 14 | 3 | 2 | 2 |
Pathological subtypes | ||||
Adeno | 59 | 7 | 13 | 12 |
Squamous | 23 | 18 | 9 | 5 |
Others | 2 | 1 | 1 | 3 |
TBB (BF: P260F) | TBB (BF: 1 T260) | TBNA | Core-needle (CT or US) | |
---|---|---|---|---|
Sample number | 84 | 26 | 23 | 20 |
Tumor cell counts | ||||
<100 | 11 | 0 | 0 | 0 |
100≦, <1000 | 56 | 3 | 14 | 3 |
1000≦, <2000 | 14 | 3 | 0 | 5 |
2000< | 3 | 20 | 9 | 12 |
Median | 559 | 6953 | 1968 | 6593 |
Range | 30–3000 | 380–30,000 | 100–9000 | 100–37,500 |
Crush artifact or necrotic change, % | ||||
<5 | 15 | 17 | 12 | 14 |
5–50 | 39 | 6 | 8 | 4 |
50< | 30 | 3 | 3 | 2 |
Diameter of biopsy sample, mm, mean (95% C.I.) | ||||
Major axis | 1.3 (±0.1) | 3.2 (±0.9) | 1.6 (±0.4) | 6.3 (±1.7) |
Minor axis | 1.0 (±0.1) | 2.2 (±0.6) | 1.3 (±0.4) | 1.1 (±0.8) |
P-value | ||
---|---|---|
tumor cell count | sample size | |
BF P260F vs 1 T260 | p < 0.0001 | p < 0.0001 |
BF P260F vs TBNA | p = 0.0128 | p = 0.2317 |
BF P260F vs core needle | p < 0.0001 | p < 0.0001 |
BF 1 T260 vs TBNA | p = 0.0004 | p < 0.0001 |
BF 1 T260 vs core needle | p = 0.7229 | p = 0.0027 |
TBNA vs core needle | p = 0.0057 | p < 0.0001 |
TPS | ||||
---|---|---|---|---|
high | low | no | undiagnosed | |
Adenocarcinoma | ||||
StageI, II | 5 | 11 | 15 | 0 |
(%) | 16.1 | 35.5 | 48.4 | 0 |
StageIII, IV | 20 | 15 | 21 | 2 |
(%) | 34.5 | 25.9 | 36.2 | 3.5 |
Squamous cell carcinoma | ||||
StageI, II | 6 | 6 | 4 | 1 |
(%) | 35.3 | 35.3 | 23.5 | 5.9 |
StageIII, IV | 12 | 14 | 7 | 1 |
(%) | 35.3 | 41.2 | 20.6 | 2.9 |
Case | Sex | Smoking | Location | Pathology (dominant %) | Size of lesion (mm) | SUV max | BF | Tumor cell count for BF | TPS in BF (%) | TPS in operation (%) |
---|---|---|---|---|---|---|---|---|---|---|
1 | F | never | Ling | Ad (papi 85) | 24 × 20 | 4.0 | P260F | 700 | 0 | 10 |
2 | M | former | RL | Ad (acinar 70) | 17 × 13 | 4.0 | P260F | 160 | 0 | 0 |
3 | M | former | Ling | Ad (enteric) | 18 × 18 | 5.6 | P260F | 600 | 0 | 10 |
4 | M | current | LL | Pleomorphic | 40 × 28 | 8.1 | P260F | 500 | 50 | 100 |
5 | M | current | RL | Sq | 40 × 35 | 13.4 | P260F | 400 | 20 | 30 |
6 | F | never | LU | Ad (lepidic 90) | 17 × 16 | 4.1 | P260F | 140 | 70 | 70 |
7 | F | former | LU | Ad (papi 70) | 25 × 22 | 4.6 | P260F | 1200 | 0 | 10 |
8 | M | former | RU | Ad (lepi/aci 60/30) | 27 × 25 | 20.4 | P260F | 800 | 0 | 0 |
9 | F | never | LU | Ad (solid/lepi 60/30) | 25 × 18 | 9.4 | P260F | 70 | 50 | 0 |
10 | F | never | LL | Ad (lepi/aci/papi 50/20/20) | 25 × 25 | 3.9 | P260F | 280 | 0 | 0 |
11 | M | former | LL | Ad (papi 60) | 18 × 16 | 6.3 | P260F | 220 | 50 | 30 |
12 | F | former | RU | Ad (papi/lepi 90/10) | 15 × 12 | 3.1 | P260F | 170 | 0 | 0 |
13 | M | former | LL | Ad (solid 100) | 43 × 40 | 11 | P260F | 160 | 90 | 100 |
14 | F | never | LU | Ad (aci/lepi/papi/micropapi 40/20/20/20) | 18 × 17 | 2.2 | P260F | 120 | 40 | 10 |
15 | M | former | RU | Ad (papi/lepi/solid 30/10/10) | 27 × 24 | 2.9 | P260F | 340 | 20 | 10 |
16 | M | former | LU | Ad (solid//papi/aci 50/30/20) | 26 × 12 | 3.2 | P260F | 220 | 0 | 0 |
17 | M | former | RU | Ad (aci/lepi/papi 65/30/5) | 36 × 20 | 5.3 | P260F | 530 | 30 | 30 |
18 | M | former | RL | Mucinous | 64 × 29 | 9.3 | P260F | 450 | 0 | 0 |
19 | M | former | LU | Squamous | 20 × 15 | 8 | P260F | 450 | 30 | 10 |
20 | F | former | RU | Squamous | 12 × 8 | 14.2 | P260F | 1000 | 0 | 0 |
21 | M | never | RU | Ad (papi/aci/lepi/micropapi 60/20/10/10) | 33 × 20 | 3.4 | P260F | 100 | 0 | 10 |
22 | M | former | RU | Ad (papi/lepi 60/40) | 35 × 25 | 6 | P260F | 100 | 30 | 0 |
23 | F | former | RM | Ad (papi/lepi/aci 60/20/20) | 23 × 18 | 3.8 | P260F | 700 | 0 | 10 |
24 | M | former | RU | Ad (micropapi/aci/papi/lepi 50/20/20/10) | 13 × 13 | 3.1 | P260F | 600 | 10 | 20 |
25 | M | former | LU | Mucinous | 25 × 23 | 1.7 | P260F | 200 | 10 | 0 |
26 | M | former | RM | Large | 30 × 25 | 4.8 | P260F | 200 | 70 | 90 |
27 | M | former | RU | Mucinous | 70 × 35 | 8.2 | P260F | 300 | 0 | 0 |
28 | M | former | RU | Squamous | 45 × 20 | 7 | P260F | 350 | 0 | 0 |
29 | F | former | RU | Ad (solid/papi 80/20) | 45 × 38 | 14.1 | P260F | 1000 | 20 | 0 |
30 | F | former | LU | Squamous | 50 × 30 | 4.8 | P260F | 50 | 0 | 10 |