Background
Methods
Data source
Identification of DEGs
Functional enrichment analysis
PPI network construction
Prediction of DEG regulators
Construction of an integrated network
Data validation
Results
Identification and characterization of DEGs
Analysis of the PPI network and modules
Prediction of regulatory TFs and miRNAs
TF | Target | Score | TF | Target | Score |
---|---|---|---|---|---|
ADARB1
|
ATP2B2
| 0.0431271 |
LCP2
|
AIF1
| 0.0485591 |
ADARB1
|
C17orf51
| 0.0453939 |
LCP2
|
APBB1IP
| 0.0500103 |
ADARB1
|
ICMT
| 0.0576544 |
LCP2
|
CCL4
| 0.0490895 |
ADARB1
|
LMAN1
| 0.0474452 |
LCP2
|
CSF2RB
| 0.0501211 |
ADARB1
|
RPLP1
| 0.0452993 |
LCP2
|
EVI2B
| 0.0544675 |
ADARB1
|
SULT1C2
| 0.0493526 |
LCP2
|
MNDA
| 0.0509129 |
APBB1IP
|
AIF1
| 0.0558902 |
LCP2
|
MS4A6A
| 0.0476156 |
APBB1IP
|
CD48
| 0.0580736 |
LCP2
|
PARVG
| 0.0486343 |
APBB1IP
|
LCP2
| 0.0500103 |
LCP2
|
PTPRC
| 0.0510363 |
APBB1IP
|
MYO1G
| 0.0496366 |
MCM5
|
CDT1
| 0.0528149 |
APBB1IP
|
NCKAP1L
| 0.0529768 |
MCM5
|
CHAF1A
| 0.0556453 |
APBB1IP
|
PTPRC
| 0.0576564 |
MCM5
|
DNMT1
| 0.0530079 |
ARHGAP25
|
OR5L2
| 0.0474039 |
MCM5
|
FANCI
| 0.0524277 |
ARHGAP25
|
PARVG
| 0.0495445 |
MCM5
|
LRRFIP2
| 0.0442217 |
ARHGAP25
|
PTAFR
| 0.0442268 |
MCM5
|
PRC1
| 0.0563632 |
ARHGAP25
|
PTPRC
| 0.0448310 |
MCM5
|
RAD54L
| 0.0507543 |
ARHGAP25
|
SYK
| 0.0486975 |
MCM5
|
SPARCL1
| 0.0495283 |
ARHGAP25
|
WDFY4
| 0.0452244 |
MCM5
|
TK1
| 0.0516265 |
MicroRNA | Target gene count | Adjusted P value |
---|---|---|
hsa_GTGCCTT, miR-506 | 22 | 0.0004 |
hsa_TGCTTTG, miR-330 | 14 | 0.0004 |
hsa_GCACTTT, miR-17-5P, miR-20A, miR-106A, miR-106B, miR-20B, miR-519D | 20 | 0.0004 |
hsa_TGCCTTA, miR-124A | 18 | 0.0005 |
hsa_ACTGAAA, miR-30A-3P, miR-30E-3P | 10 | 0.0006 |
hsa_ATACTGT, miR-144 | 10 | 0.0006 |
hsa_AATGTGA, miR-23A, miR-23B | 15 | 0.0006 |
hsa_ACTGTAG, miR-139 | 8 | 0.0006 |
hsa_AGCATTA, miR-155 | 8 | 0.0008 |
hsa_GCATTTG, miR-105 | 9 | 0.0008 |
Analysis of the integrated network
Node | Degree | Node | Degree | Node | Degree | Node | Degree |
---|---|---|---|---|---|---|---|
miR-506 | 22 |
CDH2
| 16 | miR-330 | 14 |
SENP1
| 11 |
FGF2
| 20 |
CXCR4
| 15 |
IMP3
| 13 |
APBB1IP
| 10 |
miR-106A | 20 |
DICER1
| 15 |
SYK
| 13 |
CCL20
| 10 |
miR-106B | 20 |
DLG1
| 15 |
ATP2B2
| 12 | miR-144 | 10 |
miR-17-5P | 20 |
LCP2
| 15 |
DVL3
| 12 | miR-30A-3P | 10 |
miR-20A | 20 |
MCM5
| 15 |
POLR2F
| 12 | miR-30E-3P | 10 |
miR-20B | 20 |
MEF2C
| 15 |
CCL2
| 11 |
RGS7
| 10 |
miR-519D | 20 | miR-23A | 15 |
CSNK2A2
| 11 |
RPS15
| 10 |
SMARCA4
| 19 | miR-23B | 15 |
CXCR6
| 11 |
TLE4
| 10 |
miR-124A | 18 |
EGR2
| 14 |
JAK3
| 11 |
ZNF652
| 10 |
PTPRC
| 17 |
ERBB4
| 14 |
POLR2L
| 11 |