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Erschienen in: Intensive Care Medicine 4/2007

01.04.2007 | Brief Report

A randomized trial of catheter change and short course of antibiotics for asymptomatic bacteriuria in catheterized ICU patients

verfasst von: Marc Leone, Anne-Sophie Perrin, Isabelle Granier, Pierre Visintini, Valery Blasco, François Antonini, Jacques Albanèse, Claude Martin

Erschienen in: Intensive Care Medicine | Ausgabe 4/2007

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Abstract

Objective

To determine the effect on the occurrence of urosepsis of a treatment with a short course of antibiotics and indwelling urethral catheter replacement in clinically asymptomatic intensive care unit (ICU) patients with a positive urine culture occurring at least 48 h after catheterization.

Methods

A prospective randomized clinical trial was conducted in the medico-surgical ICU of a tertiary care centre. Sixty patients hospitalized in the ICU with an indwelling urethral catheter for longer than 48 h developing an asymptomatic positive urine culture were randomized to receive either a 3-day course of antibiotics associated with the replacement of the indwelling urethral catheter 4 h after first antibiotic administration or no antibiotics, no catheter replacement (standard of care).

Results

Three patients in each group developed urosepsis (P = 0.1). There were no significant differences in duration of mechanical ventilation between the study group and the standard of care group (9 [4–20] days vs 5 [2–15] days, P = 0.2), in duration of urinary catheterization (22 [11–40] days vs 18 [14–33] days, P = 0.8), or in length of ICU stay (28 [13–46] vs 19 [15–34], P = 0.6). The recurrence of positive urine culture at days 7 and 15 was not affected by the randomization (P = 0.1). The profile of bacterial resistance was similar in the two groups.

Conclusions

Treating a positive urine culture in an asymptomatic patient with an indwelling urethral catheter does not reduce the occurrence of urosepsis in the medico-surgical ICU.
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Metadaten
Titel
A randomized trial of catheter change and short course of antibiotics for asymptomatic bacteriuria in catheterized ICU patients
verfasst von
Marc Leone
Anne-Sophie Perrin
Isabelle Granier
Pierre Visintini
Valery Blasco
François Antonini
Jacques Albanèse
Claude Martin
Publikationsdatum
01.04.2007
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 4/2007
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0534-1

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