The online version of this article (doi:10.1186/1471-2253-14-93) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
FS and AK have been involved in study conception and design. AGG and FS have been involved in acquisition of data. AGG, AH and FK have been involved in analyzing and interpreting the data. FS did drafting of the manuscript. FS, AK and BB did the critical revision of the manuscript. RL did a critical review of the final manuscript. All authors read and approved the final manuscript.
Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients.
A randomized, double blind, prospective study of patients undergoing open colorectal operations (CR) and open cholecyctectomy (CH) was conducted. Patients were divided into three groups: study, placebo, and control. Visual analogue scale (VAS) scores for seven parameters (thirst, hunger, anxiety, mouth dryness, nausea, weakness and sleep quality) were recorded and compared for two different time periods (up to 24 h postoperatively and from 36 to 48 h postoperatively). The Simplified Acute Physiology Score changes (SAPS)-II between the three groups were also studied.
There were 142 patients American Society of Anesthesiology (ASA) I or II enrolled in the study (CR = 71 and CH = 71). There were no significant differences in postoperative SAPS-II scores or lengths of hospital stay (LOS) between the groups. However, in CR patients, the degree of thirst was partially improved by drinking CRLDs (P = 0.027). In CH patients, on the other hand, feelings of thirst, hunger, mouth dryness, nausea and weakness showed significant improvement (P < 0.05).
Oral administration of carbohydrate-rich liquid drinks (CRLDs) improves the well-being in patients undergoing CH, but the effect is less evident in patients undergoing CR. No significant improvements were seen in clinical status or in length of hospital stay in either group.
ANZCTR.org.au: ACTRN12614000995673 (registered on 16/09/2014).
Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D, Bosanska L, Vokurka M, Svacina S, Haluzik M: Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance. J Clin Endocrinol Metab. 2006, 91: 4620-4627. 10.1210/jc.2006-1044. CrossRefPubMed
Soop M, Nygren J, Myrenfors P, Thorell A, Ljungqvist O: Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance. Am J Physiol Endocrinol Metab. 2001, 280: E576-E583. PubMed
Thorell A, Efendic S, Gutniak M, Häggmark T, Ljungqvist O: Development of postoperative insulin resistance is associated with the magnitude of operation. Eur J Surg. 1993, 159: 593-599. PubMed
Thorell A, Nygren J, Essén P, Gutniak M, Loftenius A, Andersson B, Ljungqvist O: The metabolic response to cholecystectomy: insulin resistance after open compared with laparoscopic operation. Eur J Surg. 1996, 162 (3): 7-91.
Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures. Anesthesiology. 2011, 114: 495-511. 10.1097/ALN.0b013e3181fcbfd9.
Brady M, Kinn S, Stuart P: Preoperative fasting for adults to prevent perioperative complications. Cochrane Database Syst Rev. 2003, 4: CD004423- PubMed
Ljungqvist O, Nygren J, Thorell A, Brodin U, Efendic S: Preoperative nutrition—elective surgery in the fed or the overnight fasted state. Clin Nutr. 2001, 20 (Suppl 1): 167-171. CrossRef
Henriksen MG, Hessov I, Dela F, Hansen HV, Haraldsted V, Rodt SA: Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery. Acta Anaesthesiol Scand. 2003, 47 (2): 191-199. 10.1034/j.1399-6576.2003.00047.x. CrossRefPubMed
Breuer JP, von Dossow V, von Heymann C, Griesbach M, von Schickfus M, Mackh E, Hacker C, Elgeti U, Konertz W, Wernecke KD, Spies CD: Preoperative oral carbohydrate administration to ASA III-IV patients undergoing elective cardiac surgery. Anesth Analg. 2006, 103: 1099-1108. 10.1213/01.ane.0000237415.18715.1d. CrossRefPubMed
de Aguilar-Nascimento JE, Dock-Nascimento DB, Faria MSM, Maria EV, Yonamine F, Silva MR, Adler T: Ingestãopré-operatória de carboidratosdiminui a ocorrência de sintomasgastrointestinaispós-operatóriosempacientessubmetidos à colecistectomia. ABCD Arq Bras Cir Dig. 2007, 20: 77-80.
Hausel J, Nygren J, Almström C: Preoperative oral carbohydrates improves well being after elective colorectal surgery. Clin Nutr. 1999, 18 (suppl. 1): 80-
- A randomized trial of preoperative oral carbohydrates in abdominal surgery
- BioMed Central
Neu im Fachgebiet AINS
Meistgelesene Bücher aus dem Fachgebiet AINS
Mail Icon II