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Erschienen in: Journal of Gastrointestinal Cancer 1/2017

28.01.2016 | Case Report

A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum

verfasst von: Christopher R. Omerza, Andrea Kay Bouman, Patrick P. Bulinski

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 1/2017

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Excerpt

Meckel’s diverticulum (MD) is the most common congenital malformation of the gastrointestinal tract, with an estimated incidence of 1.2 to 4 % [1, 2]. Despite this high prevalence, complications are uncommon, with recent literature suggesting a lifetime complication risk of 4 to 16 %. The most frequent complication is GI hemorrhage associated with ectopic gastric tissue, especially in children. However, obstruction, intussusception, Meckel’s diverticulitis, ulceration, perforation, and neoplasm are also seen [2]. MD is an uncommon location for malignant tumors, with an incidence of 14.4 per 100 million person-years [3]. Gastrointestinal stromal tumors (GISTs) in a MD have an incidence of 1.5 per 100 million person-years [3]. Perforation of a GIST in a MD is an even more rare occurrence, with only 10 cases reported in the literature, and none originating in the USA [413]. Here, we describe a case of a GIST presenting as a perforated Meckel’s diverticulum. …
Literatur
3.
Zurück zum Zitat Thirunavukarasu P, Sathaiah M, Sukumar S, Bartels CJ, Zeh 3rd H, Lee KK, et al. Meckel’s diverticulum-a high-risk region for malignancy in the ileum. Insights from a population-based epidemiological study and implications in surgical management. Ann Surg. 2011;252:223–30. doi:10.1097/SLA.0b013e3181ef488d.CrossRef Thirunavukarasu P, Sathaiah M, Sukumar S, Bartels CJ, Zeh 3rd H, Lee KK, et al. Meckel’s diverticulum-a high-risk region for malignancy in the ileum. Insights from a population-based epidemiological study and implications in surgical management. Ann Surg. 2011;252:223–30. doi:10.​1097/​SLA.​0b013e3181ef488d​.CrossRef
4.
Zurück zum Zitat López-Tomassetti Fernández EM, Hernández JR, Jorge VN. Perforated gastrointestinal stromal tumor in Meckel’s diverticulum treated laparoscopically. Asian J Endosc Surg. 2013;6:126–9. doi:10.1111/ases.12016.CrossRefPubMed López-Tomassetti Fernández EM, Hernández JR, Jorge VN. Perforated gastrointestinal stromal tumor in Meckel’s diverticulum treated laparoscopically. Asian J Endosc Surg. 2013;6:126–9. doi:10.​1111/​ases.​12016.CrossRefPubMed
5.
Zurück zum Zitat Szentpáli K, Palotás A, Wolfárd A, Tiszlavicz L, Balogh A. A gastrointestinal stromal tumour presenting in a perforated Meckel’s diverticulum. Can J Surg. 2004;47:70.PubMedPubMedCentral Szentpáli K, Palotás A, Wolfárd A, Tiszlavicz L, Balogh A. A gastrointestinal stromal tumour presenting in a perforated Meckel’s diverticulum. Can J Surg. 2004;47:70.PubMedPubMedCentral
6.
Zurück zum Zitat Hager M, Maier H, Eberwein M, Klingler P, Kolbitsch C, Tiefenthaler W, et al. Perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor: a case report. J Gastrointest Surg. 2005;9:809–11.CrossRefPubMed Hager M, Maier H, Eberwein M, Klingler P, Kolbitsch C, Tiefenthaler W, et al. Perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor: a case report. J Gastrointest Surg. 2005;9:809–11.CrossRefPubMed
8.
Zurück zum Zitat Caricato M, Mangiameli G, Miccadei F, Bulzomi G, Coppola R. A rare case of complicated Meckel’s diverticulum. Case report and images. Ann Ital Chir. 2010;81:449–51.PubMed Caricato M, Mangiameli G, Miccadei F, Bulzomi G, Coppola R. A rare case of complicated Meckel’s diverticulum. Case report and images. Ann Ital Chir. 2010;81:449–51.PubMed
9.
Zurück zum Zitat Chou YH, Tu CC, Huang CC, Hsieh MS. A clinically-occult gastrointestinal stromal tumor in a Meckel’s diverticulum presenting as hollow organ perforation. Chang Gung Med J. 2011;34:56–61.PubMed Chou YH, Tu CC, Huang CC, Hsieh MS. A clinically-occult gastrointestinal stromal tumor in a Meckel’s diverticulum presenting as hollow organ perforation. Chang Gung Med J. 2011;34:56–61.PubMed
10.
Zurück zum Zitat Sozen S, Ömer T (2012) A rare case of perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor. Arch Iran Med 15:325-327. doi: 012155/AIM.0016. Sozen S, Ömer T (2012) A rare case of perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor. Arch Iran Med 15:325-327. doi: 012155/AIM.0016.
12.
Zurück zum Zitat Woolf R, Blencowe N, Muhammad K, Paterson D, Pye G. A gastrointestinal stromal tumor presenting incidentally with haemorrhage and perforation associated with a Meckel’s diverticulum: a case report. J Med Case Rep. 2009;23:7423. doi:10.4076/1752-1947-3-7423.CrossRef Woolf R, Blencowe N, Muhammad K, Paterson D, Pye G. A gastrointestinal stromal tumor presenting incidentally with haemorrhage and perforation associated with a Meckel’s diverticulum: a case report. J Med Case Rep. 2009;23:7423. doi:10.​4076/​1752-1947-3-7423.CrossRef
13.
14.
Zurück zum Zitat Mulholland MW, Lillemoe KD, Doherty GM, et al. Greenfield’s Surgery: Scientific Principles and Practice. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2011. Mulholland MW, Lillemoe KD, Doherty GM, et al. Greenfield’s Surgery: Scientific Principles and Practice. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2011.
16.
Zurück zum Zitat Bilimoria KY, Bentrem DJ, Wayne JD, Ko CY, Bennett CL, Talamonti MS. Small bowel cancer in the Unites States: changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg. 2009;249:63–71.CrossRefPubMed Bilimoria KY, Bentrem DJ, Wayne JD, Ko CY, Bennett CL, Talamonti MS. Small bowel cancer in the Unites States: changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg. 2009;249:63–71.CrossRefPubMed
17.
Zurück zum Zitat Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1466–78.PubMed Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1466–78.PubMed
18.
Zurück zum Zitat Ma GL, Murphy JD, Martinez ME, Sicklick JK. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomarkers Prev. 2015;24:298–302. doi:10.1158/1055-9965.CrossRefPubMed Ma GL, Murphy JD, Martinez ME, Sicklick JK. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomarkers Prev. 2015;24:298–302. doi:10.​1158/​1055-9965.CrossRefPubMed
19.
Zurück zum Zitat Verweij J, Casali PG, Zalcberg J. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127–34.CrossRefPubMed Verweij J, Casali PG, Zalcberg J. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127–34.CrossRefPubMed
21.
Zurück zum Zitat Dematteo RP, Heinrich MC, El-Rifai WM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol. 2002;33:466–77.CrossRefPubMed Dematteo RP, Heinrich MC, El-Rifai WM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol. 2002;33:466–77.CrossRefPubMed
22.
Zurück zum Zitat Bonvalot S, Eldweny H, Péchoux CL, et al. Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era. Ann Surg Oncol. 2006;13:1596–603.CrossRefPubMed Bonvalot S, Eldweny H, Péchoux CL, et al. Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era. Ann Surg Oncol. 2006;13:1596–603.CrossRefPubMed
23.
Zurück zum Zitat Dematteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51–8.CrossRefPubMedPubMedCentral Dematteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51–8.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Demetri G, Mehren MV, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472–80.CrossRefPubMed Demetri G, Mehren MV, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472–80.CrossRefPubMed
26.
Zurück zum Zitat Antonescu CR, Besmer P, Guo T. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005;11:4182–90.CrossRefPubMed Antonescu CR, Besmer P, Guo T. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005;11:4182–90.CrossRefPubMed
27.
Zurück zum Zitat Demetri GD, Reichardt P, Kang YK, et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381:295–302. doi:10.1016/S0140-6736(12)61857-1.CrossRefPubMed Demetri GD, Reichardt P, Kang YK, et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381:295–302. doi:10.​1016/​S0140-6736(12)61857-1.CrossRefPubMed
Metadaten
Titel
A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum
verfasst von
Christopher R. Omerza
Andrea Kay Bouman
Patrick P. Bulinski
Publikationsdatum
28.01.2016
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Cancer / Ausgabe 1/2017
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-016-9803-y

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