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01.12.2015 | Case report | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Ayako Kumabe, Tsuneaki Kenzaka, Yoshioki Nishimura, Masaki Aikawa, Masaki Mori, Masami Matsumura
Wichtige Hinweise

Competing interests

All authors have no financial interests to disclose and no conflict of interest to declare.

Authors’ contributions

AK: Manuscript redaction. TK: Manuscript redaction, correction and relecture of the manuscript. YN, MA, and MM: Management of the case, manuscript redaction and correction. MM: Manuscript correction, redaction of the comment of the illustrations. All authors read and approved the final manuscript.

Abstract

Background

Anasarca in patients with lymphoma is a rare symptom. We report a patient with DLBCL associated with pituitary gland infiltration that was diagnosed based on significant anasarca.

Case presentation

A 72-year-old woman with a 10-year history of hypertension visited a local hospital presenting with anasarca and 15-kg weight gain in the past 3 months. we clinically diagnosed central hypothyroidism caused by pituitary gland infiltration of diffuse large B-cell lymphoma (DLBCL) (clinical stage IV in the Ann Arbor staging classification). The first course of chemotherapy improved anasarca remarkably and the patient’s body weight returned to what it was 3 months before.

Conclusions

We experienced a patient with remarkable anasarca caused by DLBCL infiltration of the pituitary gland. A pituitary gland lesion with central hypothyroidism should be considered as one of the differential diagnoses of edema. This case was very valuable because we could assess it by following the time course of symptoms (edema and delayed relaxation time of the Achilles tendon reflex), laboratory data, and imaging findings (swelling anterior pituitary lobe).
Literatur
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