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Current Sexual Health Reports
Erschienen in:

06.11.2019 | Female Sexual Dysfunction and Disorders (A Pastuszak and N Thirumavalavan, Section Editors)

A Review of Genome Wide Association Studies for Erectile Dysfunction

verfasst von: Darshan P. Patel, Alexander W. Pastuszak, James M. Hotaling

Erschienen in: Current Sexual Health Reports | Ausgabe 4/2019

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Abstract

Purpose of Review

To review large cohort genome wide association studies for erectile dysfunction.

Recent Findings

Two recent genome wide association studies using the Genetic Epidemiology Research in Adult Health and Aging cohort, UK Biobank, and the Partners HealthCare Biobank have identified an association between unique single nucleotide polymorphisms involved in the regulatory activity of single-minded homolog 1 (SIM1) and risk of erectile dysfunction. SIM1 is involved in the leptin-melanocortin pathway and may contribute to centrally mediated erectile dysfunction.

Summary

Identification of novel loci associated with erectile function from genome wide association studies will help expand the understanding of the breadth of pathways that contribute to erectile dysfunction. This will help accelerate studies of novel therapies for the treatment of erectile dysfunction.
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Metadaten
Titel
A Review of Genome Wide Association Studies for Erectile Dysfunction
verfasst von
Darshan P. Patel
Alexander W. Pastuszak
James M. Hotaling
Publikationsdatum
06.11.2019
Verlag
Springer US
Erschienen in
Current Sexual Health Reports / Ausgabe 4/2019
Print ISSN: 1548-3584
Elektronische ISSN: 1548-3592
DOI
https://doi.org/10.1007/s11930-019-00231-w

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