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World Journal of Pediatrics
Erschienen in: World Journal of Pediatrics 2/2020

25.07.2019 | Review Article

A review of isolated muscular ventricular septal defect

verfasst von: Toshiharu Miyake

Erschienen in: World Journal of Pediatrics | Ausgabe 2/2020

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Abstract

Background

Color Doppler echocardiography greatly facilitates the diagnosis of isolated muscular ventricular septal defect with a small shunt.

Data sources

Original research articles were collected from database, including PubMed and Google scholar. Relevant articles about muscular ventricular septal defect were included.

Results

The frequency of isolated muscular ventricular septal defect is 5.7% in preterm infants and 1.1–5.3% in term infants. Spontaneous closure in muscular ventricular septal defect occurs with higher frequency and earlier than in perimembranous ventricular septal defect. Approximately 80–90% of isolated muscular ventricular septal defect closes spontaneously by 12 months of age. Midventricular muscular ventricular septal defect is spontaneously closed earlier in the short term, but no site difference is found in the long term. The spontaneous closure mechanism is regarded as aposition of the muscle tissue or fibrous tissue formation in the right ventricular side, but in rare cases involves aneurysm formation of the fibrous tissue. Regarding spontaneous closure of isolated muscular ventricular septal defect diagnosed for the fetus, further studies are needed. Chromosomal microarray analysis of fetuses with isolated muscular ventricular septal defect has revealed that it is not a severe risk factor of chromosomal abnormalities.

Conclusions

This paper presents a review of the history of the diagnosis and frequency of ventricular septal defect, with discussion of its natural history from the fetal period to after birth in patients with isolated muscular ventricular septal defect.
Literatur
1.
Egbe A, Uppu S, Lee S, Stroustrup A, Ho D, Srivastava S. Temporal variation of birth prevalence of congenital heart disease in the United States. Congenit Heart Dis. 2015;10:43–50.CrossRefPubMed
2.
Omoto R, Yokote Y, Takamoto S, Kyo S, Ueda K, Asano H, et al. The development of real-time two-dimensional Doppler echocardiography and its clinical significance in acquired valvular diseases. With special reference to the evaluation of valvular regurgitation. Jpn Heart J. 1984;25:325–40.CrossRefPubMed
3.
Miyatake K, Okamoto M, Kinoshita N, Izumi S, Owa M, Takao S, et al. Clinical applications of a new type of real-time two-dimensional Doppler flow imaging system. Am J Cardiol. 1984;54:857–68.CrossRefPubMed
4.
Kapusta L, Hopman JC, Daniels O. The usefulness of cross-sectional Doppler flow imaging in the detection of small ventricular septal defects with left-to-right shunt. Eur Heart J. 1987;8:1002–6.CrossRefPubMed
5.
Trowitzsch E, Braun W, Stute M, Pielemeier W. Diagnosis, therapy, and outcome of ventricular septal defects in the 1st year of life: a two-dimensional colour-Doppler echocardiography study. Eur J Pediatr. 1990;149:758–61.CrossRefPubMed
6.
Ono S, Nakamura S, Hatano T. Muscular ventricular septal defects detected in the early neonatal period. J Jpn Pediatr Soc. 1990;94:1611–5.
7.
Hiraishi S, Agata Y, Nowatari M, Oguchi K, Misawa H, Hirota H, et al. Incidence and natural course of trabecular ventricular septal defect: two-dimensional echocardiography and color Doppler flow imaging study. J Pediatr. 1992;120:409–15.CrossRefPubMed
8.
Mehta AV, Chidambaram B. Ventricular septal defect in the first year of life. Am J Cardiol. 1992;70:364–6.CrossRefPubMed
9.
Waki K, Toyohara K, Ohsaki M, Mitomori T, Baba K, Tanaka M. Incidence of congenital heart disease in early neonates: ventricular septal defect-screening by echocardiography. Acta Cardiol Paed Jpn. 1993;8:596–601.
10.
Ooshima A, Fukushige J, Ueda K. Incidence of structural cardiac disorders in neonates: an evaluation by color Doppler echocardiography and the results of a 1-year follow-up. Cardiology. 1995;86:402–6.CrossRefPubMed
11.
Roguin N, Du ZD, Barak M, Nasser N, Hershkowitz S, Milgram E. High prevalence of muscular ventricular septal defect in neonates. J Am Coll Cardiol. 1995;26:1545–8.CrossRefPubMed
12.
Ramaciotti C, Vetter JM, Bornemeier RA, Chin AJ. Prevalence, relation to spontaneous closure, and association of muscular ventricular septal defects with other cardiac defects. Am J Cardiol. 1995;75:61–5.CrossRefPubMed
13.
Du ZD, Roguin N, Barak M, Bihari SG, Ben-Elisha M. High prevalence of muscular ventricular septal defect in preterm neonates. Am J Cardiol. 1996;78:1183–5.CrossRefPubMed
14.
Du ZD, Roguin N, Wu XJ. Spontaneous closure of muscular ventricular septal defect identified by echocardiography in neonates. Cardiol Young. 1998;8:500–5.CrossRefPubMed
15.
Atalay S, Imamoğlu A, Dilek L, Altuğ N, Tutar E, Gümüş H. Congenital isolated apical ventricular septal defects. Angiology. 1998;49:355–9.CrossRefPubMed
16.
Sands AJ, Casey FA, Craig BG, Dornan JC, Rogers J, Mulholland HC. Incidence and risk factors for ventricular septal defect in “low risk” neonates. Arch Dis Child Fetal Neonatal Ed. 1999;81:F61–3.CrossRefPubMedPubMedCentral
17.
Lin MH, Wang NK, Hung KL, Shen CT. Spontaneous closure of ventricular septal defects in the first year of life. J Formos Med Assoc. 2001;100:539–42.PubMed
18.
Miyake T, Shinohara T, Nakamura Y, Fukuda T, Tasato H, Toyohara K, et al. Spontaneous closure of ventricular septal defects followed up from < 3 months of age. Pediatr Int. 2004;46:135–40.CrossRefPubMed
19.
Kinoshita Y, Sakano T, Otani H, Furue T, Toshiyuki O, Hujiwara S, et al. Natural history of muscular ventricular septal defect. Jpn J Pediatr. 2004;57:1017–20.
20.
Ekici F, Tutar E, Atalay S, Arsan S, Özçelik N. The incidence and follow-up of isolated ventricular septal defect in newborns by echocardiographic screening. Turk J Pediatr. 2008;50:223–7.PubMed
21.
Chang JK, Jien WY, Chen HL, Hsieh KS. Color Doppler echocardiographic study on the incidence and natural history of early-infancy muscular ventricular septal defect. Pediatr Neonatol. 2011;52:256–60.CrossRefPubMed
22.
Zhao QM, Ma XJ, Jia B, Huang GY. Prevalence of congenital heart disease at live birth: an accurate assessment by echocardiographic screening. Acta Paediatr. 2013;102:397–402.CrossRefPubMed
23.
Miyake T, Shinohara T, Inoue T, Marutani S, Takemura T. Spontaneous closure of muscular trabecular ventricular septal defect: comparison of defect positions. Acta Paediatr. 2011;100:e158–62.CrossRefPubMed
24.
Cresti A, Giordano R, Koestenberger M, Spadoni I, Scalese M, Limbruno U, et al. Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up. Congenit Heart Dis. 2018;13:105–12.CrossRefPubMed
25.
Wenink AC, Oppenheimer-Dekker A, Moulaert AJ. Muscular ventricular septal defects: a reappraisal of the anatomy. Am J Cardiol. 1979;43:259–64.CrossRefPubMed
26.
Hagler D, Edwards W, Seward J, Tajik A. Standardized nomenclature of the ventricular septum and ventricular septal defects, with applications for two-dimensional echocardiography. Mayo Clin Proc. 1985;60:741–52.CrossRefPubMed
27.
28.
Graham T. Ventricular septal defect. In: Forrest H, Adams H, Emmanouilides GC, editors. Moss’ heart disease in infants, children, and adolescents. 4th ed. Baltimore: Williams & Wilkins; 1989. p. 189–92.
29.
Jacobs JP, Burke RP, Quintessenza JA, Mavroudis C. Congenital Heart Surgery Nomenclature and Database Project: ventricular septal defect. Ann Thorac Surg. 2000;69:S25–35.CrossRefPubMed
30.
Moe DG, Guntheroth WG. Spontaneous closure of uncomplicated ventricular septal defect. Am J Cardiol. 1987;60:674–8.CrossRefPubMed
31.
Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. Prevalence of congenital heart defects in metropolitan Atlanta, 1998–2005. J Pediatr. 2008;153:807–13.CrossRefPubMedPubMedCentral
32.
Martin GR, Perry LW, Ferencz C. Increased prevalence of ventricular septal defect: epidemic or improved diagnosis. Pediatrics. 1989;83:200–3.PubMed
33.
Meberg A, Otterstad JE, Frøland G, Lindberg H, Sørland SJ. Outcome of congenital heart defects–a population-based study. Acta Paediatr. 2000;89:1344–51.CrossRefPubMed
34.
Schwedler G, Lindinger A, Lange PE, Sax U, Olchvary J, Peters B, et al. Frequency and spectrum of congenital heart defects among live births in Germany: a study of the Competence Network for Congenital Heart Defects. Clin Res Cardiol. 2011;100:1111–7.CrossRefPubMed
35.
Kaburaki Y, Yamaoka K. Incidence and prognosis of congenital heart disease: clinical statistics of 15 years 179 cases. J Kanagawa Med Assoc. 2006;33:6–11.
36.
Haraguchi T, Imanaka H, Takeuchi M. Health checkups for neonates by a practicing pediatrician whose specialty was pediatric cardiology. J Child Health. 2013;72:571–5.
37.
Hu XJ, Ma XJ, Zhao QM, Yan WL, Ge XL, Jia B, et al. Pulse oximetry and auscultation for congenital heart disease detection. Pediatrics. 2017;140:e20171154.CrossRefPubMed
38.
Mitchell SC, Berendes HW, Clark WM Jr. The normal closure of the ventricular septum. Am Heart J. 1967;73:334–8.CrossRefPubMed
39.
Erol O, Şevket O, Keskin S, Yazıcıoğlu HF, Gül A. Natural history of prenatal isolated muscular ventricular septal defects. J Turk Ger Gynecol Assoc. 2014;15:96–9.CrossRefPubMedPubMedCentral
40.
Paladini D, Palmieri S, Lamberti A, Teodoro A, Martinelli P, Nappi C. Characterization and natural history of ventricular septal defects in the fetus. Ultrasound Obstet Gynecol. 2000;16:118–22.CrossRefPubMed
41.
Axt-Fliedner R, Schwarze A, Smrcek J, Germer U, Krapp M, Gembruch U. Isolated ventricular septal defects detected by color Doppler imaging: evolution during fetal and first year of postnatal life. Ultrasound Obstet Gynecol. 2006;27:266–73.CrossRefPubMed
42.
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: single-institution experience. J Ultrasound Med. 2008;27:715–20.CrossRefPubMed
43.
Jin Y, Wang A, Wang Y, Wang Y, Wang W, Hou X. Natural history of prenatal ventricular septal defects and their association with foetal echocardiographic features. Cardiol Young. 2012;22:323–6.CrossRefPubMed
44.
Gómez O, Martinez J, Olivella A, Bennasar M, Crispi F, Masoller N, et al. Isolated ventricular septal defects in the era of advanced fetal echocardiography: risk of chromosomal anomalies and spontaneous closure rate from diagnosis to age of 1 year. Ultrasound Obstet Gynecol. 2014;43:65–71.CrossRefPubMed
45.
Yu L, Xie L, Zhu Q, Dai L, Hua Y, Liu L, et al. Prospective study on the isolated ventricular septal defect in fetus. Zhonghua Er Ke Za Zhi. 2015;53:30–3 (in Chinese).PubMed
46.
Li X, Song GX, Wu LJ, Chen YM, Fan Y, Wu Y, et al. Prediction of spontaneous closure of isolated ventricular septal defects in utero and postnatal life. BMC Pediatrics. 2016;16:207.CrossRefPubMedPubMedCentral
47.
Cho YS, Park SE, Hong SK, Jeong NY, Choi EY. The natural history of fetal diagnosed isolated ventricular septal defect. Prenat Diagn. 2017;37:889–93.CrossRefPubMed
48.
Chau AC, Jones A, Sutherland M, Lilje C, Sernich S, Hagan J, et al. Characteristics of isolated ventricular septal defects less likely to close in utero. J Ultrasound Med. 2018;37:1891–8.CrossRefPubMed
49.
Simmons RL, Moller JH, Edwards JE. Anatomic evidence for spontaneous closure of ventricular septal defect. Circulation. 1966;34:38–45.CrossRefPubMed
50.
Bloomfield DK. The natural history of ventricular septal defect in patients surviving infancy. Circulation. 1964;29:914–55.CrossRefPubMed
51.
Glancy DL, Roberts WC. Complete spontaneous closure of ventricular septal defect: necropsy study of five subjects. Am J Med. 1967;43:846–53.CrossRefPubMed
52.
Suzuki H. Spontaneous closure of ventricular septal defects. Anatomic evidence in six adult patients. Am J Clin Pathol. 1969;52:391-402.
53.
Nir A, Weintraub Z, Oliven A, Kelener J, Lurie M. Anatomic evidence of spontaneous intrauterine closure of a ventricular septal defect. Pediatr Cardiol. 1990;11:208–10.CrossRefPubMed
54.
Kantarci M, Duran C, Bozkurt M, Guven F, Ceviz N, Sagsoz M, et al. Cardiac multidetector computed tomography (MDCT) of spontaneously closed ventricular septal defect. Radiol Med. 2009;114:370–5.CrossRefPubMed
55.
Tandon R, Edwards JE. Aneurysm like formations in relation to membranous ventricular septum. Circulation. 1973;47:1089–97.CrossRefPubMed
56.
Miyake T, Kitayama H, Shinohara T, Ikeoka M, Takemura T, Matsumoto T. Aneurysmal formation induced by membranous tissue in infundibular ventricular septal defect. J Am Soc Echocardiogr. 2005;18:980.CrossRefPubMed
57.
58.
Oztunc F, Demir T, Saltik L, Guzeltas A. Aneurysmal formation in the setting of muscular ventricular septal defects. Cardiol Young. 2007;17:319–21.CrossRefPubMed
59.
Roldan FJ, Vargas-Barrón J, Keirns C, Espinola-Zavaleta N, Rijlaarsdam M, Romero-Cardenas A. Echocardiographic, catheterization, and nuclear medicine findings of an aneurysm of the muscular interventricular septum associated with aneurysm of the interatrial septum. J Am Soc Echocardiogr. 1999;12:879–81.CrossRefPubMed
60.
Dasgupta S, Aly AM. An unusual mechanism of closure of muscular ventricular septal defects. Case Rep Pediatr. 2017;2017:4303298.PubMedPubMedCentral
61.
Khositseth A. Large apical muscular ventricular septal defect: asymptomatic due to anomalous muscle bundles in the right ventricle. Congenit Heart Dis. 2007;2:70–3.CrossRefPubMed
62.
Neumayer U, Stone S, Somerville J. Small ventricular septal defects in adults. Eur Heart J. 1998;19:1573–82.CrossRefPubMed
63.
Gabriel HM, Heger M, Innerhofer P, Zehetgruber M, Mundigler G, Wimmer M, et al. Long-term outcome of patients with ventricular septal defect considered not to require surgical closure during childhood. J Am Coll Cardiol. 2002;39:1066–71.CrossRefPubMed
64.
Kidd L, Driscoll DJ, Gersony WM, Hayes CJ, Keane JF, O’Fallon WM, et al. Second natural history study of congenital heart defects. Results of treatment of patients with ventricular septal defects. Circulation. 1993;87(Suppl 2):I38–51.PubMed
65.
Gersony W, Hayes C, Driscoll D, Keane JF, Kidd L, O’Fallon WM, et al. Bacterial endocarditis in patients with aortic stenosis, pulmonary stenosis, or ventricular septal defect. Circulation. 1993;87(Suppl 2):I121–6.PubMed
66.
Cantinotti M, Assanta N, Murzi B, Lopez L. Controversies in the definition and management of insignificant left-to-right shunts. Heart. 2014;100:200–5.CrossRefPubMed
67.
Smith BG, Qureshi SA. Paediatric follow-up of haemodynamically insignificant congenital cardiac lesions. J Paediatr Child Health. 2012;48:1082–5.CrossRefPubMed
68.
Svirsky R, Brabbing-Goldstein D, Rozovski U, Kapusta L, Reches A, Yaron Y. The genetic and clinical outcome of isolated fetal muscular ventricular septal defect (VSD). J Matern Fetal Neonatal Med. 2019;32:2837–41.CrossRefPubMed
69.
Newman TB. Etiology of ventricular septal defects: an epidemiologic approach. Pediatrics. 1985;76:741–9.PubMed
70.
Nicolae MI, Summers KM, Radford DJ. Familial muscular ventricular septal defects and aneurysms of the muscular interventricular septum. Cardiol Young. 2007;17:523–7.CrossRefPubMed
71.
Clark E. Etiology of congenital cardiovascular malformations: epidemiology and genetics. Moss and Adams’ heart disease in infants, children, and adolescents including the fetus and young adult. 6th ed. Philadelphia: Lippincott Williams and Wilkins; 2001. p. 64–79.
72.
Botto LD, Lynberg MC, Erickson JD. Congenital heart defects, maternal febrile illness, and multivitamin use: a population-based study. Epidemiology. 2001;12:485–90.CrossRefPubMed
73.
Oster ME, Riehle-Colarusso T, Alverson CJ, Correa A. Associations between maternal fever and influenza and congenital heart defects. J Pediatr. 2011;158:990–5.CrossRefPubMed
74.
Shi QY, Zhang JB, Mi YQ, Song Y, Ma J, Zhang YL. Congenital heart defects and maternal fever: systematic review and meta-analysis. J Perinatol. 2014;34:677–82.CrossRefPubMed
Metadaten
Titel
A review of isolated muscular ventricular septal defect
verfasst von
Toshiharu Miyake
Publikationsdatum
25.07.2019
Verlag
Springer Singapore
Erschienen in
World Journal of Pediatrics / Ausgabe 2/2020
Print ISSN: 1708-8569
Elektronische ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-019-00289-5

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