Introduction
Different Lasers Available with Micropulse Mode
810-nm Diode Laser
577-nm Yellow Laser
Applications for Subthreshold Micropulse Lasers
Authors | Year | Eyes | Disease duration | Laser type and parameters | Study design |
---|---|---|---|---|---|
Ricci et al. [27] | 2004 | 1 eye | Chronic, ≥6 months | Iris Medical Oculight SLx 810 nm, Ø not shown, 10% DC, 0.5 s, power: 500 mW | Case report, SML after ICG injection |
Ricci et al. [28] | 2008 | 7 eyes | Chronic, ≥6 months | Iris Medical Oculight SLx 810 nm, Ø 112.5 µm, 10% DC, 0.5 s, power: 500 mW | Prospective, interventional, non-comparative case series, SML after ICG injection |
Chen et al. [29] | 2008 | 26 eyes Group 1: Source leakage without RPE atrophy, n = 6 Group 2: Source leakage with RPE atrophy, n = 9 Group 3: Diffuse RPE decompensation with indeterminate source leakage, n = 11 | Chronic, >4 months | Iris Medical Oculight SLx 810 nm, Ø 125 µm, 15% DC, 0.2 s, power: titration | Prospective, non-comparative, interventional case series |
Lanzetta et al. [30] | 2008 | 24 eyes | Chronic, >3 months | Iris Medical Oculight SLx 810 nm, Ø 200 µm, 15% DC, 0.2 s, power: 1000–2000 mW, mean 1350 mW | Prospective, interventional, non-comparative case series |
Gupta et al. [31] | 2009 | 5 eyes | Chronic, ≥4 weeks | Iris Medical Oculight SLx 810 nm, Ø 125 µm, 15% DC, 0.2 s, power: titration | Retrospective, non-comparative, case series |
Koss et al. [32] | 2011 | 52 eyes SML: n = 16 BCZ: n = 10 Observation: n = 26 | Chronic, >3 months | Iris Medical Oculight SLx 810 nm, Ø 125 µm, 15% DC, 0.2 s, power: titration | Prospective, comparative, nonrandomized interventional case series |
Roisman et al. [33] | 2013 | 15 eyes SML: n = 10 SHAM: n = 5 | Chronic, >6 months | Opto FastPulse 810 nm, Ø 125 µm, 15% DC, 0.3 s, power: 1.2× threshold | Prospective, randomized, double-blind, sham-controlled pilot trial, cross over after 3 months |
Malik et al. [34] | 2015 | 11 eyes | Chronic, >3 months | Iris Medical Oculight SLx 810 nm, Ø not shown, 5% DC, 0.2–0.3 s, power: 750–1000 mW | Retrospective, interventional, non-comparative case series |
Kretz et al. [35] | 2015 | 62 eyes SML: n = 20 HdPDT: n = 24 Observation: n = 18 | Chronic, >3 months | Iris Medical Oculight SLx 810 nm, Ø 75–125 µm, 15% DC, 0.3 s, power: average 1500 mW | Prospective, randomized, interventional, comparative trial |
Elhamid [36] | 2015 | 15 eyes | Chronic, >3 months | Iridex IQ577 577 nm, Ø 200 µm, 10% DC, 0.2 s, power: titration | Prospective, interventional, non-comparative clinical study |
Scholz et al. [37] | 2015 | 38 eyes | Chronic, >6 weeks | Quantel Medical Supra Scan 577 nm, Ø 160 µm, 5% DC, 0.2 s, power: 50% of threshold | Retrospective, non-comparative case series |
Kim et al. [38] | 2015 | 10 eyes | Chronic, >6 months | Quantel Medical Supra Scan 577 nm, Ø 100 µm, 15% DC, 0.2 s, power: 50% of threshold | Retrospective, non-comparative case series |
Gawęcki [39] | 2015 | 1 eye | Chronic, (disease duration not defined) | Model not mentioned 577 nm, Ø 160 µm, 5% DC, 0.2 s, power: 550 mW | Retrospective case report |
Yadav et al. [40] | 2015 | 15 eyes | Chronic, >3 months | Quantel Medical Supra Scan 577 nm, Ø 100 µm, 10% DC, 0.2 s, power: 50% of threshold | Retrospective, non-comparative case series |
Breukink et al. [41] | 2016 | 59 eyes (All eyes received HdPDT, 10 eyes with persistent SRF after up to 2 HdPDT sessions received SML) | Chronic, (disease duration not defined) | Iris Medical Oculight SLx 810 nm, Ø 125 µm, 5% DC, 0.2 s, power: ≤1800 mW | Prospective, interventional non-comparative, case series |
Özmert et al. [42] | 2016 | 33 eyes SML: n = 15 HfPDT: n = 18 | Chronic, >6 months | Quantel Medical Supra Scan 577 nm, Ø 160 µm, 5% DC, 0.2 s, power: titration | Retrospective, comparative case series |
Ambiya et al. [43] | 2016 | 10 eyes | ≥3 months without signs of RPE atrophy or diffuse leakage | Navilas 577 nm, Ø 100 µm, 5% DC, 0.1 s, power: 30% of threshold | Prospective, interventional noncomparative, case series |
Scholz et al. [44] | 2016 | 100 eyes SML: n = 42 HdPDT: n = 58 | Chronic, ≥6 weeks | Quantel Medical Supra Scan 577 nm, Ø 160 µm, 5% DC, 0.2 s, power: 50% of threshold | Retrospective, comparative, interventional case series |
Authors | FU | Treatment response | Central retinal thickness | Best corrected visual acuity | Safety | Laser sessions |
---|---|---|---|---|---|---|
Ricci et al. [27] | 8 weeks | 1 week: SRF was reduced (1/1) | Not shown | BL: 0.3 logMAR 1 week: 0.0 logMAR 8 weeks: −0.1 logMAR | No signs of laser treatment were visible on FA | 1 |
8 weeks: Complete resolution (1/1) | ||||||
Ricci et al. [28] | Minimum 12 months | Response*: 2 weeks: 7/7 (100%) 8 weeks: 7/7 (100%) Complete*: 5/7 (71%) *12 months: no recurrence in patients with complete resolution of SRF. No worsening of SRF in patients with incomplete recovery | Not shown | 2 weeks: all patients showed improvement 12 months: no worsening of the BCVA Change: +0.19 logMAR Significant increase of BCVA after 12 months (p < 0.05) | No laser lesions were visible via funduscopic examination and on FA | 1 |
Chen et al. [29] | Minimum 6 months (9.5 ± 2.6 months) | FFU response: Group 1: 6/6 (100%) Group 2: 8/9 (89%) Group 3: 5/11(46%) All eyes: 19/26 (73%) | Group 1: BL: 339 ± 67 µm FFU: 136 ± 26 µm Group 2: BL: 342 ± 84 µm FFU: 139 ± 34 µm Group 3: BL: 340 ± 121 µm FFU: 192 ± 103 µm Significant CRT decrease in all patients (p < 0.001) | Group 1: BL: 0.18 ± 0.08 logMAR FFU: 0.00 ± 0.00 logMAR Group 2: BL: 0.38 ± 0.19 logMAR FFU: 0.07 ± 0.06 logMAR Group 3: BL: 0.41 ± 0.28 logMAR FFU: 0.24 ± 0.22 logMAR Significant BCVA increase in all patients (p = 0.01) | No patients developed laser-related scotoma | 1–3 |
FFU complete: Group 1: 6/6 (100%) Group 2: 8/9 (89%) Group 3: 5/11 (46%) All eyes: 19/26 (73%) | ||||||
Lanzetta et al. [30] | 3–36 months (mean 14 months) | Response: 1 month: 16/24 (67%) FFU: 18/24 (75%) | BL: 328 µm (range 162–720 µm) 1 month: 197 µm (range 93–403 µm) FFU: 168 µm (range 107–340 µm) Significant CRT decrease at 1 month (p = 0.0003) and FFU (p < 0.0001) | BL: 20/32 Snellen 1 month: 20/25 Snellen FFU: 20/25 Snellen No significant increase in BCVA at 1 month (p = 0.64) or FFU (p = 0.062) | −5/24 eyes showed RPE changes at the site of SML spots No complications | 1–5 |
Complete: 1 month: 9/24 (38%) FFU: 17/24 (71%) | ||||||
Gupta et al. [31] | Minimum 6 months | FU response: 5/5 (100%) | Not shown | Improvement in BCVA in all patients | No complications mentioned | 1–2 |
FU complete: 4/5 (80%) | ||||||
Koss et al. [32] | 10 months | FU response: not shown FU complete: not shown Leakage activity in FA 10 months: SML: 2/16 (12.5%) BCZ: 6/10 (60%) Observation: 24/26 (92%) SML leads to significantly more leakage activity reduction than BCT (p = 0.0239) and observation (p = 0.0054) | SML: BL: 419 ± 59 µm 6 weeks: 387 ± 94 µm 6 months: 329 ± 69 µm 10 months: 325 ± 93 µm BCZ: BL: 393 ± 84 µm 6 weeks: 355 ± 114 µm 6 months: 334 ± 59 µm 10 months: 355 ± 73 µm Observation: BL: 388 ± 59 µm 6 weeks: 396 ± 57 µm 6 months: 388 ± 63 µm 10 months: 415 ± 53 µm Significant decrease in CRT at (p = 0.0098) but not after BCZ or observation | SML: BL: 45.4 ± 7.2 ETDRS 6 weeks: 47.8 ± 6.8 ETDRS 6 months: 50.5 ± 7.3 ETDRS 10 months: 51.6 ± 7.0 ETDRS BCZ: BL: 44.1 ± 10.8 ETDRS 6 weeks: 41.9 ± 11.3 ETDRS 6 months: 42.4 ± 13.6 ETDRS 10 months: 43.5 ± 14.5 ETDRS Observation: BL: 46.4 ± 6.1 ETDRS 6 weeks: 46.3 ± 6.9 ETDRS 6 months: 44.9 ± 5.1 ETDRS 10 months: 44.3 ± 5.2 ETDRS SML better than BCZ (p = 0.000047) and observation (p = 0.0054) at 10 months | No ocular adverse events, i.e., intraocular inflammation, bleeding, or IOP rise, were observed | 1–3 |
Roisman et al. [33] | Minimum 6 months | Not shown | SML: BL: 420 ± 112 µm 1 month: 307 ± 55 µm 3 months: 265 ± 98 µm SHAM: BL: 350 ± 61 µm 1 month: 351 ± 94 µm 3 months: 290 ± 78 µm No significant decrease in CRT at 3 months after SML (p = 0.091) or SHAM treatment (p = 0.225) | SML: BL: 35.4 ± 11.6 ETDRS 1 month: 44.4 ± 8.1 ETDRS 3 months: 47.9 ± 8.0 ETDRS SHAM BL: 26.6 ± 6.8 ETDRS 1 month: 26.8 ± 7.6 ETDRS 3 months: 25.6 ± 8.9 ETDRS Significant BCVA increase at 3 months after SML (p = 0.008) but not after SHAM treatment (p = 0.498) | No laser scars observed at funduscopic examination or on FA | 1–2 |
Malik et al. [34] | Minimum 2 months (2–12 months) | FU response: 8/11 (72%) FU complete: not shown | BL: 414 ± 137 µm FFU: 316 ± 97 µm Significant CRT decrease after SML (p = 0.0046) | BL: 39.2 ± 15.1 ETDRS FFU: 45.5 ± 12 ETDRS | No evidence of RPE damage in FAF or in FA | 1–2 |
Kretz et al. [35] | 4 months | 4-month response (reduction of leakage activity): SML: 12/20 (60%) HdPDT: 16/24 (67%) Observation: 7/18 (38%) Significant reduction of leakage activity in both treatment groups compared to the control group | Change BL/4 months: SML: −69.7 µm HdPDT: −109.8 µm Observation: −89 µm | Change BL/4 months: SML: +6.7 ETDRS HdPDT: +8.5 ETDRS Observation: +1.5 ETDRS | No evidence of secondary RPE damage in FAF after both treatments | 1–3 |
Elhamid [36] | 6 months | Response: 3 months: 15/15 (100%) | BL: 390 ± 46 µm 6 months: 264 ± 24 µm Significant CRT decrease after SML (p < 0.05) | BL: 0.67 ± 0.10 Snellen 6 months: 0.85 ± 0.10 Snellen Significant BCVA increase after SML (p < 0.05) | No sign of laser-induced lesions | 1–2 |
Complete: 3 months: 11/15 (73%) 6 months: 13/15 (86%) | ||||||
Scholz et al. [37] | Minimum 6 weeks (mean 5 ± 3 months) | Response: 6 weeks: 24/38 (63%) 3 months: 20/23 (87%) 6 months: 11/14 (79%) FFU: 28/38 (74%) | BL: 402 ± 139 µm 6 weeks: 309 ± 86 µm FFU: 287 ± 75 µm Significant CRT decrease after SML (p < 0.001) | BL: 0.36 ± 0.24 logMAR 6 weeks: 0.33 ± 0.24 logMAR FFU: 0.30 ± 0.25 logMAR Significant BCVA increase after SML (p = 0.039) | No laser burns were detected with any imaging modality | 1–3 |
Complete: 6 weeks: 5/38 (13%) 3 months: 7/23 (30%) 6 months: 2/14 (14%) FFU: 9/38 (24%) | ||||||
Kim et al. [38] | Minimum 3 months | There were 2 patients who had recurrent CSC. One at 6 months, one at 10 months. One patient had persistent SRF for 3 months despite total of 4 laser sessions | BL: 349 ± 53 μm 3 months: 251 ± 29 μm FFU: 261 ± 38 μm Significant CRT decrease at 3 months (p = 0.009) and FFU (p = 0.009) | BL: 0.21 ± 0.21 logMAR 3 months: 0.06 ± 0.09 logMAR FFU: 0.04 ± 0.06 logMAR Significant BCVA increase at 3 months (p = 0.020) and FFU (p = 0.012) | No laser scar was detected in color fundus photographs, SDOCT, or near-infrared images | 1–5 |
Gawęcki [39] | Not specified | Response: 0/1 | After 1st treatment: no change After 2nd treatment: “significant amount of SRF present in the macular area” | BL: 0.63 decimal FU 1st*: no change FU 2nd*: 0.32 decimal treatment* | FAF showed hyperfluorescent punctate areas referring to multispot SML pattern | 2 |
Complete: 0/1 | ||||||
Yadav et al. [40] | Minimum 4 weeks (4–19 weeks) | FU: Response: 15/15 (100%) Complete: 6/15 (40%) | CRT not shown SRF (high): BL: 232 µm FU: 49 µm Significant decrease in SRF (p < 0.001) | Change: 1 line BL: 20/40 Snellen FU: 20/30 Snellen Significant BCVA increase (p = 0.015) | No evidence of RPE or retinal damage on SDOCT, FA, or on FAF | 1 |
Breukink et al. [41] | 8–118 weeks | After mean 8.7 weeks, (range: 4–18 weeks) Complete after: 1st HdPDT: 37/59 (63%) 2nd HdPDT: 7/19 (37%) 1st SML: 1/10 (10%) | Not shown | BL (all): 0.28 logMAR FFU (all): 0.16 logMAR No difference in eyes after HdPDT or SML | 1–2 HdPDT 1 SML | |
Özmert et al. [42] | Minimum 12 months | SML: Response: 13/15 (87%) Complete: 12/15 (80%) HfPDT: Response: 14/18 (78%) Complete: 13/18 (72%) | SML: BL: 287.3 ± 126 µm 12 months: 138.0 ± 40 µm HfPDT: BL: 242.8 ± 80 µm 12 months: 156.9 ± 60 µm Significant CRT decrease after SML (p = 0.003), but not after hfPDT (p = 0.098) | SML: BL: 67.3 ± 14.2 ETDRS 12 months: 71.5 ± 21.4 ETDRS HfPDT: BL: 60.7 ± 16.3 ETDRS 12 months: 64.4 ± 24.9 ETDRS No significant increase in both groups SML: p = 0.285, hfPDT: p = 0.440 | No visible retinal scarring | 1–2 |
Ambiya et al. [43] | 6 months | Response: 1 month: 10/10 Complete: 1 month: 4/10 (40%) 3 month: 6/10 (60%) 6 months: 6/10 (60%) | BL: 298 ± 129 µm 1 month: 200 ± 72 µm 3 months: 179 ± 53 µm 6 months: 215 ± 90 µm Significant CRT decrease at 6 months (p = 0.03) | BL: 73.3 ± 16.1 ETDRS 1 month: 73.1 ± 16.3 ETDRS 3 months: 75.8 ± 14.0 ETDRS 6 month: 76.9 ± 13.0 ETDRS No significant increase in BCVA (p = 0.59) | No evidence of laser spots via funduscopic examination, on SDOCT, and on FAF No complications | 1–2 |
Scholz et al. [44] | 6 weeks | SML 6 weeks: Response: 33/42 (79%) Complete: 15/42 (36%) HdPDT 6 weeks: Response: 34/58 (59%) Complete: 12/58 (21%) SML showed higher treatment response than HdPDT (p = 0.036) | SML: BL: 445 ± 153 µm 6 weeks: 297 ± 95 µm HdPDT: BL: 398 ± 88 µm 6 weeks: 322 ± 93 µm Significant decrease in both groups (SML: p < 0.001, hdPDT: p < 0.001) CRT decrease better after SML (p = 0.041) | SML: BL: 0.39 ± 0.24 logMAR 6 weeks: 0.31 ± 0.27 logMAR HdPDT: BL: 0.35 ± 0.24 logMAR 6 weeks: 0.31 ± 0.24 logMAR Significant BCVA increase after SML (p = 0.003), but not after HdPDT (p = 0.07) | No laser spots detectable by funduscopic examination or on FA | 1 |
Authors | Year | Eyes | Inclusion criteria | Laser type and parameters | Study design |
---|---|---|---|---|---|
Fazel et al. [45] | 2016 | 68 eyes SML: n = 34 CL: n = 34 | DME* CRT <450 µm Without PDR Without previous IVT or any retinal laser | Quantel Medical 810 nm, Ø 50–100 µm, 0.1 s, power: adjusted Quantel Medical 810 nm, Ø 75–125 µm, 15% DC, 0.0003 s, power: 2× threshold | Prospective, single-blind, randomized clinical trial |
Inagaki et al. [46] | 2015 | 53 eyes 810 nm: n = 24 577 nm: n = 29 | DME*, type II with or without NPDR/PDR No IVT or laser within the last 3 months Patients with isolated local FA dye were excluded | Iris Medical IQ577 577 nm, Ø 200 µm 15% DC, 0.2 s, power: 2× threshold, (mean 204 mW) Iris Medical OcuLight SLX, 810 nm, Ø 200 µm 15% DC, 0.2 s, power: 2× threshold, (mean 955 mW) | Prospective, non-randomized, interventional case series Additional micro-aneurysm closure in both groups at BL |
Vujosevic et al. [47] | 2015 | 53 eyes 810 nm: n = 27 577 nm: n = 26 | DME* <400 µm, type I/II diabetes No macular therapy, IVT, laser, ppV previously | Iris Medical IQ577 577 nm, Ø 100 µm, 5% DC, 0.2 s, power: 250 mW, HD treatment Iris Medical OcuLight SLX, 810 nm, Ø 125 µm, 5% DC, 0.2 s, power: 750 mW, HD treatment | Prospective, masked, randomized, comparative pilot study |
Othman et al. [48] | 2014 | 220 eyes Group 1 Primary treatment (n = 187) Group 2 Secondary treatment (n = 33) | DME* without PDR and foveal ischemia Group 1 without prior treatment, BCVA at least 20/80 Group 2 with prior CL, BCVA at least 20/200 | Iris Medical OcuLight SLX 810 nm, Ø 75–125 µm, 15% DC, 0.3 s, power: 650–1000 mW confluent | Prospective, single-center, nonrandomized, interventional case series |
Venkatesh et al. [49] | 2011 | 46 eyes SML: n = 23 CL: n = 23 | DME* without PDR No prior medical or laser treatment within the last 6 months | Iris Medical OcuLight SLX, 810 nm, Ø 125 µm, 10% DC, 2 s, power: 80–130 mW Zeiss Visulas Nd:YAG LC 532 nm, Ø 50–100 µm, 0.1 s, power: 90–180 mW | Prospective, randomized interventional study |
Lavinsky et al. [50] | 2011 | 123 eyes ND-SLM: n = 39 HD-SLM: n = 42 CL: n = 42 | DME* with CRT ≥250 µm No prior macular laser or IVT for DME No panretinal laser within last 4 months | Opto FastPulse 810 nm, Ø 125 µm, 15% DC, 0.3 s 0.3 s, power: 1.2× threshold ND-SML: 2 invisible burn widths apart HD-SML: Confluent invisible burn Iridex, Nd:YAG LC 532 nm, Ø 75 µm, 0.05–0.1 s, power: titration mETDRS grid | Prospective, randomized, controlled, double-masked clinical trial |
Ohkoshi and Yamaguchi [51] | 2010 | 43 eyes | DME* with CRT ≤600 µm without PDR Type II Patients with isolated local FA dye were excluded No prior medical or laser treatment within last 6 months | Iris Medical OcuLight SLX 810 nm, Ø 200 µm, 15% DC, 0.2–0.3 s, power: 520–100 mW confluent | Prospective, nonrandomized interventional study |
Nakamura et al. [52] | 2010 | 28 eyes | DME* No prior laser or surgical therapy within last 6 months | Iris Medical OcuLight SLX 810 nm, Ø 200 µm, 15% DC, 0.2 s, power: titrated, grid pattern was used | Prospective |
Vujosevic et al. [53] | 2010 | 62 eyes SML: n = 32 CL: n = 30 | DME*, type II No prior medical/laser/surgical treatment within last 6 months | Coherent Novus Omni laser, 514 nm, Ø 100 µm, 0.1 s, power: 80–100mW mETDRS grid CL Iris Medical OcuLight SLX 810 nm, Ø 125 µm 5% DC, 0.2 s, power: 750mW | Prospective, randomized clinical trial (retreatment after 3 months if: CMT ≥250 µm or CMT reduction ≤50% or BCVA decrease >5 ETDRS letters) |
Figueira et al. [54] | 2009 | 84 eyes SML: n = 44 CL: n = 40 | Both eyes DME*, type II, <80 years without PDR No prior laser treatment | Iridex Oculite GLx argon green 514 nm, Ø 100–200 µm 0.1 s, power: titration Iris Medical OcuLight SLX 810 nm, Ø 125 µm 15% DC, 0.3 s, power: titration | Prospective, randomized, controlled, double-masked trial |
Laursen et al. [55] | 2004 | 23 eyes SML: n = 12 (Diffuse, n = 6; focal: n = 6) CL n = 11 (Diffuse, n = 6; focal, n = 5) | DME* without PDR Without prior LC Without retinal surgery | Iris Medical OcuLight SLX 810 nm, Ø 125 µm 5% DC, 0.1 s, power: titration Novus 200 argon green 514 nm, Ø 100 µm, 0.1 s, power: titration | Prospective, randomized |
Authors | FU (months) | Central retinal thickness | Best corrected visual acuity | Safety | Additional treatments |
---|---|---|---|---|---|
Fazel et al. [45] | 4 | 810 nm SML: BL: 373 ± 56 µm 4 months: 344 ± 60 µm 810 nm CL: BL: 355 ± 53 µm 4 months: 350 ± 54 µm SML superior to CL (p = 0.001; 4 months) | 810 nm SML: BL: 0.59 ± 0.3 logMAR 4 months: 0.52 ± 0.3 logMAR 810 nm CL: BL: 0.58 ± 0.3 logMAR 4 months: 0.60 ± 0.3 logMAR SML superior to CL (p = 0.015; 4 months) | No laser scars after SML Laser scars after CL | Not mentioned |
Inagaki et al. [46] | 12 | 810 nm: BL: 488 ± 176 µm 3 month: 404.5 µm 6 months: 394.4 µm 12 months: 361.8 µm 577 nm: BL: 417 ± 113 µm 3 months: 345.8 µm 6 months: 340.6 µm 12 months: 335.2 µm No significant difference between groups after 12 months | 810 nm: BL: 0.59 ± 0.41 logMAR 3 months: 0.57 logMAR 6 months: 0.53 logMAR 12 months: 0.54 logMAR 577 nm: BL: 0.31 ± 0.31 logMAR 3 months: 0.32 logMAR 6 months: 0.32 logMAR 12 months: 0.28 logMAR BCVA stable in both groups, intergroup differences were not evaluated | No laser scars in either group | 810 nm: 12.5% Re-SML, 4.2% IVT (bevacizumab) 5–577 nm: 3.4% Re-SML |
Vujosevic et al. [47] | 6 | 810 nm: BL: 340 ± 36 µm 6 months: 335 ± 55 µm 577 nm: BL: 358 ± 46 µm 6 months: 340 ± 56 µm Significant decrease for 577 nm group at 6 months (p = 0.009) and not for 810 nm (p = 0.45) No significant difference between the groups at 6 months | 810 nm: BL: 78.6 ± 7.5 ETDRS 3 months: 79.3 ± 6.8 ETDRS 6 months: 77.3 ± 8.2 ETDRS 577 nm: BL: 79.7 ± 6.1 ETDRS 3 months: 79.4 ± 7.6 ETDRS 6 months: 78.7 ± 7.4 ETDRS No significant difference of BCVA between groups at 3 months (p = 0.3) and at 6 months (p = 0.62) | No laser scars or visible secondary effects of laser spots in either group | 810 nm: 85.2% Re-SML 5–577 nm: 88.5% Re-SML |
Othman et al. [48] | 12 | 810 nm: Primary treatment (1) BL: 353 ± 80 µm 4 months: 257 ± 51 µm 12 months: 215 ± 27 µm 810 nm: Secondary treatment (2) BL: 429 ± 69 µm 4 months: 356 ± 64 µm 12 months: 263 ± 59 µm In both groups, CRT decrease was significant at 4 and 12 months (p < 0.05) | 810 nm: primary treatment (1) BL: 0.21 logMAR 4 months: 0.15 logMAR 12 months: 0.18 logMAR 810 nm: secondary treatment (2) BL: 0.50 logMAR 4 months: 0.44 logMAR 12 months: 0.46 logMAR In group 1, BCVA improved at 4 months (p = 0.017) and was stable at 12 months for 85% of the eyes In group 2, no significant BCVA change was observed | Laser marks seen as pigmentary changes were noted 3.3% via funduscopic examination and 5.7% via FA | Group 1: 23% Re-SML (median 2 × SML) 11.7% IVT (triamcinolone) 3.2% ppV Group 2: 33% IVT (triamcinolone) |
Venkatesh et al. [49] | 6 | 810 nm SML: BL: 299 ± 50 µm 3 months: 287 ± 53 µm 6 months: 275 ± 63 µm 532 nm YAG CL: BL: 313 ± 47 µm 3 months: 296 ± 34 µm 6 months: 287 ± 33 µm No difference between SML and CL (p = 0.064) | 810 nm SML: BL: 0.41 ± 0.3 logMAR 3 months: 0.41 ± 0.3 logMAR 6 months: 0.43 ± 0.3 logMAR 532 nm YAG CL: BL: 0.33 ± 0.2 logMAR 3 months: 0.36 ± 0.2 logMAR 6 months: 0.41 ± 0.3 logMAR No difference between SML and CL (p = 0.77) for BCVA. Better preservation of retinal sensitivity in SML group | In mfERG: 810 nm SML: 4/23 eyes with focal void regions 532 nm YAG-CL: 18/23 eyes with focal void regions | Not mentioned |
Lavinsky et al. [50] | 12 | 810 nm ND-SML: BL: 379 (279–619) µm 3 months: 332 (223–610) µm 6 months: 316 (215–627) µm 12 months: 311 (207–599) µm 810 nm HD-SML: BL: 371 (297–879) µm 3 months: 301 (203–698)µm 6 months: 291 (201–577) µm 12 months: 226 (187–513) µm 532 nm YAG mETDRS CL: BL: 370 (269-710) µm 3 months: 306 (209–512) µm 6 months: 290 (208–501) µm 12 months: 249 (199–475) µm HD-SML, CL were superior to ND-SLM group (p < 0.001) No difference between HD-SDM and CL groups (p = 0.75) | 810 nm ND-SML: BL: 0.70 (0.4–1.3) logMAR 3 months: 0.80 (0.4–1.3) logMAR 6 months: 0.80 (0.4–1.3) logMAR 12 months: 0.80 (0.3–1.3) logMAR 810 nm HD-SML: BL: 0.90 (0.3–1.3) logMAR 3 months: 0.70 (0.2–1.3) logMAR 6 months: 0.60 (0.2–1.3 logMAR 12 months: 0.52 (0.2–1.3) logMAR 532 nm YAG mETDRS CL: BL: 0.80 (0.3–1.3) logMAR 3 months: 0.75 (0.3–1.3) logMAR 6 months: 0.70 (0.2–1.3) logMAR 12 months: 0.65 (0.3–1.3) logMAR HD-SML with significant BCVA increase 12 months (p = 0.009), ND-SML and CL group: No improvement | SML: No laser scars or visible laser burns after SML, although some very light laser-induced lesions could be identified CL: laser scars after CL | 810 nm ND-SML: 21% re-SML (once) 77% Re-SML (twice) 810 nm HD-SML: 38% Re-SML (once) 13% Re-SML (twice) 532 nm CL: 32% Re-CL (once) 24% Re-CL (twice) |
Ohkoshi and Yamaguchi [51] | 12 | 810 nm SML: BL: 342 ± 119 µm 3 months: 301 ± 124 µm 6 months: 292 ± 122 µm 12 months: 290 ± 123 µm CRT reduction was significant at 3 months (p = 0.05) and stable afterwards | 810 nm SML: BL: 0.12 ± 0.2 logMAR 3 months: 0.12 ± 0.2 logMAR 6 months/12 months: N/A Stable BCVA until 12 months | No laser scars, no evidence of laser treatment After 1 year, one patient showed pigmentary changes | 19% re-SML (once) 7% 1× grid CL 2% 1× CL of microaneurysm 2% IVT 4% ppV |
Nakamura et al. [52] | 3 | 810 nm SML, CFT changes: BL: 481 ± 110 µm 3 months: 388 ± 127 µm Significant CFT reduction at 3 months (p = 0.004) | 810 nm SML BL: 0.47 ± 0.2 logMAR 3 months: 0.40 ± 0.2 logMAR Significant BCVA improve at 3 months (p = 0.03) | No laser scars, no evidence of laser treatment | Not mentioned |
Vujosevic et al. [53] | 12 | 810 nm SML: BL: 358 ± 94 µm 3 months: 341 ± 114 µm 6 months: 346 ± 113 µm 12 months: 312 ± 76 µm 514 nm argon CL: BL: 378 ± 95 µm 3 months: 338 ± 72 µm 6 months: 327 ± 77 µm 12 months: 310 ± 87 µm No significant difference between CL and SML | 810 nm SML: BL: 0.21 ± 0.30 logMAR 3 months: 0.23 ± 0.29 logMAR 6 months: 0.24 ± 0.32 logMAR 12 months: 0.24 ± 0.25 logMAR 514 nm argon CL: BL: 0.29 ± 0.30 logMAR 3 months: 0.32 ± 0.33 logMAR 6 months: 0.29 ± 0.27 logMAR 12 months: 0.30 ± 0.30 logMAR No significant difference between CL and SML | SML: No signs of laser treatment via funduscopic examination and on FA CL: laser scars after CL | Number of treatments: SML: 2.03 ± 0.75 CL: 2.10 ± 1.0 |
Figueira et al. [54] | 12 | 810 nm SML: BL: 249 ± 59 µm 12 months: 291 ± 104 µm 514 nm Argon CL: BL: 255 ± 62 µm 12 months: 284 ± 105 µm No significant differences between CL and SML (p = 0.81) | 810 nm SML: BL: 78.4 ± 8.1 ETDRS 12 months: 71.8 ETDRS 514 nm argon CL: BL: 78.0 ± 7.8 ETDRS 12 months: 70.70 ETDRS No significant differences between CL and SML (p = 0.88) | SML: 13.9% of the treated eyes showed laser scars CL: 59% of the treated eyes showed laser scars | Not mentioned |
Laursen et al. [55] | 5–8 | Focal LC/diffuse LC Central retinal thickness 810 nm SML focal LC (n = 6): BL: 275 µm 3 months: 250 µm 6 months: 256 µm 810 nm SML diffuse LC: (n = 6) BL: 293 µm 3 months: 318 µm 6 months: 341 µm 514 nm argon focal LC (n = 5) BL: 325 µm 3 months: 338 µm 6 months: 330 µm 514 nm argon diffuse LC (n = 6): BL: 272 µm 3 months: 308 µm 6 months: 90 µm In all patients with focal edema CRT decrease significant (p = 0.02) | BL BCVA cannot be extracted! 810 nm SML focal LC (n = 6) 3 months: +2.8 ETDRS 6 months: +3.5 ETDRS 810 nm SML diffuse LC (n = 6) 3 months: −0.8 ETDRS 6 months: −1.6 ETDRS 514 nm Argon focal LC: (n = 5) 3 months: +4.6 ETDRS 6 m: +3.5 ETDRS 514 nm argon diffuse LC (n = 6): 3 months: −1.7 ETDRS 6 months: +0.6 ETDRS No significant differences between groups | No laser complications were observed in both groups | Not mentioned |
Authors | Year | Eyes | Inclusion criteria | Laser type and parameters | Study design |
---|---|---|---|---|---|
Parodi et al. [56] | 2015 | 35 eyes Group 1: SML: n = 18 Group 2: IVT Bevacizumab (PRN after 3 initial injections)
n = 17 | ME to due BRVO CFT > 250 µm Without non-perfusion ≥ 5 disc areas All eyes were previously treated with conventional grid laser | Iris Medical OcuLight SLX 810 nm, Ø 125 µm, 15% DC, 0.3 s, power: titration | Prospective, randomized, interventional |
Inagaki et al. [57] | 2014 | 32 eyes Group 1: BCVA ≤20/40
n = 15 Group 2: BCVA >20/40
n = 17 | ME due to BRVO (ischemic/non-ischemic) CRT <600 µm No prior macular therapy (LC, IVT etc.) within last 6 months | Iris Medical OcuLight SLX, 810 nm, Ø 200 µm, 15% DC, 0.2 or 0.3 s, Power: 750–1500 mW (90%) for 0.2 s or 360–2000 mW (60%) for 0.3 s | Retrospective, single-center, nonrandomized, interventional case series |
Parodi et al. [58] | 2008 | 24 eyes Group 1: SML only n = 13 Group 2: SML + IVT Triamcinolone n = 11 | ME due to BRVO CRT >212 µm No prior laser treatment Without non-perfusion ≥5 disc areas | Iris Medical OcuLight SLX, 810 nm Ø 125 µm 15% DC, 0.3 s Power: titration | Prospective randomized pilot clinical trial |
Parodi et al. [59] | 2006 | 36 eyes Group 1: SML grid
n = 17 Group 2: Krypton grid
n = 19 | ME due to BRVO CRT >210 µm No prior laser treatment Without non-perfusion ≥5 disc areas | Iris Medical OcuLight SLX 810 nm Ø 125 µm, 10% DC, 0.2 s, power: titration Novus Omni Krypton Ø 100 µm, 0.1 s | Prospective, randomized clinical trial |
Authors | FU (months) | Central retinal thickness | Best corrected visual acuity | Safety | Additional treatments |
---|---|---|---|---|---|
Parodi et al. [56] | 12 | SML group (CFT): BL: 485.5 µm 3 months: 472.0 µm 6 months: 475.0 µm 9 months: 475.0 µm 12 months: 445.0 µm IVT group (CFT): BL: 484.2 µm 3 months: 305.0 µm 6 months: 266.0 µm 9 months: 265.0 µm 12 months: 271.0 µm IVT group significantly better (p = 0.001) | SML group: BL: 0.92 logMAR 3 months: 0.89 logMAR 6 months: 0.89 logMAR 9 months: 0.94 logMAR 12 months: 0.99 logMAR IVT group: BL: 0.94 logMAR 3 months: 0.88 logMAR 6 months: 0.88 logMAR 9 months: 0.85 logMAR 12 months: 0.72 logMAR IVT group significantly better (p = 0.0085) | No laser scars | Not mentioned |
Inagaki et al. [57] | 12 | Group 1: (BCVA ≤20/40 Snellen) BL: 409.3 µm 1 month: 394.3 µm 3 months: 371.3 µm 6 months: 313.5 µm 12 months: 303.5 µm Group 2: (BCVA >20/40 Snellen) BL : 373.3 µm 1 month: 353.5 µm 3 months: 313.1 µm 6 months: 294.1 µm 12 months: 320.1 µm Significant CRT decrease at 3, 6, and 12 months for both groups. No significant difference between the groups at any time point | Group 1: (BCVA ≤ 20/40 Snellen) BL: 0.59 logMAR 1 month: 0.54 logMAR 3 months: 0.54 logMAR 6 months: 0.58 logMAR 12 months: 0.51 logMAR Group 2: (BCVA >20/40 Snellen) BL: 0.13 logMAR 1 month: 0.09 logMAR 3 months: 0.13 logMAR 6 months: 0.09 logMAR 12 months: 0.12 logMAR | No laser scars | Group 1:
n = 8 (53.3%) Group 2:
n = 3 (17.6%) |
Parodi et al. [58] | 12 | SML only: BL: 429 µm 3 months: 364 µm 6 months: 320 µm 9 months: 290 µm 12 months: 278 µm SML + IVT (triamcinolone): BL: 476 µm 3 months: 269 µm 6 months: 276 µm 9 months: 260 µm 12 months: 283 µm Combined SML + IVT showed better response at 3 months (p < 0.001). No difference between groups from 9th month on | SML only: BL: 0.76 logMAR 3 month: 0.78 logMAR 6 months: 0.78 logMAR 9 months: 0.73 logMAR 12 months: 0.65 logMAR SML + IVT (triamcinolone): BL: 0.67 logMAR 3 months: 0.50 logMAR 6 months: 0.45 logMAR 9 months: 0.36 logMAR 12 months: 0.35 logMAR Combined SML + IVT showed significant better response at 9th and 12th months (p < 0.009, p = 0.011, respectively) | No Laser scars | Not mentioned |
Parodi et al. [59] | 24 | SML grid: BL: 480 µm 6 months: 457 µm 12 months: 217 µm 18 months: 215 µm 24 months: 208 µm Krypton grid: BL: 454 µm 6 months: 252 µm 12 months: 226 µm 18 months: 229 µm 24 months: 217 µm Krypton showed better response at 3 months and 6 months (p < 0.001). SML showed better response from 12th month on (p < 0.001) | SML grid: BL: 0.70 logMAR 6 months: 0.70 logMAR 9 months: 0.55 logMAR 12 months: 0.51 logMAR 24 months: 0.49 logMAR Krypton grid: BL: 0.69 logMAR 6 months: 0.60 logMAR 9 months: 0.58 logMAR 12 months 0.57 logMAR 24 m: 0.56 logMAR No statistical difference between groups | No laser scars after SML | Not mentioned |
Central Serous Chorioretinopathy (CSC)
Treatment | Change in CRT (µm) | Change in BCVA (ETDRS letters) | |
---|---|---|---|
CSC | SML | −131 (range −69.7 to −204)a
| 6.34 (range −15 to 20)d
|
PDT | −85 (range −76 to −109.8)b
| 3.87 (range 2 to 8.5)b
| |
Observation | −25 (range 26 to −89)c
| 0.67 (range −2.1 to 2.5)c
| |
DME | SML | −74.9 (range −138 to 48)e
| 1.26 (range −6.6 to 19)e
|
Conventional laser | −43.6 (range −145 to 28.7)f
| −0.29 (range −7.3 to 7.5)f
| |
BRVO | SML | −122.59 (range −272 to −40.5)g
| 2.98 (range −3.5 to 9.5)g
|