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01.07.2020 | Review Article

A review on analysis methods for nerve agent hydrolysis products

verfasst von: Intan Soraya Che Sulaiman, Buong Woei Chieng, Fellyzra Elvya Pojol, Keat Khim Ong, Jahwarhar Izuan Abdul Rashid, Wan Md Zin Wan Yunus, Noor Azilah Mohd Kasim, Norhana Abdul Halim, Siti Aminah Mohd Noor, Victor Feizal Knight

Erschienen in: Forensic Toxicology | Ausgabe 2/2020

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Abstract

Purpose

This review article provides an overview of the background of nerve agents (NAs) and their hydrolysis products. The analytical techniques that are used for the analysis of hydrolysis products are also discussed. The analysis methods include the chromatographic, mass spectrometric, electrophoretic, and sensing technologies that are currently available for the detection of exposure to a number of hydrolysis products of NAs.

Methods

All reviewed information was gathered through a detailed search of Scopus, PubMed, and the World Wide Web using relevant keywords, e.g., NA, hydrolysis products, and methylphosphonic acid.

Results

Most analyses of NA hydrolysis products still rely on chromatographic techniques such as gas and liquid chromatography. Analyses based on mass spectrometry are now fairly routine and can be further improved by providing analyses with precise and accurate masses and faster scan speeds that provide further gains in sensitivity. Although these techniques have high selectivity and sensitivity, most of them are rarely applied to real samples or suffer from destructive real sample analysis. In addition, there is still a lack of studies on the development of portable sensors for the detection of NA hydrolysis products.

Conclusions

Although the analysis of NA hydrolysis products has experienced a transition from qualitative analysis toward rapid and quantitative identification, portable, and fast sensing technologies have not been well established or investigated extensively. In the future, more analysis methods are expected to be developed and may involve the development of sensors and lab-on-chip devices that should address specificity, sensitivity, stability, response time, and repeatability/reproducibility.

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Titel: A review on analysis methods for nerve agent hydrolysis products
verfasst von: Intan Soraya Che Sulaiman
Buong Woei Chieng
Fellyzra Elvya Pojol
Keat Khim Ong
Jahwarhar Izuan Abdul Rashid
Wan Md Zin Wan Yunus
Noor Azilah Mohd Kasim
Norhana Abdul Halim
Siti Aminah Mohd Noor
Victor Feizal Knight
Publikationsdatum: 01.07.2020
Verlag: Springer Singapore
Erschienen in: Forensic Toxicology / Ausgabe 2/2020
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-019-00513-x

Neu im Fachgebiet Rechtsmedizin

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

A review on analysis methods for nerve agent hydrolysis products

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Rechtsmedizin

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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