Background
Methods
Definition and general description of the DPP Suite and modules
Pre-processing
Registration of T1-weighted images
Lesion segmentation and classification
Semi-automatic lesion segmentation
Semi-automatic lesion classification
Registration of lesion masks
Normal appearing tissue segmentation
PWI map generation
DWI map generation
Registration of tissue segmentation and quantitative MRI maps
Data analysis
Graphical User Interface
Process safety and data security
Results
Software metrics
Hardware Host PC | |
CPU | Intel Core i7-4770 |
Ram | 8 Gb |
Hard Disk | SSD + Raid 1 disk |
Software Host PC | |
Operating System | Windows 7 professional |
Virtualization | VMware player 6.0.3 |
Software Guest PC | |
Operating System | Scientific Linux 5.5 |
Reproducibility of results
C1 lesions | C2 lesions | |||||||
---|---|---|---|---|---|---|---|---|
First reader | Second reader |
p value* | Kappa value | First reader | Second reader |
p value* | Kappa value | |
Lesion number (sum, median, IQR, mean ± SD, range) | 4, 0, 0-0, 0.1 ± 0.3, 0-1 | 7, 0, 0-0, 0.2 ± 0.5, 0-2 |
p = 0.242 | 0.692 | 9, 0, 0-0, 0.3 ± 0.6, 0-2 | 12, 0, 0-0, 0.2 ± 0.7, 0-3 |
p = 0.148 | 0.614 |
ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range) | 0, 0-0, 0.1 ± 0.3, 0-0.9 | 0, 0-0, 0.1 ± 0.3, 0-0.9 |
p = 0.256 | 0.792 | 0, 0-0, 0.2 ± 0.4, 0-1.1 | 0, 0-0, 0.1 ± 0.3, 0-1.2 |
p = 0.146 | 0.721 |
CBF ml/100g/min (median, IQR, mean ± SD, range) | 0, 0-0, 15.8 ± 50.2, 0-244.9 | 0, 0-0, 24 ± 59.3, 0-244.9 |
p = 0.2400 | 0.686 | 0, 0-0, 35.3 ± 76.2, 0-342.2 | 0, 0-0, 14.5 ± 39, 0-136.6 |
p = 0.108 | 0.450 |
CBV 100g/min (median, IQR, mean ± SD, range) | 0, 0-0, 0 ± 0, 0-0.2 | 0, 0-0, 0 ± 0.1, 0-0.2 |
p = 0.248 | 0.742 | 0, 0-0, 0 ± 0.1, 0-0.4 | 0, 0-0, 0 ± 0.1, 0-0.3 |
p = 0.114 | 0.464 |
MTT seconds (median, IQR, mean ± SD, range) | 0, 0-0, 0.8 ± 2.8, 0-15.3 | 0, 0-0, 1.1 ± 2.7, 0-11.2 |
p = 0.251 | 0.719 | 0, 0-0, 2 ± 3.8, 0-13.5 | 0, 0-0, 1.2 ± 3.3, 0-13.5 |
p = 0.136 | 0.673 |
C3 lesions | C4 lesions | |||||||
---|---|---|---|---|---|---|---|---|
First reader | Second reader |
p value | Kappa value | First reader | Second reader |
p value | Kappa value | |
Lesion number (sum, median, IQR, mean ± SD, range) | 1075, 18, 5.5-33.8, 28.3 ± 30.8, 0-129 | 1138, 19, 5.5-38.8, 29.9 ± 32.6, 0-132 |
p = 0.446* | 0.921 | 689, 11, 3-21.5, 18.1 ± 22.8, 0-99 | 623, 8, 2-20, 16.4 ± 20.3, 0-87 |
p = 0.420* | 0.904 |
ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range) | 0.9, 0.9-1, 0.9 ± 0.2, 0-1.2 | 0.9, 0.9-1, 0.9 ± 0.2, 0-1.2 |
p = 0.350* | 0.872 | 1, 0.9-1.1, 1 ± 0.2, 0-1.2 | 1, 0.9-1.1, 1 ± 0.2, 0-1.3 |
p = 0.448* | 0.812 |
CBF ml/100g/min (median, IQR, mean ± SD, range) | 131.6, 88.6-183.8, 137.5 ± 60.2, 0-295.9 | 139.3, 99.9-191.1, 141.8 ± 58.8, 0-295.9 |
p = 0.376** | 0.844 | 124.3, 84.8-165.9, 124.6 ± 58.5, 0-263 | 105.5, 76.5-150, 115.1 ± 59.6, 0-270.8 |
p = 0.243** | 0.848 |
CBV 100g/min (median, IQR, mean ± SD, range) | 0.1, 0.1-0.2, 0.1 ± 0, 0-0.3 | 0.1, 0.1-0.2, 0.1 ± 0, 0-0.3 |
p = 0.500** | 0.824 | 0.1, 0.1-0.2, 0.1 ± 0.1, 0-0.3 | 0.1, 0.1-0.1, 0.1 ± 0.1, 0-0.3 |
p = 0.181** | 0.769 |
MTT seconds (median, IQR, mean ± SD, range) | 8.3, 6.9-9, 8 ± 2.2, 0-12.1 | 8.1, 6.6-8.6, 7.8 ± 2.2, 0-12.1 |
p = 0.384** | 0.836 | 8.4, 6.8-9.7, 8.2 ± 2.6, 0-15 | 8.4, 6.8-9.7, 81. ± 2.9, 0-15 |
p = 0.463** | 0.828 |