Impacts on practice
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It is important for optimal pharmaceutical care that the pharmacist has knowledge about interactions between food and citrus fruit juice and medicines to treat bladder dysfunction.
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Of the medicines to treat bladder dysfunction, only the effect of trospium was found to be significantly affected by food therefore the medication should be administered on an empty stomach.
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The majority of medicines to treat bladder dysfunction may potentially interact with grapefruit and other citrus fruit juice, and the effects of such interactions may be negative for patients.
Introduction
Aim of the review
Method
Results and discussion
Anticholinergic drugs
Darifenacin
Fesoterodine
Oxybutynin
Solifenacin
Tolterodine
Trospium
β3 adrenoceptor agonist
Mirabegron
Drug | Drug–food interaction | Recommendations |
---|---|---|
Darifenacin | Potential interaction with grapefruit juice | May be taken irrespectively of a meal Exercise caution while consuming grapefruit juice during therapy |
Fesoterodine | Potential interaction with grapefruit juice | May be taken irrespectively of a meal Avoid consumption of grapefruit juice during therapy |
Oxybutynin | Potential interaction with grapefruit juice | May be taken irrespectively of a meal In patients manifesting disturbances of saliva secretion during therapy, taking the drug 0.5–1 h prior to a planned meal is recommended Exercise caution while consuming grapefruit juice during therapy |
Solifenacin | Potential interaction with grapefruit juice | May be taken irrespectively of a meal Grapefruit juice should not be consumed during solifenacin therapy |
Tolterodine | Data unavailable | May be taken irrespectively of a meal |
Trospium | Food, especially high in fats, decreases absorption of the drug | To be taken 1 h prior to a meal or on an empty stomach |
Mirabegron | Data unavailable | May be taken irrespectively of a meal |