Introduction
Materials and methods
Study design
Imaging and MRI-guided biopsies
Data analysis
Statistical analyses
Results
Patients and lesions
Lesion type | n | Mean diameter (mm) | Histology | n | Mean diameter (mm) |
---|---|---|---|---|---|
Mass lesions | 270 | 9±5 (SD) | Malignant | 68 | 11±6 (SD) |
Benign | 202 | 9±5 (SD) | |||
Non-mass lesions | 199 | 26±15 (SD) | Malignant | 30 | 35±16 (SD) |
Benign | 169 | 24±14 (SD) | |||
Total | 469 | 16±13 (SD) | Malignant | 98 | 18±15 (SD) |
Benign | 371 | 16±12 (SD) |
Node
| Benign | High-risk | DCIS | Invasive cancer | Total | |
---|---|---|---|---|---|---|
1
| n | 69 | 8 | 0 | 0 | 77 |
% |
89.6
|
10.4
|
0.0
|
0.0
| ||
2
| n | 23 | 3 | 0 | 0 | 26 |
% |
88.5
|
11.5
|
0.0
|
0.0
| ||
3
| n | 154 | 45 | 9 | 9 | 209 |
% |
73.7
|
21.5
|
4.3
|
4.3
| ||
4
| n | 11 | 1 | 0 | 1 | 13 |
% |
84.6
|
7.7
|
0.0
|
7.7
| ||
5
| n | 31 | 9 | 10 | 8 | 58 |
% |
53.4
|
15.5
|
17.2
|
13.8
| ||
7
| n | 10 | 4 | 5 | 9 | 28 |
% |
35.7
|
14.3
|
17.9
|
32.1
| ||
8
| n | 10 | 6 | 6 | 2 | 24 |
% |
41.7
|
25.0
|
25.0
|
8.3
| ||
9
| n | 4 | 1 | 1 | 11 | 17 |
% |
23.5
|
5.9
|
5.9
|
64.7
| ||
10
| n | 3 | 0 | 2 | 5 | 10 |
% |
30.0
|
0.0
|
20.0
|
50.0
| ||
11
| n | 1 | 0 | 0 | 6 | 7 |
% |
14.3
|
0.0
|
0.0
|
85.7
| ||
∑ |
n
|
316
|
77
|
31
|
45
|
469
|
% |
67
.
4
|
16
.
4
|
6
.
6
|
9
.
6
|
100
.
0
|
ROC curve analyses
All lesions | ||||||
---|---|---|---|---|---|---|
Cut-off | Sens | 95% CI | Spec | 95% CI | +LR | −LR |
≥1 | 100% (98/98) | 96.3–100 | 0% (0/371) | 0–1 | 1 | |
>2 | 100% (98/98) | 96.3–100 | 27.8% (103/371) | 23.3–32.6 | 1.38 | 0 |
>3 | 81.6% (80/98) | 72.5–88.7 | 79.3% (294/371) | 74.8–83.3 | 3.93 | 0.23 |
>4 | 80.6% (79/98) | 71.4–87.9 | 82.5% (306/371) | 78.2–86.2 | 4.6 | 0.24 |
>5 | 61.2% (60/98) | 50.8–70.9 | 93% (345/371) | 89.9–95.4 | 8.74 | 0.42 |
>7 | 40.8% (40/98) | 31.0–51.2 | 95.2% (353/371) | 92.4–97.1 | 8.41 | 0.62 |
>8 | 30.6% (30/98) | 21.7–40.7 | 99% (367/371) | 97.3–99.7 | 28.39 | 0.7 |
>9 | 16.3% (16/98) | 9.6–25.2 | 99.7% (370/371) | 98.5–100 | 60.57 | 0.84 |
>10 | 7.1% (7/98) | 2.9–14.2 | 100% (371/371) | 99–100 | 0.93 | |
>11 | 0% (0/98) | 0–3.7 | 100% (371/371) | 99–100 | 1 |
Mass lesions | ||||||
---|---|---|---|---|---|---|
Cut-off | Sens | 95% CI | Spec | 95% CI | +LR | −LR |
≥1 | 100% (68/68) | 94. 7–100 | 0% (0/202) | 0–1.8 | 1 | |
>2 | 100% (68/68) | 94.7–100 | 49% (99/202) | 41.9–56.1 | 1.96 | 0 |
>3 | 88.2% (60/68) | 78.1–94.8 | 72.3% (146/202) | 65.6–78.3 | 3.18 | 0.16 |
>4 | 86.8% (59/68) | 76.4–93.8 | 78.2% (158/202) | 71.9–83.7 | 3.98 | 0.17 |
>5 | 75% (51/68) | 63–84.7 | 89.1% (180/202) | 84–93 | 6.89 | 0.28 |
>7 | 50% (34/68) | 37.6–62.4 | 92.6% (187/202) | 88–95.8 | 6.73 | 0.54 |
>8 | 42.7% (29/68) | 30.7–55.2 | 98% (198/202) | 95–99.5 | 21.54 | 0.59 |
>9 | 23.5% (16/68 | 14.1–35.4 | 99.5% (201/202) | 97.3–100 | 47.53 | 0.77 |
>10 | 10.3% (7/68) | 4.2–20.1 | 100% (202/202) | 98.2–100 | 0.9 | |
>11 | 0% (0/68) | 0–5.3 | 100% (202/202) | 98.2–100 | 1 |
Non-mass lesions | ||||||
---|---|---|---|---|---|---|
Cut-off | Sens | 95% CI | Spec | 95% CI | +LR | -LR |
≥1 | 100% (30/30) | 88.4–100 | 0% | 0–2.2 | 1 | |
>2 | 100% (30/30) | 88.4–100 | 2.37% (4/169) | 0.6–5.9 | 1.02 | 0 |
>3 | 66.67% (20/30) | 47.2–82.7 | 87.57% (148/169) | 81.6–92.1 | 5.37 | 0.38 |
>5 | 30% (9/30) | 14.7–49.4 | 97.63% (165/169) | 94.1–99.4 | 12.67 | 0.72 |
>7 | 20% (6/30) | 7.7–38.6 | 98.22% (166/169) | 94.9–99.6 | 11.27 | 0.81 |
>8 | 3.33% (1/30) | 0.1–17.2 | 100% (169/169) | 97.8–100 | 0.97 | |
>9 | 0% (0/30) | 0–11.6 | 100% (169/169) | 97.8–100 | 1 |