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13.09.2017 | Original Research | Ausgabe 4/2017 Open Access

Infectious Diseases and Therapy 4/2017

A Single-Center Retrospective Cohort Analysis of Maternal and Infant Outcomes in HIV-Infected Mothers Treated with Integrase Inhibitors During Pregnancy

Zeitschrift:
Infectious Diseases and Therapy > Ausgabe 4/2017
Autoren:
Monique L. Mounce, Laura Pontiggia, Jessica L. Adams
Wichtige Hinweise
Monique L. Mounce: At the time of research, Monique Mounce was a Postgraduate Year 2 Pharmacotherapy Resident at Philadelphia College of Pharmacy and Cooper University Hospital. She completed the manuscript writing and submission as an Assistant Professor at the Notre Dame of Maryland University School of Pharmacy.

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Abstract

Introduction

Integrase strand transfer inhibitors (INSTI) are currently being investigated for the treatment of HIV in pregnancy. The purpose of this study is to evaluate the differences in maternal and infant outcomes in HIV-positive mothers treated with INSTI-containing antiretroviral therapy (ART) during pregnancy compared to protease inhibitor (PI)-containing ART.

Methods

A retrospective, cohort study of INSTI- and PI-based ART used in pregnancy between 2007 and 2015 was performed. The primary objective was to evaluate the differences in viral load (VL) suppression prior to delivery. Secondary endpoints included time to and duration of VL suppression and safety parameters in both mothers and infants. For the primary analysis, the two arms were matched 1:2 INSTI to PI based on the presence or absence of viremia at the time of pregnancy determination. Additional analysis was performed on the entire matched and unmatched dataset.

Results

Twenty-one patients were matched (7 INSTI and 14 PI). There were no significant differences between groups with respect to the proportion of patients with VL suppression prior to delivery (71.4% INSTI vs. 92.9% PI, p = 0.247), and there were no significant differences in any of the secondary endpoints. Patients with documented adherence issues were statistically more likely to not be virologically suppressed prior to delivery (p = 0.002).

Conclusion

No differences in efficacy or safety were found between patients treated with INSTIs compared to PIs. This study supports the further investigation of the use of INSTIs during pregnancy to reduce HIV transmission.
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