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International Archives of Occupational and Environmental Health

Erschienen in:

21.05.2019 | Original Article

A study of atherothrombotic biomarkers in welders

verfasst von: Dag G. Ellingsen, Maxim Chashchin, Ingebjørg Seljeflot, Balazs Berlinger, Valery Chashchin, Leo Stockfelt, Yngvar Thomassen

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 7/2019

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Abstract

Introduction

Studies have shown that welders have increased cardiovascular mortality. This may be due to airborne particulate matter (PM) exposure. Elevated levels of PM in polluted urban air have been associated with increased cardiovascular mortality and morbidity. This study seeks to explore potential mechanisms for the increased cardiovascular mortality in welders.

Methods

Seventy welders were compared to 74 referents. Exposure to PM was assessed by personal full-shift sampling of work room air the last 2 days before collection of blood samples. Selected biomarkers of pro-coagulant activity, endothelial/platelet activation and systemic inflammation were determined in the samples.

Results

The welders had been occupationally exposed to PM for 15 years on average. The geometric mean current exposure to PM was 8.1 mg/m³. They had statistically significantly higher concentrations of TNF-α, P-selectin, CD40L, prothrombin fragment 1 + 2 and d-dimer than the referents. Increasing concentrations of d-dimer and CD40L were observed by increasing current exposure to PM.

Discussion

The study shows that welders highly exposed to welding PM were in a pro-thrombotic state with increased thrombin generation and consequently higher d-dimer concentrations. The welders had also increased endothelial/platelet activation as compared to the referents. These alterations are compatible with increased cardiovascular mortality as previously reported among welders.

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Titel: A study of atherothrombotic biomarkers in welders
verfasst von: Dag G. Ellingsen
Maxim Chashchin
Ingebjørg Seljeflot
Balazs Berlinger
Valery Chashchin
Leo Stockfelt
Yngvar Thomassen
Publikationsdatum: 21.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 7/2019
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-019-01441-4

Springer Medizin

Abstract

Introduction

Methods

Results

Discussion

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