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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Journal of Orthopaedic Surgery and Research 1/2017

A study to compare the efficacy of polyether ether ketone rod device with titanium devices in posterior spinal fusion in a canine model

Zeitschrift:
Journal of Orthopaedic Surgery and Research > Ausgabe 1/2017
Autoren:
Nanxiang Wang, Huanxin Xie, Chunyang Xi, Han Zhang, Jinglong Yan
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s13018-017-0543-x) contains supplementary material, which is available to authorized users.

Abstract

Background

The benefits of posterior lumbar fusion surgery with orthotopic paraspinal muscle-pediculated bone flaps are well established. However, the problem of non-union due to mechanical support is not completely resolved. The aim of the study was to compare the efficacy of polyether ether ketone (PEEK) rod device with conventional titanium devices in the posterior lumbar fusion surgery with orthotopic paraspinal muscle-pediculated bone flaps.

Methods

This was a randomized controlled study with an experimental animal model. Thirty-two mongrel dogs were randomly divided into two groups—control group (n = 16), which received the titanium device and the treatment group (n = 16), which received PEEK rods. The animals were sacrificed 8 or 16 weeks after surgery. Lumbar spines of dogs in both groups were removed, harvested, and assessed for radiographic, biomechanical, and histological changes.

Results

Results in the current study indicated that there was no significant difference in the lumbar spine of the control and treatment groups in terms of radiographic, manual palpation, and gross examination. However, certain parameters of biomechanical testing showed significant differences (p < 0.05) in stiffness and displacement, revealing a better fusion (treatment group showed decreased stiffness with decreased displacement) of the bone graft. Similarly, the histological analysis also revealed a significant fusion mass in both treatment and control groups (p < 0.05).

Conclusions

These findings revealed that fixation using PEEK connecting rod could improve the union of the bone graft in the posterior lumbar spine fusion surgery compared with that of the titanium rod fixation.
Zusatzmaterial
Additional file 1: Figure S1. A. The bone graft bed of the novel posterior spinal fusion model. B. The in situ operation situation of the treatment group (the PEEK rod device and bone graft). C. The in situ operation situation of the control group (the titanium rod device and bone graft). (TIF 3331 kb)
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Additional file 3: Figure S3. A, B. Radiographs in the treatment group (8 weeks). C, D. Radiographs in the treatment group (16 weeks). E, F. Radiographs in the control group (8 weeks). G, H. Radiographs in the control group (16 weeks). (TIF 1742 kb)
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Additional file 4: Figure S4. A, B. Sagittal and coronal 3-dimension CT scan image in the treatment group (8 weeks). C, D. Sagittal and coronal 3-dimension CT scan image in the treatment group (16 weeks). E, F. Sagittal and coronal 3-dimension CT scan image in the control group (8 weeks). G, H. Sagittal and coronal 3-dimension CT scan image in the control group (16 weeks). (TIF 1027 kb)
13018_2017_543_MOESM4_ESM.tif
Additional file 5: Figure S5. A. Photo of the L1–7 specimen in the treatment group (8 weeks). B. Photo of the L1–7 specimen in the treatment group (16 weeks). C. Photo of the L1–7 specimen in the control group (8 weeks). D. Photo of the L1-7 specimen in the control group (16 weeks). (TIF 3807 kb)
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Additional file 6: Figure S6. The histologic section of the graft in the control group (8 weeks) in the fusion site (H&E × 10). (TIF 3517 kb)
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Additional file 7: Figure S7. The histologic section of the graft in the control group (16 weeks) in the fusion site (H&E × 10). (TIF 3517 kb)
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Additional file 8: Figure S8. The histologic section of the graft in the treatment group (8 weeks) in the fusion site (H&E × 10). (TIF 3516 kb)
13018_2017_543_MOESM8_ESM.tif
Additional file 9: Figure S9. The histologic section of the graft in the treatment group (16 weeks) in the fusion site (H&E × 10). (TIF 3512 kb)
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Literatur
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