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Erschienen in: International Urology and Nephrology 10/2015

01.10.2015 | Urology - Original article

A suggestion for pathological grossing and reporting based on prognostic indicators of malignancies from a pooled analysis of renal epithelioid angiomyolipoma

verfasst von: Shan Zheng, Xin-gang Bi, Qing-kun Song, Zheng Yuan, Lei Guo, Hongtu Zhang, Jian-hui Ma

Erschienen in: International Urology and Nephrology | Ausgabe 10/2015

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Abstract

Purpose

Epithelioid angiomyolipoma (EAML) is a rare entity of the kidney. The guideline for grossing and reporting of renal EAML has not been established for Chinese patients. We planned this study to provide some preliminary indicators for draft guidelines of pathological diagnosis among Chinese people.

Methods

The histopathological characteristics of 11 EAML cases from Cancer Hospital, Chinese Academy of Medical Sciences, were reviewed, and a pooled analysis based on our cases and cases from published articles was performed on the histopathological characteristics and prognosis of 56 Chinese patients with EAML. All the cases met the criteria of the 2004 World Health Organization classification of renal tumors.

Results

The ratio of female to male was 1.2:1 with the mean age of 43.4 in the 11 cases. All the 11 cases were sampled following the guideline of renal cell carcinoma. The mean tumor size was 6.5 cm. Four (36.4 %) cases showed necrosis. Six (54.5 %) cases showed invasive borders. Only one case showed metastases. In pooled analysis of the total 56 cases with EAML, 10 cases (17.9 %) showed adverse prognosis. Tumor size, necrosis and invasive edge showed significant difference between favorite and adverse prognostic groups (P < 0.05).

Conclusion

The majority of EAML is benign, and true malignant EAML is rare. The sample of EAML should follow the sample guidelines of renal cell carcinoma with some modifications, emphasizing the presence of necrosis and invading edge. The information of tumor size, necrosis and invasive edge should be included in the diagnostic report of each EAML case.
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Metadaten
Titel
A suggestion for pathological grossing and reporting based on prognostic indicators of malignancies from a pooled analysis of renal epithelioid angiomyolipoma
verfasst von
Shan Zheng
Xin-gang Bi
Qing-kun Song
Zheng Yuan
Lei Guo
Hongtu Zhang
Jian-hui Ma
Publikationsdatum
01.10.2015
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 10/2015
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-015-1079-9

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