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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 9/2022

20.08.2022 | Original Article

A systematic review and meta-analysis on the accuracy of rapid immunochromatographic tests for dengue diagnosis

verfasst von: Jéssica V. L. Macêdo, Isaac A. M. Frias, Maria D. L. Oliveira, Fernando Zanghelini, César A. S. Andrade

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2022

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Abstract

Rapid immunochromatographic tests are frequently used to diagnose dengue due to their easy use, low cost, and fast response. A high level of accuracy is essential for rapid diagnostic tests to support their large-scale use. Thus, this systematic review aims to evaluate the accuracy of rapid dengue diagnostic tests. The investigation was run through the following databases: LILACS, Medline (Pubmed), CRD, The Cochrane Library, Trip Medical Database, and Google Scholar. To solve difficulties, two independent reviewers performed document screening and selection. ELISA assay was adopted as a reference test because of several methodologic advantages. Seventeen articles were included accordingly, reckoning 6837 participating individuals. The receiver operating characteristic (ROC) and Forest Plot were conducted to evaluate the sensitivity and specificity for each analyzed parameter (anti-dengue IgM, IgG, and NS1 antigen). The risk of bias and quality of evidence were assessed as moderate using QUADAS-2 and Grading of Recommendations Assessment, Development, and Evaluation (GRADE), respectively. The sensitivity of IgM concerning the studied tests ranged from 13.8 to 90%, while that of NS1 ranged from 14.7 to 100% (95% CI). The antibodies with NS1 presented increased sensitivity; pooled data show that the association of the three analytes bestows the best result, with a combined sensitivity of 90% (CI 95%: 87–92%) and a pooled specificity of 89% (CI 95%: 87–92%). Thus, the present review provides relevant knowledge for decision-making between available rapid diagnostic tests.
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Metadaten
Titel
A systematic review and meta-analysis on the accuracy of rapid immunochromatographic tests for dengue diagnosis
verfasst von
Jéssica V. L. Macêdo
Isaac A. M. Frias
Maria D. L. Oliveira
Fernando Zanghelini
César A. S. Andrade
Publikationsdatum
20.08.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 9/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-022-04485-6

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