Background
Methods
Eligibility criteria
Data sources and search strategies
Study selection
Data extraction
Methodologic quality and risk of bias
Analysis
Subgroup analysis
Sensitivity analysis
Certainty in the evidence
Results
Study selection
Study characteristics
Author, year | Intervention (dose, schedule) | Comparison (description) | Patients (N) | Age (years) | Male (%) | IPSS classification intervention | IPSS classification comparison | Follow-up (months) |
---|---|---|---|---|---|---|---|---|
Azacitidine | ||||||||
Fenaux, 2009 [10] | Azacitidine: subcutaneously 75 mg/m2/day for 7 days Q 28 days for at least six cycles | BSC, low-dose Ara-C 20 mg/m2, intensive chemotherapy, or mitoxantrone | Intervention: 179 Comparison: 179 | Intervention: 69 (42–83) Comparison: 70 (38–88) | NR | Intermediate-1: 5 (3%) Intermediate-2: 76 (43%) High: 82 (46%) | Intermediate-1: 13 (7%) Intermediate-2: 70 (39%) High: 85 (48%) | 42 |
Silverman, 2002 [19] | Azacitidine: subcutaneously 75 mg/m2/day for 7 days Q 28 days for at least six cycles | Supportive care with antibiotics and transfusions | Intervention: 99 Comparison: 92 | Intervention: 69 (31–92) Comparison: 67 (35–88) | Intervention: 71.05 Comparison: 63.27 | Low*: 2 (2%) Intermediate-1: 21 (26%) Intermediate-2: 9 (11%) High: 7 (9%) | Low*: 5 (6%) Intermediate-1: 16 (20%) Intermediate-2: 13 (16%) High: 8 (10%) | 53 |
Decitabine | ||||||||
Kantarjian, 2006 [21] | Decitabine: intravenously 15 mg/m2 Q 8 h for 3 days, every 6 weeks | BSC | Intervention: 89 Comparison: 81 | Intervention: 70 (65–76) Comparison: 70 (62–74) | Intervention: 66.29 Comparison: 70.37 | Intermediate-1: 28 (31%) Intermediate-2: 38 (43%) High: 23 (26%) | Intermediate-1: 24 (30%) Intermediate-2: 36 (44%) High: 21 (26%) | 30 |
Lubbert, 2011 [11] | Decitabine: intravenously 15 mg/m2 Q 8 h for 3 days, every 6 weeks | BSC | Intervention: 119 Comparison: 114 | Intervention: 69 (60–90) Comparison: 70 (60–86) | Intervention: 63.87 Comparison: 64.04 | Intermediate-1: 8 (6.7%) Intermediate-2: 64 (53.8%) High: 46 (38.7%) | Intermediate-1: 8 (7%) Intermediate-2: 63 (55.3%) High: 42 (36.8%) | 30 |