Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende Patientenratgeber
Erweiterte Suche
Anmelden
nach oben
Supportive Care in Cancer
Erschienen in:

22.07.2017 | Original Article

A systematic review of dental disease management in cancer patients

verfasst von: Catherine H. L. Hong, Shijia Hu, Thijs Haverman, Monique Stokman, Joel J. Napeñas, Jacolien Bos-den Braber, Erich Gerber, Margot Geuke, Emmanouil Vardas, Tuomas Waltimo, Siri Beier Jensen, Deborah P. Saunders

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Introduction

This systematic review aims to update on the prevalence of odontogenic-related infections and the efficacy of dental strategies in preventing dental-related complications in cancer patients since the 2010 systematic review.

Review method

A literature search was conducted in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 2009 and 30 June 2016. Each study was assessed by 2 reviewers and the body of evidence for each intervention was assigned an evidence level.

Results

After examination of the abstracts and full-text articles, 59 articles satisfied the inclusion criteria. The weighted prevalence of dental infections and pericoronitis during cancer therapy was 5.4 and 5.3%, respectively. The frequency of dental-related infections during intensive chemotherapy after complete, partial, and minimal pre-cancer dental evaluation/treatment protocols ranged from 0 to 4%. Protocols involving third molars extractions had the highest complications (40%).

Conclusions

In view of the low prevalence of infections and the potential for complications after third molar extractions, it is suggested that partial dental evaluation/treatment protocols prior to intensive chemotherapy; whereby minor caries (within dentin), asymptomatic third molars or asymptomatic teeth without excessive probing depth (<8 mm), mobility (mobility I or II) or with periapical lesions of <5 mm were observed; is a viable option when there is insufficient time for complete dental evaluation/treatment protocols. The use of chlorhexidine, fluoride mouth rinses as well as composite resin, resin-modified glass ionomer cement (GIC), and amalgam restorations over conventional GIC in post head and neck radiation patients who are compliant fluoride users is recommended.
Literatur
1.
2.
Institute NC (Asesssed 25th May 2016) Oral complications of chemotherapy and head /neck radiation
3.
Hong CH, Napenas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS, Spijkervet FK, Brennan MT, Dental Disease Section OCSGM-nAoSCiCISoOO (2010) A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer 18(8):1007–1021. doi:10.​1007/​s00520-010-0873-2 CrossRefPubMedPubMedCentral
4.
Graber CJ, de Almeida KN, Atkinson JC, Javaheri D, Fukuda CD, Gill VJ, Barrett AJ, Bennett JE (2001) Dental health and viridans streptococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant 27(5):537–542. doi:10.​1038/​sj.​bmt.​1702818 CrossRefPubMed
5.
Lark RL, McNeil SA, VanderHyde K, Noorani Z, Uberti J, Chenoweth C (2001) Risk factors for anaerobic bloodstream infections in bone marrow transplant recipients. Clin Infect Dis 33(3):338–343. doi:10.​1086/​322595 CrossRefPubMed
6.
7.
Glenny AM, Gibson F, Auld E, Coulson S, Clarkson JE, Craig JV, Eden OB, Worthington HV, Pizer B, Group U-PMC (2004) A survey of current practice with regard to oral care for children being treated for cancer. Eur J Cancer 40(8):1217–1224. doi:10.​1016/​j.​ejca.​2004.​01.​030 CrossRefPubMed
8.
9.
Schuurhuis JM, Stokman MA, Roodenburg JL, Reintsema H, Langendijk JA, Vissink A, Spijkervet FK (2011) Efficacy of routine pre-radiation dental screening and dental follow-up in head and neck oncology patients on intermediate and late radiation effects. A retrospective evaluation. Radiother Oncol 101(3):403–409. doi:10.​1016/​j.​radonc.​2011.​09.​018 CrossRefPubMed
10.
Cankar K, Finderle Z, Jan J (2011) The effect of hyperbaric oxygenation on postradiation xerostomia and saliva in patients with head and neck tumours. Caries Res 45(2):136–141. doi:10.​1159/​000324811 CrossRefPubMed
11.
Sommerfield MRPJ, Pfister DG, Bennett CL, Recht A, Smith TJ, Weeks JC, Winn RJ, Durant JR (2000) ASCO clinical practice guidelines: process, progress, pitfalls, and prospects. Class Pap Curr Comments 4:881–886
12.
Hadorn DC, Baker D, Hodges JS, Hicks N (1996) Rating the quality of evidence for clinical practice guidelines. J Clin Epidemiol 49(7):749–754CrossRefPubMed
13.
Ardizzoni A, Pennucci MC, Danova M, Viscoli C, Mariani GL, Giorgi G, Venturini M, Mereu C, Scolaro T, Rosso R (1996) Phase I study of simultaneous dose escalation and schedule acceleration of cyclophosphamide-doxorubicin-etoposide using granulocyte colony-stimulating factor with or without antimicrobial prophylaxis in patients with small-cell lung cancer. Br J Cancer 74(7):1141–1147CrossRefPubMedPubMedCentral
14.
Baliga AM, Brave VR, Vyas HA (1995) Oral mucosal lesions in patients with acute leukemias and related disorders due to cytotoxic therapy. J Indian Soc Pedod Prev Dent 13(1):25–29PubMed
15.
Fayle SA, Curzon ME (1991) Oral complications in pediatric oncology patients. Pediatr Dent 13(5):289–295PubMed
16.
Toljanic JA, Bedard JF, Larson RA, Fox JP (1999) A prospective pilot study to evaluate a new dental assessment and treatment paradigm for patients scheduled to undergo intensive chemotherapy for cancer. Cancer 85(8):1843–1848CrossRefPubMed
17.
El-Housseiny AA, Saleh SM, El-Masry AA, Allam AA (2007) Assessment of oral complications in children receiving chemotherapy. J Clin Pediatr Dent 31(4):267–273CrossRefPubMed
18.
19.
Gurgan CA, Ozcan M, Karakus O, Zincircioglu G, Arat M, Soydan E, Topcuoglu P, Gurman G, Bostanci HS (2013) Periodontal status and post-transplantation complications following intensive periodontal treatment in patients underwent allogenic hematopoietic stem cell transplantation conditioned with myeloablative regimen. Int J Dent Hyg 11(2):84–90. doi:10.​1111/​j.​1601-5037.​2012.​00550.​x CrossRefPubMed
20.
Haytac MC, Dogan MC, Antmen B (2004) The results of a preventive dental program for pediatric patients with hematologic malignancies. Oral Health Prev Dent 2(1):59–65PubMed
21.
22.
Raut A, Huryn JM, Hwang FR, Zlotolow IM (2001) Sequelae and complications related to dental extractions in patients with hematologic malignancies and the impact on medical outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92(1):49–55. doi:10.​1067/​moe.​2001.​113588 CrossRefPubMed
23.
Tai CC, Precious DS, Wood RE (1994) Prophylactic extraction of third molars in cancer patients. Oral Surg Oral Med Oral Pathol 78(2):151–155CrossRefPubMed
24.
25.
Yamagata K, Onizawa K, Yanagawa T, Hasegawa Y, Kojima H, Nagasawa T, Yoshida H (2006) A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation. Bone Marrow Transplant 38(3):237–242. doi:10.​1038/​sj.​bmt.​1705429 CrossRefPubMed
26.
Yamagata K, Onizawa K, Yanagawa T, Takeuchi Y, Hasegawa Y, Chiba S, Bukawa H (2011) Prospective study establishing a management plan for impacted third molar in patients undergoing hematopoietic stem cell transplantation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111(2):146–152. doi:10.​1016/​j.​tripleo.​2010.​09.​006 CrossRefPubMed
27.
Yamagata K, Onizawa K, Yoshida H, Yamagata K, Kojima Y, Koike K, Tsuchida M (2006) Dental management of pediatric patients undergoing hematopoietic stem cell transplant. Pediatr Hematol Oncol 23(7):541–548. doi:10.​1080/​0888001060081418​7 CrossRefPubMed
28.
29.
Thariat J, Ramus L, Darcourt V, Marcy PY, Guevara N, Odin G, Poissonnet G, Castillo L, Ali AM, Righini C (2012) Compliance with fluoride custom trays in irradiated head and neck cancer patients. Support Care Cancer 20(8):1811–1814. doi:10.​1007/​s00520-011-1279-5 CrossRefPubMed
30.
Meca LB, Souza FR, Tanimoto HM, Castro AL, Gaetti-Jardim Junior E (2009) Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy. J Appl Oral Sci 17(Suppl):5–12CrossRefPubMedPubMedCentral
31.
32.
De Moor RJ, Stassen IG, van’t Veldt Y, Torbeyns D, Hommez GM (2011) Two-year clinical performance of glass ionomer and resin composite restorations in xerostomic head- and neck-irradiated cancer patients. Clin Oral Investig 15(1):31–38. doi:10.​1007/​s00784-009-0355-4 CrossRefPubMed
33.
McComb D, Erickson RL, Maxymiw WG, Wood RE (2002) A clinical comparison of glass ionomer, resin-modified glass ionomer and resin composite restorations in the treatment of cervical caries in xerostomic head and neck radiation patients. Oper Dent 27(5):430–437PubMed
34.
Wood RE, Maxymiw WG, McComb D (1993) A clinical comparison of glass ionomer (polyalkenoate) and silver amalgam restorations in the treatment of Class 5 caries in xerostomic head and neck cancer patients. Oper Dent 18(3):94–102PubMed
35.
36.
37.
Beer KT, Zehnder D, Lussi A, Greiner RH (2002) Sparing of contralateral major salivary glands has a significant effect on oral health in patients treated with radical radiotherapy of head and neck tumors. Strahlenther Onkol 178:722–6CrossRefPubMed
38.
Leung WK, Jin LJ, Samaranayake LP, Chiu GK (1998) Subgingival microbiota of shallow periodontal pockets in individuals after head and neck irradiation. Oral Microbiol Immunol 13(1):1–10CrossRefPubMed
39.
Meng L, Liu J, Peng B, Fan M, Nie M, Chen Z, Gan Y, Bian Z (2005) The persistence of Streptococcus mutans in nasopharyngeal carcinoma patients after radiotherapy. Caries Res 39(6):484–489. doi:10.​1159/​000088184 CrossRefPubMed
40.
Srithavaj T, Thaweboon S (2006) Determination of oral microflora in irradiated ocular deformed children. Southeast Asian J Trop Med Public Health 37(5):991–995PubMed
41.
Dens F, Boogaerts M, Boute P, Declerck D, Demuynck H, Vinckier F, Belgium B (1996) Caries-related salivary microorganisms and salivary flow rate in bone marrow recipients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81(1):38–43CrossRefPubMed
42.
Jensen SB, Mouridsen HT, Bergmann OJ, Reibel J, Brunner N, Nauntofte B (2008) Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(2):217–226. doi:10.​1016/​j.​tripleo.​2008.​04.​003 CrossRefPubMed
43.
44.
Meurman JH, Laine P, Lindqvist C, Teerenhovi L, Pyrhonen S (1997) Five-year follow-up study of saliva, mutans streptococci,lactobacilli and yeast counts in lymphoma patients. Oral Oncol 33(6):439–443CrossRefPubMed
45.
O’Sullivan EA, Duggal MS, Bailey CC, Curzon ME, Hart P (1993) Changes in the oral microflora during cytotoxic chemotherapy in children being treated for acute leukemia. Oral Surg Oral Med Oral Pathol 76(2):161–168CrossRefPubMed
46.
Ou-Yang LW, Chang PC, Tsai AI, Jaing TH, Lin SY (2010) Salivary microbial counts and buffer capacity in children with acute lymphoblastic leukemia. Pediatr Dent 32(3):218–222PubMed
47.
48.
Olszewska K, Mielnik-Blaszczak M (2016) An assessment of the number of cariogenic bacteria in the saliva of children with chemotherapy-induced neutropenia. Adv Clin Exp Med 25(1):11–19. doi:10.​17219/​acem/​28998 CrossRefPubMed
49.
Meurman JH, Laine P, Lindqvist C, Teerenhovi L, Pyrhonen S (1997) Five-year follow-up study of saliva, mutans streptococci, lactobacilli and yeast counts in lymphoma patients. Oral Oncol 33(6):439–443CrossRefPubMed
50.
Allareddy V, Prakasam S, Allareddy V, Martinez-Schlurmann NI, Rampa S, Nalliah RP, Eswaran SV, Elangovan S (2015) Poor oral health linked with increased risk of infectious complications in adults with leukemia. J Mass Dent Soc 64(3):38–42PubMed
Metadaten
Titel
A systematic review of dental disease management in cancer patients
verfasst von
Catherine H. L. Hong
Shijia Hu
Thijs Haverman
Monique Stokman
Joel J. Napeñas
Jacolien Bos-den Braber
Erich Gerber
Margot Geuke
Emmanouil Vardas
Tuomas Waltimo
Siri Beier Jensen
Deborah P. Saunders
Publikationsdatum
22.07.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 1/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-017-3829-y

Weitere Artikel der Ausgabe 1/2018

Beyond death and dying: how Chinese spouses navigate the final days with their loved ones suffering from terminal cancer

  • Original Article

Shared decision-making in palliative care: desires and facts

  • Letter to the editor

Expert agreed standards for the selection and development of cancer support group leaders: an online reactive Delphi study

  • Original Article

Is the addition of a neurokinin-1 receptor antagonist beneficial in moderately emetogenic chemotherapy?—a systematic review and meta-analysis

  • Review Article

Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study

  • Original Article

The value of physical performance measurements alongside assessment of sarcopenia in predicting receipt and completion of planned treatment in non-small cell lung cancer: an observational exploratory study

  • Original Article

Neu im Fachgebiet Onkologie

Polypen bei nahen Verwandten – erhöhtes Darmkrebsrisiko

Werden bei erstgradigen Verwandten gutartige Darmpolypen identifiziert, ist das Risiko, selbst an einem Kolorektalkarzinom zu erkranken, deutlich erhöht – vor allem das für eine früh beginnende Erkrankung. Hier könnte sich eine frühe Koloskopie besonders lohnen.

KI-gestütztes Mammografiescreening überzeugt im Praxistest

Mit dem Einsatz künstlicher Intelligenz lässt sich die Detektionsrate im Mammografiescreening offenbar deutlich steigern. Mehr unnötige Zusatzuntersuchungen sind laut der Studie aus Deutschland nicht zu befürchten.

Welche Krebserkrankungen bei Zöliakie häufiger auftreten

Eine große Kohortenstudie hat den Zusammenhang zwischen Zöliakie und gastrointestinalen Krebserkrankungen und inflammatorischen Krankheiten untersucht. Neben gastrointestinalen Tumoren ist auch ein nicht solider Krebs häufiger.

Adjuvanter PD-L1-Hemmer verhindert Rezidive bei Hochrisiko-Urothelkarzinom

Sind Menschen mit muskelinvasivem Urothelkarzinom für die neoadjuvante platinbasierte Therapie nicht geeignet oder sprechen sie darauf nicht gut an, ist Pembrolizumab eine adjuvante Alternative: Die krankheitsfreie Lebenszeit wird dadurch mehr als verdoppelt.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise