Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Obesity Surgery
Erschienen in: Obesity Surgery 10/2021

09.08.2021 | Review

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

verfasst von: Sapana R. Gupta, Yingjie Zhou, Thomas A. Wadden, Robert I. Berkowitz, Ariana M. Chao

Erschienen in: Obesity Surgery | Ausgabe 10/2021

Einloggen, um Zugang zu erhalten

Abstract

This systematic review synthesized research evaluating the relationship between genetic predictors and weight loss after bariatric surgery. Fifty-seven studies were identified that examined single genes or genetic risk scores. Uncoupling protein (UCP) rs660339 was associated with excess weight loss after surgery in 4 of 6 studies. The most commonly assessed genes were fat mass and obesity–associated (FTO) gene (n = 10) and melanocortin-4 receptor (MC4R) (n = 14). Both were inconsistently related to weight loss. Genetic risk scores predicted weight loss in 6 of 7 studies. This evidence suggests the potential of using genetic variants and genetic risk scores to predict the amount of weight loss anticipated after bariatric surgery and identify patients who may be at risk for suboptimal weight reduction.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Chang S-H, Stoll CR, Song J, et al. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012. JAMA Surg. 2014;149(3):275–87.PubMedPubMedCentralCrossRef
2.
Courcoulas AP, King WC, Belle SH, et al. Seven-year weight trajectories and health outcomes in the Longitudinal Assessment of Bariatric Surgery (LABS) study. JAMA Surg. 2018;153(5):427–34.PubMedCrossRef
3.
Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52.PubMedCrossRef
4.
Karlsson J, Taft C, Ryden A, et al. Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study. Int J Obes. 2007;31(8):1248–61.CrossRef
5.
Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27(4):325–51.PubMedCrossRef
6.
Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889–94.PubMedPubMedCentralCrossRef
7.
Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197–206.PubMedPubMedCentralCrossRef
8.
9.
Bayer S, Winkler V, Hauner H, et al. Associations between genotype–diet interactions and weight loss—a systematic review. Nutrients. 2020;12(9):2891.PubMedCentralCrossRef
10.
Xiang L, Wu H, Pan A, et al. FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis. Am J Clin Nutr. 2016;103(4):1162–70.PubMedPubMedCentralCrossRef
11.
Martínez JA, Milagro FI. Genetics of weight loss: a basis for personalized obesity management. Trends Food Sci Technol. 2015;42(2):97–115.CrossRef
12.
Goodarzi MO. Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol. 2018;6(3):223–36.PubMedCrossRef
13.
Page MJ, McKenzie JE, Bossuyt PM, et al. Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement. J Clin Epidemiol. 2021;134:103–12.PubMedCrossRef
14.
Sohani ZN, Meyre D, de Souza RJ, et al. Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool. BMC Genet. 2015;16(1):1–8.CrossRef
15.
Bandstein M, Schultes B, Ernst B, et al. The role of FTO and vitamin D for the weight loss effect of Roux-en-Y gastric bypass surgery in obese patients. Obes Surg. 2015;25(11):2071–7.PubMedPubMedCentralCrossRef
16.
Liou T-H, Chen H-H, Wang W, et al. ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients. Obes Surg. 2011;21(11):1758–65.PubMedCrossRef
17.
de Luis DA, Aller R, Conde R, et al. Effects of RS9939609 gene variant in FTO gene on weight loss and cardiovascular risk factors after biliopancreatic diversion surgery. J Gastrointest Surg. 2012;16(6):1194–8.PubMedCrossRef
18.
Rodrigues GK, Resende CM, Durso DF, et al. A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery. Nutrition. 2015;31(11-12):1344–50.PubMedCrossRef
19.
Sarzynski M, Jacobson P, Rankinen T, et al. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes. 2011;35(5):676–83.CrossRef
20.
Figueroa-Vega N, Jordán B, Pérez-Luque EL, et al. Effects of sleeve gastrectomy and rs9930506 FTO variants on angiopoietin/Tie-2 system in fat expansion and M1 macrophages recruitment in morbidly obese subjects. Endocrine. 2016;54(3):700–13.PubMedCrossRef
21.
Javanrouh N, Khalaj A, Guity K, et al. Presence of CC genotype for rs17773430 could affect the percentage of excess weight loss 1 year after bariatric surgery: Tehran Obesity Treatment Study (TOTS). Obes Surg. 2020;30(2):537–44.PubMedCrossRef
22.
Mirshahi UL, Still CD, Masker KK, et al. The MC4R (I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery. J Clin Endocrinol Metab. 2011;96(12):E2088–96.PubMedPubMedCentralCrossRef
23.
Kops NL, Vivan MA, Horvath JD, et al. FABP2, LEPR223, LEP656, and FTO polymorphisms: effect on weight loss 2 years after bariatric surgery. Obes Surg. 2018;28(9):2705–11.PubMedCrossRef
24.
De Luis DA, Aller R, Sagrado MG, et al. Influence of Lys656asn polymorphism of leptin receptor gene on surgical results of biliopancreatic diversion. J Gastrointest Surg. 2010;14(5):899–903.PubMedCrossRef
25.
Chen H-H, Lee W-J, Wang W, et al. Ala55Val polymorphism on UCP2 gene predicts greater weight loss in morbidly obese patients undergoing gastric banding. Obes Surg. 2007;17(7):926–33.PubMedCrossRef
26.
Lee YC, Liew P-L, Lee W-J, et al. Prediction of successful weight reduction after laparoscopic adjustable gastric banding. Hepatogastroenterology. 2009;56(93):1222–6.PubMed
27.
Nicoletti CF, de Oliveira APR, Brochado MJF, et al. The Ala55Val and-866G> A polymorphisms of the UCP2 gene could be biomarkers for weight loss in patients who had Roux-en-Y gastric bypass. Nutrition. 2017;33:326–30.PubMedCrossRef
28.
Sesti G, Perego L, Cardellini M, et al. Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet. J Clin Endocrinol Metab. 2005;90(9):5064–9.PubMedCrossRef
29.
Di Renzo L, Carbonelli MG, Bianchi A, et al. Impact of the− 174 G> C IL-6 polymorphism on bioelectrical parameters in obese subjects after laparoscopic adjustable gastric banding. J Obes. 2012;2012:1–7.CrossRef
30.
Di Renzo L, Carbonelli M, Bianchi A, et al. Body composition changes after laparoscopic adjustable gastric banding: what is the role of− 174G> C interleukin-6 promoter gene polymorphism in the therapeutic strategy? Int J Obes. 2012;36(3):369–78.CrossRef
31.
Vitolo E, Santini E, Seghieri M, et al. Heterozygosity for the rs696217 SNP in the preproghrelin gene predicts weight loss after bariatric surgery in severely obese individuals. Obes Surg. 2017;27(4):961–7.PubMedCrossRef
32.
Matzko ME, Argyropoulos G, Wood GC, et al. Association of ghrelin receptor promoter polymorphisms with weight loss following Roux-en-Y gastric bypass surgery. Obes Surg. 2012;22(5):783–90.PubMedPubMedCentralCrossRef
33.
Velázquez-Fernández D, Mercado-Celis G, Flores-Morales J, et al. Analysis of gene candidate SNP and ancestral origin associated to obesity and postoperative weight loss in a cohort of obese patients undergoing RYGB. Obes Surg. 2017;27(6):1481–92.PubMedCrossRef
34.
Hartmann IB, Fries GR, Bücker J, et al. The FKBP5 polymorphism rs1360780 is associated with lower weight loss after bariatric surgery: 26 months of follow-up. Surg Obes Relat Dis. 2016;12(8):1554–60.PubMedCrossRef
35.
Peña E, Caixàs A, Arenas C, et al. Role of the FKBP5 polymorphism rs1360780, age, sex, and type of surgery in weight loss after bariatric surgery: a follow-up study. Surg Obes Relat Dis. 2020;16(4):581–9.PubMedCrossRef
36.
Rinella ES, Still C, Shao Y, et al. Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2013;98(6):E1131–6.PubMedPubMedCentralCrossRef
37.
Ciudin A, Fidilio E, Ortiz A, et al. Genetic testing to predict weight loss and diabetes remission and long-term sustainability after bariatric surgery: a pilot study. J Clin Med. 2019;8(7):964.PubMedCentralCrossRef
38.
de Toro-Martin J, Guenard F, Tchernof A, et al. Polygenic risk score for predicting weight loss after bariatric surgery. JCI Insight. 2018;6:3(17).
39.
Aasbrenn M, Schnurr TM, Have CT, et al. Genetic determinants of weight loss after bariatric surgery. Obes Surg. 2019;29(8):2554–61.PubMedCrossRef
40.
Katsareli E, Amerikanou C, Rouskas K, et al. A genetic risk score for the estimation of weight loss after bariatric surgery. Obes Surg. 2020;30(4):1482–90.PubMedCrossRef
41.
Nicoletti CF, Pinhel MAS, de Oliveira BAP, et al. The genetic predisposition score of seven obesity-related single nucleotide polymorphisms is associated with better metabolic outcomes after Roux-en-Y gastric bypass. J Nutrigenet Nutrigenomics. 2016;9(5-6):222–30.PubMed
42.
Käkelä P, Jääskeläinen T, Torpström J, et al. Genetic risk score does not predict the outcome of obesity surgery. Obes Surg. 2014;24(1):128–33.PubMedCrossRef
43.
Scott F, Elahi S, Adebibe M, et al. Farnesoid X receptor-a molecular predictor of weight loss after vertical sleeve gastrectomy? Obes Sci Pract. 2019;5(3):273–80.PubMedPubMedCentralCrossRef
44.
Balasar Ö, Çakır T, Erkal Ö, et al. The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy. Surg Endosc. 2016;30(1):121–5.PubMedCrossRef
45.
Novais PFS, Weber TK, Lemke N, et al. Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women. Obes Res Clin Pract. 2016;10(6):724–7.PubMedCrossRef
46.
Wang C-Y, Liu K-H, Tsai M-L, et al. FTO variants are associated with ANGPTL4 abundances and correlated with body weight reduction after bariatric surgery. Obes Res Clin Pract. 2020;14(3):257–63.PubMedCrossRef
47.
Cooiman M, Kleinendorst L, Aarts E, et al. Genetic obesity and bariatric surgery outcome in 1014 patients with morbid obesity. Obes Surg. 2020;30(2):470–7.PubMedCrossRef
48.
Potoczna N, Branson R, Kral JG, et al. Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity. J Gastrointest Surg. 2004;8(8):971–82.PubMedCrossRef
49.
Resende CMM, Durso DF, Borges KBG, et al. The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months. Clin Nutr. 2018;37(4):1286–92.PubMedCrossRef
50.
Aslan IR, Campos GM, Calton MA, et al. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg. 2011;21(7):930–4.PubMedCrossRef
51.
Censani M, Conroy R, Deng L, et al. Weight loss after bariatric surgery in morbidly obese adolescents with MC4R mutations. Obesity (Silver Spring). 2014;22(1):225–31.CrossRef
52.
Hatoum IJ, Stylopoulos N, Vanhoose AM, et al. Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery. J Clin Endocrinol Metab. 2012;97(6):E1023–31.PubMedPubMedCentralCrossRef
53.
Moore BS, Mirshahi UL, Yost EA, et al. Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants. PLoS One. 2014;9(4):e93629.PubMedPubMedCentralCrossRef
54.
Valette M, Poitou C, Le Beyec J, et al. Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. PLoS One. 2012;7(11):e48221.PubMedPubMedCentralCrossRef
55.
Zechner JF, Mirshahi UL, Satapati S, et al. Weight-independent effects of roux-en-Y gastric bypass on glucose homeostasis via melanocortin-4 receptors in mice and humans. Gastroenterology. 2013;144(3):580–590. e587.PubMedCrossRef
56.
De Luis D, Pacheco D, Aller R, et al. Influence of-55CT polymorphism of UCP3 gene on surgical results of biliopancreatic diversion. Obes Surg. 2010;20(7):895–9.PubMedCrossRef
57.
de Luis DA, Sagrado MG, Izaola O, et al. Influence of Ala54Thr polymorphism of fatty acid–binding protein-2 on clinical results of biliopancreatic diversion. Nutrition. 2008;24(4):300–4.PubMedCrossRef
58.
Hulsmans M, Geeraert B, De Keyzer D, et al. Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome. PLoS One. 2012;7(1):e30414.PubMedPubMedCentralCrossRef
59.
De Luis D, Pacheco D, Aller R, et al. Influence of G308A polymorphism of tumor necrosis factor alpha gene on surgical results of biliopancreatic diversion. Obes Surg. 2010;20(2):221–5.PubMedCrossRef
60.
Alexandrou A, Armeni E, Kaparos G, et al. Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery. J Investig Surg. 2015;28(1):8–17.CrossRef
61.
Hatoum IJ, Greenawalt DM, Cotsapas C, et al. Weight loss after gastric bypass is associated with a variant at 15q26. 1. Am J Hum Genet. 2013;92(5):827–34.PubMedPubMedCentralCrossRef
62.
Beisani M, Pappa S, Moreno P, et al. Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells. Clin Nutr. 2020;39(2):592–8.PubMedCrossRef
63.
Poitou C, Lacorte J-M, Coupaye M, et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg. 2005;15(1):11–23.PubMedCrossRef
64.
Rasmussen-Torvik LJ, Baldridge AS, Pacheco JA, et al. rs4771122 predicts multiple measures of long-term weight loss after bariatric surgery. Obes Surg. 2015;25(11):2225–9.PubMedPubMedCentralCrossRef
65.
Bandstein M, Mwinyi J, Ernst B, et al. A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery. Scand J Gastroenterol. 2016;51(9):1050–5.PubMedPubMedCentralCrossRef
66.
De Luis D, Sagrado MG, Pacheco D, et al. Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss and cardiovascular risk factors 1 year after biliopancreatic diversion surgery. Surg Obes Relat Dis. 2010;6(5):516–20.PubMedCrossRef
67.
Leyvraz C, Verdumo C, Suter M, et al. Changes in gene expression profile in human subcutaneous adipose tissue during significant weight loss. Obes Facts. 2012;5(3):440–51.PubMedCrossRef
68.
Ruiz-Lozano T, Vidal J, De Hollanda A, et al. Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C. Int J Obes. 2016;40(10):1550–7.CrossRef
69.
Potoczna N, Wertli M, Steffen R, et al. G protein polymorphisms do not predict weight loss and improvement of hypertension in severely obese patients. J Gastrointest Surg. 2004;8(7):862–8.PubMedCrossRef
70.
Goergen M, Manzoni D, De Blasi V, et al. Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass. Bull Soc Sci Med Grand Duche Luxemb. 2011;2:7–24.
71.
de Luis D, Calvo SG, Primo D, et al. Polymorphism rs3123554 in the cannabinoid receptor type 2 (CB2R) gene is associated with metabolic changes after biliopancreatic diversion surgery. Endocrinol Diabetes Nutr (Engl Ed). 2019;66(3):157–63.
72.
Scuteri A, Sanna S, Chen W-M, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3(7):e115.PubMedPubMedCentralCrossRef
73.
Alalwan AA, Friedman J, Park H, et al. US national trends in bariatric surgery: a decade of study. Surgery. 2021;170:13–7.PubMedCrossRef
Metadaten
Titel
A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery
verfasst von
Sapana R. Gupta
Yingjie Zhou
Thomas A. Wadden
Robert I. Berkowitz
Ariana M. Chao
Publikationsdatum
09.08.2021
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 10/2021
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-021-05585-6

Weitere Artikel der Ausgabe 10/2021

Obesity Surgery 10/2021 Zur Ausgabe

Original Contributions

Factors Affecting Patient Adherence to Multivitamin Intake After Bariatric Surgery: a Multicentre Survey Study from the Patient’s Perspective

Brief Communication

Screening and treatment of thiamine deficiency in a sample of multidisciplinary bariatric surgery clinical teams

Original Contributions

Network Meta-Analysis of Metabolic Surgery Procedures for the Treatment of Obesity and Diabetes

Original Contributions

Comparison of Bioelectrical Impedance Analysis and Computed Tomography on Body Composition Changes Including Visceral Fat After Bariatric Surgery in Asian Patients with Obesity

Letter to the Editor

Non-operative Management of Obstructing Clot at the Jejunojejunal Anastomosis Site After Laparoscopic Roux-en-Y Gastric Bypass: a Case Report

Review

Are the Changes in Gastrointestinal Hormone Secretion Necessary for the Success of Bariatric Surgery? A Critical Review of the Literature

Neu im Fachgebiet Chirurgie

17.04.2024 | Postoperative nausea and vomiting | Nachrichten

Hochrisiko-Eingriffe für postoperative Übelkeit

16.04.2024 | HNO-Chirurgie | Nachrichten

HNO-Op. auch mit über 90?

16.04.2024 | Infektiologie | Nachrichten

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

10.04.2024 | Postoperative Schmerztherapie | Nachrichten

Chronische Schmerzen nach Op. oft mit neuropathischer Komponente
weitere anzeigen

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom CME-Kurs
CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur CME-Kurs
CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis CME-Kurs
CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.