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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Women's Health 1/2018

A systematic review of methods to measure menstrual blood loss

BMC Women's Health > Ausgabe 1/2018
Julia L. Magnay, Shaughn O’Brien, Christoph Gerlinger, Christian Seitz
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12905-018-0627-8) contains supplementary material, which is available to authorized users.



Since the publication over 50 years ago of the alkaline hematin method for quantifying menstrual blood loss (MBL) many new approaches have been developed to assess MBL. The aim of this systematic review is to determine for methods of measuring MBL: ability to distinguish between normal and heavy menstrual bleeding (HMB); practicalities and limitations in the research setting; and suitability for diagnosing HMB in routine clinical practice.


Embase®™, MEDLINE®, and ClinicalTrials.​gov were screened for studies on the development/validation of MBL assessment methods in women with self-perceived HMB, actual HMB or uterine fibroids, or patients undergoing treatment for HMB. Studies using simulated menstrual fluid and those that included women with normal MBL as controls were also eligible for inclusion. Extracted data included study population, results of validation, and advantages/disadvantages of the technique.


Seventy-one studies fulfilled the inclusion criteria. The sensitivity and/or specificity of diagnosing HMB were calculated in 16 studies of methods involving self-perception of MBL (11 pictorial), and in one analysis of the menstrual-fluid-loss (MFL) method; in 13 of these studies the comparator was the gold standard alkaline hematin technique. Sensitivity and specificity values by method were, respectively: MFL model, 89, 98%; pictorial blood loss assessment chart (PBAC), 58–99%, 7.5–89%; menstrual pictogram, 82–96%, 88–94%; models/questionnaires, 59–87%, 62–86%, and complaint of HMB, 74, 74%. The power of methods to identify HMB was also assessed using other analyses such as comparison of average measurements: statistical significance was reported for the PBAC, MFL, subjective complaint, and six questionnaires. In addition, PBAC scores, menstrual pictogram volumes, MFL, pad/tampon count, iron loss, and output from three questionnaires correlated significantly with values from a reference method in at least one study. In general, pictorial methods have been more comprehensively validated than questionnaires and models.


Every method to assess MBL has limitations. Pictorial methods strike a good balance between ease of use and validated accuracy of MBL determination, and could complement assessment of HMB using quality of life (QoL) in the clinical and research setting.

Trial registration

PRISMA registration number: CRD42016032956.
Additional file 1: Table S1. Full electronic search strategy of Embase®™ and Medline. (PDF 44 kb)
Additional file 3: Table S3. Overview of types of validation performed, practicalities, and limitations of methods. (PDF 232 kb)
Additional file 4: Table S4. Further validation of methods. (PDF 171 kb)
Additional file 5: Table S5. Correlations of methods with established standards. (PDF 168 kb)
Additional file 6: Table S6. Assessment of discriminatory power of methods for assessing MBL. (PDF 148 kb)
Additional file 7: Completed PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) checklist. (PDF 133 kb)
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