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10.03.2021 | Brief Report

A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis

verfasst von: Taro Murakami, Akira Takasawa, Asako Moriki, Yusuke Igaki, Hiroshi Ikeda, Kazuyuki Murase, Kohichi Takada, Kazufumi Magara, Tomoyuki Aoyama, Yusuke Ono, Daisuke Kyuno, Kumi Takasawa, Masaki Murata, Makoto Osanai

Erschienen in: Virchows Archiv | Ausgabe 5/2021

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Abstract

Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans. Although it is very important to determine the specific amyloid protein type for the choice of therapy for amyloidosis patient, it might be difficult to identify specific proteins from amyloid-deposited tissue. Apolipoprotein A-IV is known as an amyloid-associated protein, but there have been few reports of apolipoprotein A-IV amyloidosis. Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.

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Titel: A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis
verfasst von: Taro Murakami
Akira Takasawa
Asako Moriki
Yusuke Igaki
Hiroshi Ikeda
Kazuyuki Murase
Kohichi Takada
Kazufumi Magara
Tomoyuki Aoyama
Yusuke Ono
Daisuke Kyuno
Kumi Takasawa
Masaki Murata
Makoto Osanai
Publikationsdatum: 10.03.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 5/2021
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-021-03073-x

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis

Abstract

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Abstract

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