A previously healthy 18-year-old man presented with malaise, fever, and rash for 5 days. His only recent medication was amoxicillin for otitis media 2 weeks before symptom onset. Examination revealed conjunctival hyperemia, polymorphous rash, and labial, oral, and nasal mucositis (Figs. 1 and 2). Laboratory testing and a chest radiograph were unremarkable. Bacterial blood cultures, HIV testing, Mycoplasma pneumonia testing, and PCR for herpes simplex virus were negative. He was diagnosed with Stevens-Johnson syndrome (SJS) due to amoxicillin and his symptoms resolved after 3 weeks.
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