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Erschienen in: Heart and Vessels 8/2016

02.08.2015 | Original Article

Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome

verfasst von: Atsushi Sakamoto, Masao Saotome, Natsuko Hosoya, Shigetaka Kageyama, Toru Yoshizaki, Ryosuke Takeuchi, Koichiro Murata, Ryuzo Nawada, Tomoya Onodera, Akinori Takizawa, Hiroshi Satoh, Hideharu Hayashi

Erschienen in: Heart and Vessels | Ausgabe 8/2016

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Abstract

Although a robust relationship between aberrant serum polyunsaturated fatty acids (PUFAs) profile and coronary artery disease (CAD) has been reported, the details concerning the association between aberrant PUFAs profile and clinical feature of CAD are not fully discovered. Therefore, we investigated the relationship between serum PUFAs and clinical profiles in CAD patients. We classified 595 consecutive CAD patients, who underwent coronary angiography into 3 groups according to the clinical profiles of CAD (group A: early phase ACS, n = 96; group B: stable CAD with previous history of ACS, n = 259; group C: stable CAD without previous history of ACS, n = 240) and measured serum n-3 [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and n-6 [arachidonic acid (AA)] PUFAs. Serum EPA, DHA, and EPA/AA ratio were significantly low in the order of group A < B < C [EPA; 48.1 (34.1–60.3) μg/ml, 61.7 (41.2–94.5) μg/ml, and 74.4 (52.7–104.9) μg/ml, DHA; 113.1 (92.8–135.1) μg/ml, 125.8 (100.4–167.2) μg/ml, and 140.1 (114.7–177.0) μg/ml, EPA/AA ratio; 0.31 (0.22–0.45), 0.39 (0.26–0.62), and 0.44 (0.31–0.69), medians with interquartile range, p < 0.01]. Multiple regression analysis revealed that EPA (p = 0.009) and EPA/AA ratio (p = 0.023), but not DHA and DHA/AA ratio, were negatively associated with clinical profiles of ACS in CAD patients. Significant correlation was not observed between PUFAs profile and severity of coronary stenosis. Low serum EPA and EPA/AA ratio correlates with clinical profiles of ACS in patients with CAD, regardless of the extent and severity of coronary artery stenosis.
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Metadaten
Titel
Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome
verfasst von
Atsushi Sakamoto
Masao Saotome
Natsuko Hosoya
Shigetaka Kageyama
Toru Yoshizaki
Ryosuke Takeuchi
Koichiro Murata
Ryuzo Nawada
Tomoya Onodera
Akinori Takizawa
Hiroshi Satoh
Hideharu Hayashi
Publikationsdatum
02.08.2015
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 8/2016
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-015-0721-x

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