Skip to main content
Erschienen in: Journal of Cancer Research and Clinical Oncology 5/2018

27.02.2018 | Original Article – Clinical Oncology

Ablative dual-phase Erbium:YAG laser treatment of atrophy-related vaginal symptoms in post-menopausal breast cancer survivors omitting hormonal treatment

verfasst von: A. R. Mothes, M. Runnebaum, I. B. Runnebaum

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

First evaluation of dual-phase vaginal Er:YAG laser to omit hormonal treatment for atrophy-related symptoms in post-menopausal breast cancer survivors following prolapse surgery.

Methods

Patients with a history of breast cancer at the time of surgery for pelvic organ prolapse were offered non-hormonal vaginal Er:YAG laser treatment when complaining of atrophy-related genitourinary syndrome of menopause. A single 10-min course of dual-phase protocol of pulsed Er:YAG laser (2940 nm, fractional ablative and thermal mode, fluence according to tissue thickness). Follow-up included subjective satisfaction, vaginal pH, vaginal health index (VHI), and complications after 6 weeks.

Results

A total of 16 breast cancer survivors (age 71 years, SD 7) had been seeking treatment for pelvic floor symptoms related to vaginal atrophy at follow-up visits after prolapse surgery. All ablative vaginal Er:YAG laser outpatient procedures were successfully completed, all patients returned to daily activities without a need for analgetic medication. Evaluation was performed after 8.3 (SD 2.5) weeks. Pre-laser VHI scored 16 (SD 4.6) and post-laser VHI 20 (SD 3) with p = 0.01. Patients were satisfied in 94% (n = 15) regarding symptom relief.

Conclusions

Breast cancer survivors with atrophy-related complaints after pelvic floor surgery may benefit from vaginal application of this innovative dual protocol of Er:YAG laser technology as a non-hormonal treatment approach.
Literatur
Zurück zum Zitat Alexiades-Armenakas MR, Dover JS, Arndt KA (2012) Fractional laser skin resurfacing. J Drugs Dermatol 11:1274–1287PubMed Alexiades-Armenakas MR, Dover JS, Arndt KA (2012) Fractional laser skin resurfacing. J Drugs Dermatol 11:1274–1287PubMed
Zurück zum Zitat Bachman GA, Noeyolitz M, Kelly SL (1992) Long-term non-hormonal treatment of vaginal dryness. Clin Pract Sex 8:3–8 Bachman GA, Noeyolitz M, Kelly SL (1992) Long-term non-hormonal treatment of vaginal dryness. Clin Pract Sex 8:3–8
Zurück zum Zitat Brubaker L, Shull B (2005) EGGS for patient-centered outcomes. Int Urogynecol J Pelvic Floor Dysfunct 16:171–173CrossRefPubMed Brubaker L, Shull B (2005) EGGS for patient-centered outcomes. Int Urogynecol J Pelvic Floor Dysfunct 16:171–173CrossRefPubMed
Zurück zum Zitat Bump RC, Mattiasson A, Bo K, Brubaker LP, DeLancey JO, Klarskov P et al (1996) The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 175:10–17CrossRefPubMed Bump RC, Mattiasson A, Bo K, Brubaker LP, DeLancey JO, Klarskov P et al (1996) The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 175:10–17CrossRefPubMed
Zurück zum Zitat Dmovsek-Olup B, Beltram M, Pizern J (2004) Repetitive Er:YAG laser irritation of human skin: a histological evaluation. Lasers Surg Med 35:146–151CrossRef Dmovsek-Olup B, Beltram M, Pizern J (2004) Repetitive Er:YAG laser irritation of human skin: a histological evaluation. Lasers Surg Med 35:146–151CrossRef
Zurück zum Zitat Donders G, Neven P, Moegele M, Lintermans A, Bellen G, Prasauskas V, Grob P, Ortmann O, Buchholz S (2014) Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor(®)) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study. Breast Cancer Res Treat 145:371–379. https://doi.org/10.1007/s10549-014-2930-x CrossRefPubMedPubMedCentral Donders G, Neven P, Moegele M, Lintermans A, Bellen G, Prasauskas V, Grob P, Ortmann O, Buchholz S (2014) Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor(®)) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study. Breast Cancer Res Treat 145:371–379. https://​doi.​org/​10.​1007/​s10549-014-2930-x CrossRefPubMedPubMedCentral
Zurück zum Zitat Fisher JC (1992) Photons, physiatrics, and physicians: A practical guide to understanding laser light interaction with living tissue, part 1. J Clin Laser Med Surg 10:419–426PubMed Fisher JC (1992) Photons, physiatrics, and physicians: A practical guide to understanding laser light interaction with living tissue, part 1. J Clin Laser Med Surg 10:419–426PubMed
Zurück zum Zitat Majaron B, Srinivas SM, Huang HE, Nelson JS (2000) Deep coagulation of dermal collagen with repetetive Er:YAG laser irritation. Lasers Surg Med 26:215–222CrossRefPubMed Majaron B, Srinivas SM, Huang HE, Nelson JS (2000) Deep coagulation of dermal collagen with repetetive Er:YAG laser irritation. Lasers Surg Med 26:215–222CrossRefPubMed
Zurück zum Zitat Portman DJ, Gass ML, Vulvovaginal Atrophy Terminology Consensus Conference Panel (2014) Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and The North American Menopause Society. Climacteric 17:557–563. https://doi.org/10.3109/13697137.2014.946279 CrossRef Portman DJ, Gass ML, Vulvovaginal Atrophy Terminology Consensus Conference Panel (2014) Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and The North American Menopause Society. Climacteric 17:557–563. https://​doi.​org/​10.​3109/​13697137.​2014.​946279 CrossRef
Zurück zum Zitat Schmitt L, Amann PM, Marquardt Y, Heise R, Czaja K, Gerber PA, Steiner T, Hölzle F, Baron JM (2017) Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models. Lasers Med Sci 32:805–814. https://doi.org/10.1007/s10103-017-2175-0 CrossRefPubMed Schmitt L, Amann PM, Marquardt Y, Heise R, Czaja K, Gerber PA, Steiner T, Hölzle F, Baron JM (2017) Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models. Lasers Med Sci 32:805–814. https://​doi.​org/​10.​1007/​s10103-017-2175-0 CrossRefPubMed
Zurück zum Zitat Tadir Y, Gaspar A, Lev-Sagie A, Alexiades M, Alinsod R, Bader A, Calligaro A, Elias JA, Gambaciani M, Gaviria JE, Iglesia CB, Selih-Martinec K, Mwesigwa PL, Ogrinc UB, Salvatore S, Scollo P, Zerbinati N, Nelson JS (2017) Light and energy based therapeutics for genitourinary syndrome of menopause: consensus and controversies. Lasers Surg Med 49:137–159. https://doi.org/10.1002/lsm.22637 CrossRefPubMedPubMedCentral Tadir Y, Gaspar A, Lev-Sagie A, Alexiades M, Alinsod R, Bader A, Calligaro A, Elias JA, Gambaciani M, Gaviria JE, Iglesia CB, Selih-Martinec K, Mwesigwa PL, Ogrinc UB, Salvatore S, Scollo P, Zerbinati N, Nelson JS (2017) Light and energy based therapeutics for genitourinary syndrome of menopause: consensus and controversies. Lasers Surg Med 49:137–159. https://​doi.​org/​10.​1002/​lsm.​22637 CrossRefPubMedPubMedCentral
Metadaten
Titel
Ablative dual-phase Erbium:YAG laser treatment of atrophy-related vaginal symptoms in post-menopausal breast cancer survivors omitting hormonal treatment
verfasst von
A. R. Mothes
M. Runnebaum
I. B. Runnebaum
Publikationsdatum
27.02.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 5/2018
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-018-2614-8

Weitere Artikel der Ausgabe 5/2018

Journal of Cancer Research and Clinical Oncology 5/2018 Zur Ausgabe

Original Article – Clinical Oncology

Management of elderly women with cervical cancer

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.