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Brain Topography

Erschienen in:

30.01.2016 | Original Paper

Abnormal Functional Connectivity Density in Post-traumatic Stress Disorder

verfasst von: Youxue Zhang, Bing Xie, Heng Chen, Meiling Li, Feng Liu, Huafu Chen

Erschienen in: Brain Topography | Ausgabe 3/2016

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Abstract

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that occurs in individuals who have experienced life-threatening mental traumas. Previous neuroimaging studies have indicated that the pathology of PTSD may be associated with the abnormal functional integration among brain regions. In the current study, we used functional connectivity density (FCD) mapping, a novel voxel-wise data-driven approach based on graph theory, to explore aberrant FC through the resting-state functional magnetic resonance imaging of the PTSD. We calculated both short- and long-range FCD in PTSD patients and healthy controls (HCs). Compared with HCs, PTSD patients showed significantly increased long-range FCD in the left dorsolateral prefrontal cortex (DLPFC), but no abnormal short-range FCD was found in PTSD. Furthermore, seed-based FC analysis of the left DLPFC showed increased connectivity in the left superior parietal lobe and visual cortex of PTSD patients. The results suggested that PTSD patients experienced a disruption of intrinsic long-range functional connections in the fronto-parietal network and visual cortex, which are associated with attention control and visual information processing.

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Titel: Abnormal Functional Connectivity Density in Post-traumatic Stress Disorder
verfasst von: Youxue Zhang
Bing Xie
Heng Chen
Meiling Li
Feng Liu
Huafu Chen
Publikationsdatum: 30.01.2016
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 3/2016
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-016-0472-8

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