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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 1/2018

25.11.2017 | Review

Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance

verfasst von: Graziella Privitera, Luisa Spadaro, Simona Marchisello, Giuseppe Fede, Francesco Purrello

Erschienen in: Digestive Diseases and Sciences | Ausgabe 1/2018

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Abstract

Progressive lipoprotein impairment occurs in liver cirrhosis and is associated with increased morbidity and mortality. The present review aims to summarize the current evidence regarding the prognostic value of lipoprotein abnormalities in liver cirrhosis and to address the need of a better prognostic stratification of patients, including lipoprotein profile assessment. Low levels of lipoproteins are usual in cirrhosis. Much evidence supports the prognostic role of hypolipidemia in cirrhotic patients. In particular, hypocholesterolemia represents an independent predictor of survival in cirrhosis. In cirrhotic patients, lipoprotein impairment is associated with several complications: infections, malnutrition, adrenal function, and spur cell anemia. Alterations of liver function are associated with modifications of circulating lipids. Decreased levels of lipoproteins significantly impact the survival of cirrhotic patients and play an important role in the pathogenesis of some cirrhosis-related complications.
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Metadaten
Titel
Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance
verfasst von
Graziella Privitera
Luisa Spadaro
Simona Marchisello
Giuseppe Fede
Francesco Purrello
Publikationsdatum
25.11.2017
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 1/2018
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4862-x

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