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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2005

01.04.2005 | Laboratory Investigation

Accuracy of dynamic contour tonometry compared with applanation tonometry in human cadaver eyes of different hydration states

verfasst von: Christoph Kniestedt, Michelle Nee, Robert L. Stamper

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 4/2005

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Abstract

Background

In an experimental laboratory investigation we compared intraocular pressure (IOP) measurements obtained by dynamic contour tonometry (DCT), Goldmann applanation tonometry (GAT), and pneumatonometry (PTG) with intracameral manometry on human cadaver corneas of different hydration conditions.

Methods

Ten freshly enucleated eyes were de-epithelialized. Two tubes were placed in the anterior chamber in opposite directions and connected to a transducer and to a bottle system filled with balanced salt solution. The pressure in the eye was then adjusted between 5 mmHg and 58 mmHg by electronically altering the height of the bottle. Central corneal thickness (CCT) was registered and IOP measurements were obtained with DCT, GAT, and PTG at each manometric pressure reading. Immediately after the trial the same corneas were artificially dehydrated and the same measurement regimen was repeated.

Results

In the pressure range defined by the bottle height 10–50 cm, IOP values measured by DCT were 0.50 mmHg (95% CI=0.40–0.60) and 0.36 mmHg (95% CI=0.25–0.47) higher than manometric readings before and after dehydration, respectively. GAT showed consistently lower values than manometry, the difference being −3.48 mmHg (95% CI=−3.91 to −3.05) and −3.14 mmHg (95% CI=−3.39 to −2.89), respectively. Similar results were obtained with PGT, namely differences of −4.75 mmHg (95% CI=−5.21 to −4.29) and −3.98 mmHg (95% CI=−4.48 to −3.48) for the hydrated and the dehydrated corneal condition, respectively. Only DCT showed no significant change in accuracy between hydrated and dehydrated corneas.

Conclusions

In this in vitro study DCT values for IOP were significantly closer to the manometric reference pressure than those obtained using GAT and PTG, independent of the state of corneal hydration.
Literatur
1.
Zurück zum Zitat Brandt JD, Beiser JA, Kass MA, Gordon MO (2001) Central corneal thickness in the ocular hypertension treatment study (OHTS). Ophthalmology 108:1779–1788CrossRefPubMed Brandt JD, Beiser JA, Kass MA, Gordon MO (2001) Central corneal thickness in the ocular hypertension treatment study (OHTS). Ophthalmology 108:1779–1788CrossRefPubMed
2.
Zurück zum Zitat Bron AM, Creuzot-Garcher C, Goudeau-Boutillon S, d’Athis P (1999) Falsely elevated intraocular pressure due to increased central corneal thickness. Graefes Arch Clin Exp Ophthalmol 237:220–224CrossRefPubMed Bron AM, Creuzot-Garcher C, Goudeau-Boutillon S, d’Athis P (1999) Falsely elevated intraocular pressure due to increased central corneal thickness. Graefes Arch Clin Exp Ophthalmol 237:220–224CrossRefPubMed
3.
Zurück zum Zitat Doughty MJ, Zaman ML (2000) Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 44:367–408CrossRefPubMed Doughty MJ, Zaman ML (2000) Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 44:367–408CrossRefPubMed
4.
Zurück zum Zitat Duch S, Serra A, Castanera J et al (2001) Tonometry after laser in situ keratomileusis treatment. J Glaucoma 10:261–265CrossRefPubMed Duch S, Serra A, Castanera J et al (2001) Tonometry after laser in situ keratomileusis treatment. J Glaucoma 10:261–265CrossRefPubMed
5.
Zurück zum Zitat Duffey RJ, Tchah H, Lindstrom RL (1989) Human cadaver corneal thinning for experimental refractive surgery. Refract Corneal Surg 5:41–42PubMed Duffey RJ, Tchah H, Lindstrom RL (1989) Human cadaver corneal thinning for experimental refractive surgery. Refract Corneal Surg 5:41–42PubMed
6.
Zurück zum Zitat Ehlers N, Bramsen T, Sperling S (1975) Applanation tonometry and central corneal thickness. Acta Ophthalmol (Copenh) 53:34–43 Ehlers N, Bramsen T, Sperling S (1975) Applanation tonometry and central corneal thickness. Acta Ophthalmol (Copenh) 53:34–43
7.
Zurück zum Zitat Eisenberg DL, Sherman BG, McKeown CA, Schuman JS (1998) Tonometry in adults and children. A manometric evaluation of pneumatonometry, applanation, and TonoPen in vitro and in vivo. Ophthalmology 105:1173–1181CrossRefPubMed Eisenberg DL, Sherman BG, McKeown CA, Schuman JS (1998) Tonometry in adults and children. A manometric evaluation of pneumatonometry, applanation, and TonoPen in vitro and in vivo. Ophthalmology 105:1173–1181CrossRefPubMed
8.
Zurück zum Zitat Feltgen N, Leifert D, Funk J (2001) Correlation between central corneal thickness, applanation tonometry, and direct intracameral IOP readings. Br J Ophthalmol 85:85–87CrossRefPubMed Feltgen N, Leifert D, Funk J (2001) Correlation between central corneal thickness, applanation tonometry, and direct intracameral IOP readings. Br J Ophthalmol 85:85–87CrossRefPubMed
9.
Zurück zum Zitat Goldmann H (1955) Un nouveau tonometre d’applanation. Bull Soc Ophtalmol Fr 67:474–478 Goldmann H (1955) Un nouveau tonometre d’applanation. Bull Soc Ophtalmol Fr 67:474–478
10.
Zurück zum Zitat Goldmann H, Schmidt T (1957) Ueber Applanationstonometrie. Ophthalmologica 134:221–242PubMed Goldmann H, Schmidt T (1957) Ueber Applanationstonometrie. Ophthalmologica 134:221–242PubMed
11.
Zurück zum Zitat Goldmann H, Schmidt T (1965) On applanation tonography. Ophthalmologica 150:65–75PubMed Goldmann H, Schmidt T (1965) On applanation tonography. Ophthalmologica 150:65–75PubMed
12.
Zurück zum Zitat Goldmann H, Schmidt T (1966) Studien mittels Applanationstonographie. Doc Ophthalmol 20:184–213PubMed Goldmann H, Schmidt T (1966) Studien mittels Applanationstonographie. Doc Ophthalmol 20:184–213PubMed
13.
Zurück zum Zitat Hamaoui M, Tahi H, Chapon P et al (2001) Corneal preparation of eye bank eyes for experimental surgery. Cornea 20:317–320CrossRefPubMed Hamaoui M, Tahi H, Chapon P et al (2001) Corneal preparation of eye bank eyes for experimental surgery. Cornea 20:317–320CrossRefPubMed
14.
Zurück zum Zitat Johnson M, Kass MA, Moses RA, Grodzki WJ (1978) Increased corneal thickness simulating elevated intraocular pressure. Arch Ophthalmol 96:664–665PubMed Johnson M, Kass MA, Moses RA, Grodzki WJ (1978) Increased corneal thickness simulating elevated intraocular pressure. Arch Ophthalmol 96:664–665PubMed
15.
Zurück zum Zitat Kaufmann C, Bachmann LM, Thiel MA (2003) Intraocular pressure measurements using dynamic contour tonometry after laser in situ keratomileusis. Invest Ophthalmol Vis Sci 44:3790–3794CrossRefPubMed Kaufmann C, Bachmann LM, Thiel MA (2003) Intraocular pressure measurements using dynamic contour tonometry after laser in situ keratomileusis. Invest Ophthalmol Vis Sci 44:3790–3794CrossRefPubMed
16.
Zurück zum Zitat Kniestedt C, Nee M, Stamper RL (2004) Dynamic contour tonometry. A comparative study on human cadaver eyes. Arch Ophthalmol 122:1287–1293CrossRefPubMed Kniestedt C, Nee M, Stamper RL (2004) Dynamic contour tonometry. A comparative study on human cadaver eyes. Arch Ophthalmol 122:1287–1293CrossRefPubMed
17.
Zurück zum Zitat Langham ME, McCarthy E (1968) A rapid pneumatic applanation tonometer. Comparative findings and evaluation. Arch Ophthalmol 79:389–399PubMed Langham ME, McCarthy E (1968) A rapid pneumatic applanation tonometer. Comparative findings and evaluation. Arch Ophthalmol 79:389–399PubMed
18.
Zurück zum Zitat Maloney RK (1990) Effect of corneal hydration and intraocular pressure on keratometric power after experimental radial keratotomy. Ophthalmology 97:927–933PubMed Maloney RK (1990) Effect of corneal hydration and intraocular pressure on keratometric power after experimental radial keratotomy. Ophthalmology 97:927–933PubMed
19.
Zurück zum Zitat McMillan F, Forster PK (1975) Comparison of MacKay-Marg, Goldmann and Perkins tonometers in abnormal corneas. Arch Ophthalmol 93:420–424PubMed McMillan F, Forster PK (1975) Comparison of MacKay-Marg, Goldmann and Perkins tonometers in abnormal corneas. Arch Ophthalmol 93:420–424PubMed
20.
Zurück zum Zitat Moses R (1958) The Goldmann applanation tonometer. Am J Ophthalmol 46:865–869PubMed Moses R (1958) The Goldmann applanation tonometer. Am J Ophthalmol 46:865–869PubMed
21.
Zurück zum Zitat Moses RA, Grodzki WJ (1979) The pneumatonograph. A laboratory study. Arch Ophthalmol 97:547–552PubMed Moses RA, Grodzki WJ (1979) The pneumatonograph. A laboratory study. Arch Ophthalmol 97:547–552PubMed
22.
Zurück zum Zitat Muller LJ, Pels E, Vrensen GF (2001) The specific architecture of the anterior stroma accounts for maintenance of corneal curvature. Br J Ophthalmol 85:437–443CrossRefPubMed Muller LJ, Pels E, Vrensen GF (2001) The specific architecture of the anterior stroma accounts for maintenance of corneal curvature. Br J Ophthalmol 85:437–443CrossRefPubMed
23.
Zurück zum Zitat Shah S, Chatterjee A, Mathai M et al (1999) Relationship between corneal thickness and measured intraocular pressure in a general ophthalmology clinic. Ophthalmology 106:2154–2160CrossRefPubMed Shah S, Chatterjee A, Mathai M et al (1999) Relationship between corneal thickness and measured intraocular pressure in a general ophthalmology clinic. Ophthalmology 106:2154–2160CrossRefPubMed
24.
Zurück zum Zitat Simon G, Small RH, Ren Q, Parel JM (1993) Effect of corneal hydration on Goldmann applanation tonometry and corneal topography. Refract Corneal Surg 9:110–117PubMed Simon G, Small RH, Ren Q, Parel JM (1993) Effect of corneal hydration on Goldmann applanation tonometry and corneal topography. Refract Corneal Surg 9:110–117PubMed
25.
Zurück zum Zitat Singh RP, Goldberg I, Graham SL et al (2001) Central corneal thickness, tonometry, and ocular dimensions in glaucoma and ocular hypertension. J Glaucoma 10:206–210CrossRefPubMed Singh RP, Goldberg I, Graham SL et al (2001) Central corneal thickness, tonometry, and ocular dimensions in glaucoma and ocular hypertension. J Glaucoma 10:206–210CrossRefPubMed
26.
Zurück zum Zitat Swinger CA, Kornmehl EW (1985) Dehydration of post-mortem eyes for practice and experimental surgery. Ophthalmic Surg 16:182–183PubMed Swinger CA, Kornmehl EW (1985) Dehydration of post-mortem eyes for practice and experimental surgery. Ophthalmic Surg 16:182–183PubMed
27.
Zurück zum Zitat Terry MA, Ousley PJ, Zjhra ML (1994) Hydration changes in cadaver eyes prepared for practice and experimental surgery. Arch Ophthalmol 112:538–543PubMed Terry MA, Ousley PJ, Zjhra ML (1994) Hydration changes in cadaver eyes prepared for practice and experimental surgery. Arch Ophthalmol 112:538–543PubMed
28.
Zurück zum Zitat Whitacre MM, Stein RA, Hassanein K (1993) The effect of corneal thickness on applanation tonometry. Am J Ophthalmol 115:592–596PubMed Whitacre MM, Stein RA, Hassanein K (1993) The effect of corneal thickness on applanation tonometry. Am J Ophthalmol 115:592–596PubMed
29.
Zurück zum Zitat Wolfs RC, Klaver CC, Vingerling JR et al (1997) Distribution of central corneal thickness and its association with intraocular pressure: the Rotterdam Study. Am J Ophthalmol 123:767–772PubMed Wolfs RC, Klaver CC, Vingerling JR et al (1997) Distribution of central corneal thickness and its association with intraocular pressure: the Rotterdam Study. Am J Ophthalmol 123:767–772PubMed
Metadaten
Titel
Accuracy of dynamic contour tonometry compared with applanation tonometry in human cadaver eyes of different hydration states
verfasst von
Christoph Kniestedt
Michelle Nee
Robert L. Stamper
Publikationsdatum
01.04.2005
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 4/2005
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-004-1024-6

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