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Erschienen in:

10.08.2020 | Original Article

Accuracy of histological grades from intraoperative frozen-section diagnoses of soft-tissue tumors

verfasst von: Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Kaoru Tada, Takashi Higuchi, Hirotaka Yonezawa, Sei Morinaga, Yoshihiro Araki, Yohei Asano, Hiroko Ikeda, Takayuki Nojima, Hiroyuki Tsuchiya

Erschienen in: International Journal of Clinical Oncology | Ausgabe 12/2020

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Abstract

Background

For excised tumor specimens, histological grades can differ between the biopsy diagnosis and the final diagnosis.

Methods

We retrospectively investigated the diagnostic accuracies of histological grades for frozen-section and permanent-section diagnoses from patients with soft-tissue tumors. Frozen-section, permanent-section, and final diagnoses were classified as benign tumors/tumor-like lesions, intermediate malignancies, or malignant tumors. Diagnostic accuracies of the histological grades from the frozen and permanent sections were evaluated by comparing the final diagnoses for the resected specimens.

Results

The diagnostic accuracies of the histological grades for the frozen- and permanent-section diagnoses were 95% (387/408 lesions) and 97% (395/408 lesions), respectively. Among the tumor types, the diagnostic accuracies of the histological grades for the frozen-section and permanent-section diagnoses were 84% and 87% for adipocytic tumors, 87% and 91% for fibroblastic/myofibroblastic tumors, 99% and 100% for nerve-sheath tumors, 98% and 98% for fibrohistiocytic tumors, 90% and 98% for tumors of uncertain differentiation, 100% and 100% for vascular tumors, and 97% and 98% for other tumors, respectively.

Conclusions

Histological grades from frozen-section diagnoses yielded low diagnostic accuracies in adipocytic and fibroblastic/myofibroblastic tumors. Treatment should be planned based on permanent-section diagnosis and radiological findings for these tumors.
Literatur
2.
Zurück zum Zitat Srisawat PVP, Punyaratabandhu T, Chareonvareekul S, et al. (2014) Comparative study of diagnostic accuracy between office-based closed needle biopsy and open incisional biopsy in patients with musculoskeletal sarcomas. J Med Assoc Thai 97:S30–38PubMed Srisawat PVP, Punyaratabandhu T, Chareonvareekul S, et al. (2014) Comparative study of diagnostic accuracy between office-based closed needle biopsy and open incisional biopsy in patients with musculoskeletal sarcomas. J Med Assoc Thai 97:S30–38PubMed
9.
Zurück zum Zitat Novis DA, Zarbo RJ (1997) Interinstitutional comparison of frozen section turnaround time. A College of American Pathologists Q-Probes study of 32868 frozen sections in 700 hospitals. Arch Pathol Lab Med 121 (6):559-567 Novis DA, Zarbo RJ (1997) Interinstitutional comparison of frozen section turnaround time. A College of American Pathologists Q-Probes study of 32868 frozen sections in 700 hospitals. Arch Pathol Lab Med 121 (6):559-567
15.
Zurück zum Zitat Howanitz PJ, Hoffman GG, Zarbo RJ (1990) The accuracy of frozen-section diagnoses in 34 hospitals. Arch Pathol Lab Med 114(4):355–359PubMed Howanitz PJ, Hoffman GG, Zarbo RJ (1990) The accuracy of frozen-section diagnoses in 34 hospitals. Arch Pathol Lab Med 114(4):355–359PubMed
16.
Zurück zum Zitat Shah MS, Garg V, Kapoor SK, et al. (2003) Fine-needle aspiration cytology, frozen section, and open biopsy: relative significance in diagnosis of musculoskeletal tumors. J Surg Orthop Adv 12(4):203–207PubMed Shah MS, Garg V, Kapoor SK, et al. (2003) Fine-needle aspiration cytology, frozen section, and open biopsy: relative significance in diagnosis of musculoskeletal tumors. J Surg Orthop Adv 12(4):203–207PubMed
17.
Zurück zum Zitat Fletcher CDM, Unni KK, Mertens F (2002) WHO classification of tumours of soft tissue and bone, 3rd edn. IARC Press, Lyon Fletcher CDM, Unni KK, Mertens F (2002) WHO classification of tumours of soft tissue and bone, 3rd edn. IARC Press, Lyon
18.
Zurück zum Zitat Fletcher CDM, Bridge JA, Hogendoorn P, et al. (2013) WHO classification of tumours of the soft tissues and bone. IARC Press, Lyon Fletcher CDM, Bridge JA, Hogendoorn P, et al. (2013) WHO classification of tumours of the soft tissues and bone. IARC Press, Lyon
21.
Zurück zum Zitat Dalal BL, Malik AK, Datta BN (1979) Frozen section diagnosis--a review of 1051 cases. Indian J Cancer 16 (2) Dalal BL, Malik AK, Datta BN (1979) Frozen section diagnosis--a review of 1051 cases. Indian J Cancer 16 (2)
25.
Zurück zum Zitat Yamamoto N, Hayashi K, Tanzawa Y, et al. (2012) Treatment strategies for well-differentiated liposarcomas and therapeutic outcomes. Anticancer Res 32(5):1821–1825PubMed Yamamoto N, Hayashi K, Tanzawa Y, et al. (2012) Treatment strategies for well-differentiated liposarcomas and therapeutic outcomes. Anticancer Res 32(5):1821–1825PubMed
27.
Zurück zum Zitat Kimura H, Dobashi Y, Nojima T, et al. (2013) Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas and their morphological mimics. Int J Clin Exp Pathol 6(7):1306–1316PubMedPubMedCentral Kimura H, Dobashi Y, Nojima T, et al. (2013) Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas and their morphological mimics. Int J Clin Exp Pathol 6(7):1306–1316PubMedPubMedCentral
Metadaten
Titel
Accuracy of histological grades from intraoperative frozen-section diagnoses of soft-tissue tumors
verfasst von
Shinji Miwa
Norio Yamamoto
Katsuhiro Hayashi
Akihiko Takeuchi
Kentaro Igarashi
Kaoru Tada
Takashi Higuchi
Hirotaka Yonezawa
Sei Morinaga
Yoshihiro Araki
Yohei Asano
Hiroko Ikeda
Takayuki Nojima
Hiroyuki Tsuchiya
Publikationsdatum
10.08.2020
Verlag
Springer Singapore
Erschienen in
International Journal of Clinical Oncology / Ausgabe 12/2020
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-020-01762-2

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