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Medical Oncology

Erschienen in:

01.06.2011 | Original Paper

Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma

verfasst von: Maciej Machaczka, Johan Vaktnäs, Monika Klimkowska, Hareth Nahi, Hans Hägglund

Erschienen in: Medical Oncology | Ausgabe 2/2011

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Abstract

Acquired or secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammation syndrome caused mostly by various infectious agents, autoimmune disorders or malignancy. So far, only anecdotal cases of sHLH associated with multiple myeloma have been published. We provide a review of all these reports and include a previously not published case of myeloma-associated sHLH in a 59-year-old male with complex partial epilepsy. Due to aggressive course of sHLH, increased awareness is indicated in all patients with malignancies which develop unremitting fever, cytopenia and splenomegaly. Early diagnosis and immediate introduction of adequate therapy is crucial for the outcome of HLH.

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Titel: Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma
verfasst von: Maciej Machaczka
Johan Vaktnäs
Monika Klimkowska
Hareth Nahi
Hans Hägglund
Publikationsdatum: 01.06.2011
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 2/2011
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-010-9484-5

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Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma

Abstract

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Abstract

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