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Seminars in Immunopathology

Erschienen in:

02.07.2018 | Review

Acquired resistance to cancer immunotherapy

verfasst von: Arianna Draghi, Christopher Aled Chamberlain, Andrew Furness, Marco Donia

Erschienen in: Seminars in Immunopathology | Ausgabe 1/2019

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Abstract

In recent times, advances in cancer immunotherapy have yielded impressive, durable clinical responses in patients with varied subtypes of cancer. However, a significant proportion of patients who initially demonstrate encouraging tumor regression develop resistance and progress over time. The identification of novel therapeutic approaches to overcome resistance may result in significantly improved clinical outcomes and remains an area of high scientific priority. This review aims to summarize the current knowledge regarding the role of both tumor-intrinsic and tumor-extrinsic factors in the development of resistance to cancer immunotherapy and to discuss current and possible future therapeutic strategies targeting these mechanisms.

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Titel: Acquired resistance to cancer immunotherapy
verfasst von: Arianna Draghi
Christopher Aled Chamberlain
Andrew Furness
Marco Donia
Publikationsdatum: 02.07.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 1/2019
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-018-0692-y

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