Ausgabe 1/2018
Inhalt (13 Artikel)
The lysosomal function of progranulin, a guardian against neurodegeneration
Daniel H. Paushter, Huan Du, Tuancheng Feng, Fenghua Hu
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain
Wei Hong, Zemin Wang, Wen Liu, Tiernan T. O’Malley, Ming Jin, Michael Willem, Christian Haass, Matthew P. Frosch, Dominic M. Walsh
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Maitrayee Sardar Sinha, Anna Ansell-Schultz, Livia Civitelli, Camilla Hildesjö, Max Larsson, Lars Lannfelt, Martin Ingelsson, Martin Hallbeck
Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART
Sarah K. Kaufman, Kelly Del Tredici, Talitha L. Thomas, Heiko Braak, Marc I. Diamond
Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders
Brian Spencer, Sven Brüschweiler, Marco Sealey-Cardona, Edward Rockenstein, Anthony Adame, Jazmin Florio, Michael Mante, Ivy Trinh, Robert A. Rissman, Robert Konrat, Eliezer Masliah
Aging alters the immunological response to ischemic stroke
Rodney M. Ritzel, Yun-Ju Lai, Joshua D. Crapser, Anita R. Patel, Anna Schrecengost, Jeremy M. Grenier, Nickolas S. Mancini, Anthony Patrizz, Evan R. Jellison, Diego Morales-Scheihing, Venugopal R. Venna, Julia K. Kofler, Fudong Liu, Rajkumar Verma, Louise D. McCullough
CADASIL brain vessels show a HTRA1 loss-of-function profile
Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F. Lichtenthaler, Stephan A. Müller, Martin Dichgans, Christof Haffner
Gadolinium-based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study
Stefanie Fingerhut, Michael Sperling, Markus Holling, Thomas Niederstadt, Thomas Allkemper, Alexander Radbruch, Walter Heindel, Werner Paulus, Astrid Jeibmann, Uwe Karst
Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways
Nazira J. Albargothy, David A. Johnston, Matthew MacGregor-Sharp, Roy O. Weller, Ajay Verma, Cheryl A. Hawkes, Roxana O. Carare
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas
Mitsuaki Shirahata, Takahiro Ono, Damian Stichel, Daniel Schrimpf, David E. Reuss, Felix Sahm, Christian Koelsche, Annika Wefers, Annekathrin Reinhardt, Kristin Huang, Philipp Sievers, Hiroaki Shimizu, Hiroshi Nanjo, Yusuke Kobayashi, Yohei Miyake, Tomonari Suzuki, Jun-ichi Adachi, Kazuhiko Mishima, Atsushi Sasaki, Ryo Nishikawa, Melanie Bewerunge-Hudler, Marina Ryzhova, Oksana Absalyamova, Andrey Golanov, Peter Sinn, Michael Platten, Christine Jungk, Frank Winkler, Antje Wick, Daniel Hänggi, Andreas Unterberg, Stefan M. Pfister, David T. W. Jones, Martin van den Bent, Monika Hegi, Pim French, Brigitta G. Baumert, Roger Stupp, Thierry Gorlia, Michael Weller, David Capper, Andrey Korshunov, Christel Herold-Mende, Wolfgang Wick, David N. Louis, Andreas von Deimling
Novel FGFR2-INA fusion identified in two low-grade mixed neuronal-glial tumors drives oncogenesis via MAPK and PI3K/mTOR pathway activation
Payal Jain, Lea F. Surrey, Joshua Straka, Minjie Luo, Fumin Lin, Brian Harding, Adam C. Resnick, Phillip B. Storm, Anna Maria Buccoliero, Mariarita Santi, Marilyn M. Li, Angela J. Waanders
A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”
André O. von Bueren, Michael Karremann, Gerrit H. Gielen, Martin Benesch, Maryam Fouladi, Dannis G. van Vuurden, Sophie E. M. Veldhuijzen van Zanten, Lindsey M. Hoffman, Christof M. Kramm
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution
Henning Leske, Elisabeth Rushing, Herbert Budka, Pitt Niehusmann, Jens Pahnke, Ioannis Panagopoulos