Ausgabe 1/2020
Inhalt (14 Artikel)
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
Morvane Colin, Simon Dujardin, Susanna Schraen-Maschke, Guy Meno-Tetang, Charles Duyckaerts, Jean-Philippe Courade, Luc Buée
Evidence of corticofugal tau spreading in patients with frontotemporal dementia
Eun-Joo Kim, Ji-Hye L. Hwang, Stephanie E. Gaus, Alissa L. Nana, Jersey Deng, Jesse A. Brown, Salvatore Spina, Myung Jun Lee, Eliana Marisa Ramos, Lea T. Grinberg, Joel H. Kramer, Adam L. Boxer, Maria Luisa Gorno-Tempini, Howard J. Rosen, Bruce L. Miller, William W. Seeley
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
Zeran Li, Fabiana H. G. Farias, Umber Dube, Jorge L. Del-Aguila, Kathie A. Mihindukulasuriya, Maria Victoria Fernandez, Laura Ibanez, John P. Budde, Fengxian Wang, Allison M. Lake, Yuetiva Deming, James Perez, Chengran Yang, Jorge A. Bahena, Wei Qin, Joseph L. Bradley, Richard Davenport, Kristy Bergmann, John C. Morris, Richard J. Perrin, Bruno A. Benitez, Joseph D. Dougherty, Oscar Harari, Carlos Cruchaga
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration
Eri Saijo, Michael A. Metrick II, Shunsuke Koga, Piero Parchi, Irene Litvan, Salvatore Spina, Adam Boxer, Julio C. Rojas, Douglas Galasko, Allison Kraus, Marcello Rossi, Kathy Newell, Gianluigi Zanusso, Lea T. Grinberg, William W. Seeley, Bernardino Ghetti, Dennis W. Dickson, Byron Caughey
Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases
Ian R. Mackenzie, Manuela Neumann
Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Yoshihiro Nihei, Kohji Mori, Georg Werner, Thomas Arzberger, Qihui Zhou, Barham Khosravi, Julia Japtok, Andreas Hermann, Andreas Sommacal, Markus Weber, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass
Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis
Patrick Oeckl, Patrick Weydt, Dietmar R. Thal, Jochen H. Weishaupt, Albert C. Ludolph, Markus Otto
White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy
Conceição Bettencourt, Sandrine C. Foti, Yasuo Miki, Juan Botia, Aparajita Chatterjee, Thomas T. Warner, Tamas Revesz, Tammaryn Lashley, Robert Balazs, Emmanuelle Viré, Janice L. Holton
NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation
Yanan Yu, Kwangmin Choi, Jianqiang Wu, Paul R. Andreassen, Phillip J. Dexheimer, Mehdi Keddache, Hilde Brems, Robert J. Spinner, Jose A. Cancelas, Lisa J. Martin, Margaret R. Wallace, Eric Legius, Kristine S. Vogel, Nancy Ratner
FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas
Frank Brand, Alisa Förster, Anne Christians, Martin Bucher, Carina M. Thomé, Marc S. Raab, Manfred Westphal, Torsten Pietsch, Andreas von Deimling, Guido Reifenberger, Peter Claus, Bettina Hentschel, Michael Weller, Ruthild G. Weber
Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course
Annika K. Wefers, Damian Stichel, Daniel Schrimpf, Roland Coras, Mélanie Pages, Arnault Tauziède-Espariat, Pascale Varlet, Daniel Schwarz, Figen Söylemezoglu, Ute Pohl, José Pimentel, Jochen Meyer, Ekkehard Hewer, Anna Japp, Abhijit Joshi, David E. Reuss, Annekathrin Reinhardt, Philipp Sievers, M. Belén Casalini, Azadeh Ebrahimi, Kristin Huang, Christian Koelsche, Hu Liang Low, Olinda Rebelo, Dina Marnoto, Albert J. Becker, Ori Staszewski, Michel Mittelbronn, Martin Hasselblatt, Jens Schittenhelm, Edmund Cheesman, Ricardo Santos de Oliveira, Rosane Gomes P. Queiroz, Elvis Terci Valera, Volkmar H. Hans, Andrey Korshunov, Adriana Olar, Keith L. Ligon, Stefan M. Pfister, Zane Jaunmuktane, Sebastian Brandner, Ruth G. Tatevossian, David W. Ellison, Thomas S. Jacques, Mrinalini Honavar, Eleonora Aronica, Maria Thom, Felix Sahm, Andreas von Deimling, David T. W. Jones, Ingmar Blumcke, David Capper
YAP1-fusions in pediatric NF2-wildtype meningioma
Philipp Sievers, Jason Chiang, Daniel Schrimpf, Damian Stichel, Nagarajan Paramasivam, Martin Sill, Tenzin Gayden, Belen Casalini, David E. Reuss, James Dalton, Kristian W. Pajtler, Daniel Hänggi, Christel Herold-Mende, Elisabeth Rushing, Andrey Korshunov, Christian Mawrin, Michael Weller, Matthias Schlesner, Wolfgang Wick, Nada Jabado, David T. W. Jones, Stefan M. Pfister, Andreas von Deimling, David W. Ellison, Felix Sahm
Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls
Daniel Erskine, Amy K. Reeve, Tuomo Polvikoski, Andrew M. Schaefer, Robert W. Taylor, Nichola Z. Lax, Omar El-Agnaf, Johannes Attems, Gráinne S. Gorman, Doug M. Turnbull, Yi Shau Ng