Ausgabe 4/2019
Inhalt (12 Artikel)
Translational control in brain pathologies: biological significance and therapeutic opportunities
Alberto Delaidelli, Asad Jan, Jochen Herms, Poul H. Sorensen
Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease
Stephen A. Semick, Rahul A. Bharadwaj, Leonardo Collado-Torres, Ran Tao, Joo Heon Shin, Amy Deep-Soboslay, James R. Weiss, Daniel R. Weinberger, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe, Venkata S. Mattay
Tau drives translational selectivity by interacting with ribosomal proteins
Shon A. Koren, Matthew J. Hamm, Shelby E. Meier, Blaine E. Weiss, Grant K. Nation, Emad A. Chishti, Juan Pablo Arango, Jing Chen, Haining Zhu, Eric M. Blalock, Jose F. Abisambra
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
Allison Kraus, Eri Saijo, Michael A. Metrick II, Kathy Newell, Christina J. Sigurdson, Gianluigi Zanusso, Bernardino Ghetti, Byron Caughey
Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave, Dick Terwel, Ilse Dewachter
Microglial nodules provide the environment for pathogenic T cells in human encephalitis
Anna R. Tröscher, Isabella Wimmer, Lucía Quemada-Garrido, Ulrike Köck, Denise Gessl, Sanne G. S. Verberk, Bethany Martin, Hans Lassmann, Christian G. Bien, Jan Bauer
H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo
André B. Silveira, Lawryn H. Kasper, Yiping Fan, Hongjian Jin, Gang Wu, Timothy I. Shaw, Xiaoyan Zhu, Jon D. Larson, John Easton, Ying Shao, Donald A. Yergeau, Celeste Rosencrance, Kristy Boggs, Michael C. Rusch, Liang Ding, Junyuan Zhang, David Finkelstein, Rachel M. Noyes, Brent L. Russell, Beisi Xu, Alberto Broniscer, Cynthia Wetmore, Stanley B. Pounds, David W. Ellison, Jinghui Zhang, Suzanne J. Baker
TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma
Malte Hellwig, Marlen C. Lauffer, Michael Bockmayr, Michael Spohn, Daniel J. Merk, Luke Harrison, Julia Ahlfeld, Annabel Kitowski, Julia E. Neumann, Jasmin Ohli, Dörthe Holdhof, Judith Niesen, Melanie Schoof, Marcel Kool, Cornelia Kraus, Christiane Zweier, Dan Holmberg, Ulrich Schüller
SHH medulloblastoma in a young adult with a TCF4 germline pathogenic variation
Maud Blanluet, Julien Masliah-Planchon, Irina Giurgea, Franck Bielle, Elodie Girard, Mamy Andrianteranagna, Stéphane Clemenceau, Christine Bourneix, Lydie Burglen, Diane Doummar, Audrey Rapinat, Badreddine Mohand Oumoussa, Olivier Ayrault, Celio Pouponnot, David Gentien, Gaëlle Pierron, Olivier Delattre, François Doz, Franck Bourdeaut
Prognostic significance of NAB2–STAT6 fusion variants and TERT promotor mutations in solitary fibrous tumors/hemangiopericytomas of the CNS: not (yet) clear
Rob Vogels, Nicolas Macagno, Klaus Griewank, Patricia Groenen, Marian Verdijk, Judy Fonville, Benno Kusters, Corinne Bouvier, Philippe Cornu, Henry Dufour, Dominique Figarella-Branger, Jacques Guyotat, Anne Jouvet, Nicolas Macagno, Philippe Métellus, Karima Mokhtari, Alexandre Vasiljevic, Pascale Varlet, R. Vogels, U. Flucke, B. Küsters, P. Groenen, P. Wesseling, E. Bekers, M. Verdijk, M. Djafarihamedani, E. Kurt, H. Küsters-Vandevelde, R. Fleischeuer, S. Leenstra, P. Robe, W. Spliet, D. Troost, W. van Furth, Dominique Figarella-Branger, Pieter Wesseling, Corinne Bouvier, Uta Flucke
cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation
David W. Ellison, Cynthia Hawkins, David T. W. Jones, Arzu Onar-Thomas, Stefan M. Pfister, Guido Reifenberger, David N. Louis