Case report
Pathohistology of liver metastases
Pathohistology of pituitary tumor
Next-generation-sequencing
Sanger-sequencing
Test | Result preoperative | Results 3rd postoperative day | Reference range |
---|---|---|---|
ACTH | 3534 | 3360 | ~ 46 ng/l |
Cortisol | 1621 | 1835 | 52,7–224 µg/l |
GH | <0.15 | <0.15 | ~ 16 mU/l |
IGF-1 | 55.6 | 50.3 | 48–209 µg/l |
TSH | 0,04 | 0.04 | 0.55–4.76 mU/l |
fT4 | 16.3 | 11.5 | 11.5–22.7 pmol/l |
fT3 | 3.0 | 2.1 | 4.5–6.5 pmol/l |
FSH | 0.6 | 0.5 | 1.4–18.1 U/l |
LH | <0.07 | <0.07 | 1.5–9.3 U/l |
Testosterone | 3.87 | 3.13 | 0.86–7.88 µg/l |
Prolactin | 2.1 | 1.8 | 2.1–17.7 µg/l |
Potassium | 2.5 | 3.2 | 3.5–4.6 mmol/l |
Sodium | 136 | 137 | 135–145 mmol/l |
Test | Results | Reference range |
---|---|---|
AST | 109 | <50 U/l |
ALT | 146 | <50 U/l |
GGT | 12888 | <73 U/l |
ALP | 223 | 46–116 U/l |
Tissue | ACTH | Ki-67 | Mitoses per 10 HPF | p53 | T-Pit | synaptophysin | chromogranin |
---|---|---|---|---|---|---|---|
Pituitary | Strong | 60% | 20 | ~100% | Positive | Strongly positive | Negative |
Liver | Strong | 60% | 20 | ~100% | Negative | Strongly positive | Strongly positive |
Pat. No. | Gene | CDS mutation | AA mutation | Germline(G)/primary tumor (PT)/metastasis(M) | Authors & year |
---|---|---|---|---|---|
1 | ATRX | c.134_6217del | p.D45-K2027del | PT | Casar-Borota et al. 2021 |
2 | c.748C > T | p.Arg250Ter | PT | ||
3 | c.6679delG c.3583delA | p.Asp2227fs p.Arg1195fs | PT | ||
4 | c.4048_4049delGG c.6661G > T | p.Gly1350fs p.Glu2221Ter | PT | ||
4 | c.4048_4049delGG | p.Gly1350fs | M | ||
5 | c.595_6699del | p.N199-K2233del | PT and M | ||
6 | Deletion of exon 3 to 27 | No data | PT and M | Casar-Borota et al. 2017 | |
7 | No data | No data | Not mentioned | Guo et al. 2018 | |
5 | CDKN2A | c.1_501del | p.M1-A167del | PT and M | Casar-Borota et al. 2021 |
5 | CDKN2B | c.1_414del | p.M1-D138del | PT and M | |
8 | H-Ras | c.34G > C | p.G12R | M | Pei et al. 1994 |
9 | c.52G > A | p.A18T | M | ||
10 | Codon 3 del | - | M | ||
11 | MSH2 | c.1587delA | p.E530Kfs | G | Bengtsson et. al. 2007 |
7 | PTEN | No data | No data | Not mentioned | Guo et al. 2018 |
12 | SDHB | c.587G > A | p.Cys196Try | PT | Tufton et al. 2017 |
2 | TP53 | c.524G > A | p.Arg175His | PT | Casar-Borota et al. 2021 |
4 | c.644G > A | p.Ser215Asn | PT | ||
7 | No data | No data | Not mentioned | Guo et al. 2018 | |
13 | c.742C > G | p.R248G | PT | Tanizaki et al. 2007 | |
14 | c.404G > T | p.C135F | PT |