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01.11.2013 | Review

Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling

verfasst von: Juan Felipe Cardona, Oscar Gershanik, Carlos Gelormini-Lezama, Alexander Lee Houck, Sebastian Cardona, Lucila Kargieman, Natalia Trujillo, Analía Arévalo, Lucia Amoruso, Facundo Manes, Agustín Ibáñez

Erschienen in: Brain Structure and Function | Ausgabe 6/2013

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Abstract

Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson’s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical–subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action–perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.

Abdullaev YG, Melnichuk KV (1997) Cognitive operations in the human caudate nucleus. Neurosci Lett 234:151–155PubMed

Amoruso L, Couto B, Ibáñez A (2011) Beyond extrastriate body area (EBA) and fusiform body area (FBA): context integration in the meaning of actions. Front Hum Neurosci 5:124. doi:10.3389/fnhum.2011.00124 PubMed

Amoruso L, Cardona J, Melloni M, Sedeño L, Ibanez A (2012) Contextual impairments in Schizophrenia and the FN400. Front Hum Neurosci 6:191. doi:10.3389/fnhum.2012.00191 PubMed

Angwin AJ, Chenery HJ, Copland D, Murdoch BE, Silburn PA (2006) Self-paced reading and sentence comprehension in Parkinson’s disease. J Neuroling 19:239–252

Antzoulatos EG, Miller EK (2011) Differences between neural activity in prefrontal cortex and striatum during learning of novel abstract categories. Neuron 71:243–249PubMed

Aravena P, Hurtado E, Riveros R, Cardona JF, Manes F, Ibáñez A (2010) Applauding with closed hands: neural signature of action-sentence compatibility effects. PLoS ONE 5:e11751

Arbib MA (2010) Mirror system activity for action and language is embedded in the integration of dorsal and ventral pathways. Brain Lang 112:12–24PubMed

Arevalo AL, Baldo JV, Dronkers NF (2012) What do brain lesions tell us about theories of embodied semantics and the human mirror neuron system? Cortex 48:242–254PubMed

Arnott WL, Chenery HJ, Murdoch BE, Silburn PA (2005) Morphosyntactic and syntactic priming: an investigation of underlying processing mechanisms and the effects of Parkinson’s disease. J Neuroling 18:1–28

Ashby FG, Turner BO, Horvitz JC (2010) Cortical and basal ganglia contributions to habit learning and automaticity. Trends Cogn Sci 14:208–215PubMed

Aziz-Zadeh L (2012) Embodied semantics for language related to actions: a review of fMRI and neuropsychological research. In: Coello Y, Bartolo A (eds) Language and action in cognitive neuroscience. Psychology Press, London

Aziz-Zadeh L, Wilson SM, Rizzolatti G, Iacoboni M (2006) Congruent embodied representations for visually presented actions and linguistic phrases describing actions. Curr Biol 16:1818–1823PubMed

Bak TH, Hodges JR (2004) The effects of motor neurone disease on language: further evidence. Brain Lang 89:354–361PubMed

Bak TH, O’Donovan DG, Xuereb JH, Boniface S, Hodges JR (2001) Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome. Brain 124:103–120PubMed

Bak TH, Yancopoulou D, Nestor PJ, Xuereb JH, Spillantini MG, Pulvermüller F, Hodges JR (2006) Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing. Brain 129:321–332PubMed

Berg E, Bjornram C, Hartelius L, Laakso K, Johnels B (2003) High-level language difficulties in Parkinson’s disease. Clin Linguist Phon 17:63–80PubMed

Bertella L, Albani G, Greco E, Priano L, Mauro A, Marchi S, Bulla D, Semenza C (2002) Noun verb dissociation in Parkinson’s disease. Brain Cogn 48:277–280PubMed

Booth JR, Wood L, Lu D, Houk JC, Bitan T (2007) The role of the basal ganglia and cerebellum in language processing. Brain Res 1133:136–144PubMed

Boulenger V, Mechtouff L, Thobois S, Broussolle E, Jeannerod M, Nazir TA (2008) Word processing in Parkinson’s disease is impaired for action verbs but not for concrete nouns. Neuropsychologia 46:743–756PubMed

Brass M, Schmitt RM, Spengler S, Gergely G (2007) Investigating action understanding: inferential processes versus action simulation. Curr Biol 17:2117–2121PubMed

Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, Seitz RJ, Zilles K, Rizzolatti G, Freund HJ (2001) Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study. Eur J Neurosci 13:400–404PubMed

Calabresi P, Picconi B, Parnetti L, Di FM (2006) A convergent model for cognitive dysfunctions in Parkinson’s disease: the critical dopamine-acetylcholine synaptic balance. Lancet Neurol 5:974–983PubMed

Cappa SF, Binetti G, Pezzini A, Padovani A, Rozzini L, Trabucchi M (1998) Object and action naming in Alzheimer’s disease and frontotemporal dementia. Neurology 50:351–355PubMed

Copland D (2003) The basal ganglia and semantic engagement: potential insights from semantic priming in individuals with subcortical vascular lesions, Parkinson’s disease, and cortical lesions. J Int Neuropsychol Soc 9:1041–1052PubMed

Cotelli M, Borroni B, Manenti R, Zanetti M, Arevalo A, Cappa SF, Padovani A (2007) Action and object naming in Parkinson’s disease without dementia. Eur J Neurol 14:632–637PubMed

Couto B, Sedeño L, Sposato LA, Sigman M, Riccio PM, Salles A, Lopez V, Schroeder J, Manes F, Ibanez A (2012) Insular networks for emotional processing and social cognition: comparison of two case reports with either cortical or subcortical involvement. Cortex 5. pii:S0010-9452(12)00245-6

Crescentini C, Mondolo F, Biasutti E, Shallice T (2008) Supervisory and routine processes in noun and verb generation in nondemented patients with Parkinson’s disease. Neuropsychologia 46:434–447PubMed

Crosson B, Benefield H, Cato MA, Sadek JR, Moore AB, Wierenga CE, Gopinath K, Soltysik D, Bauer RM, Auerbach EJ, Gokcay D, Leonard CM, Briggs RW (2003) Left and right basal ganglia and frontal activity during language generation: contributions to lexical, semantic, and phonological processes. J Int Neuropsychol Soc 9:1061–1077PubMed

Cummings JL (1990) Subcortical dementia. Oxford University Press, New York

Cummings JL, Darkins A, Mendez M, Hill MA, Benson DF (1988) Alzheimer’s disease and Parkinson’s disease: comparison of speech and language alterations. Neurology 38:680–684PubMed

D’Ausilio A, Pulvermüller F, Salmas P, Bufalari I, Begliomini C, Fadiga L (2009) The motor somatotopy of speech perception. Curr Biol 19:381–385PubMed

de Zubicaray G, Postle N, McMahon K, Meredith M, Ashton R (2010) Mirror neurons, the representation of word meaning, and the foot of the third left frontal convolution. Brain Lang 112:77–84PubMed

Decety J, Grèzes J (2006) The power of simulation: imagining one’s own and other’s behavior. Brain Res 1079:4–14PubMed

Delong MR (1971) Activity of pallidal neurons during movement. J Neurophysiol 34:414–427PubMed

Delong MR (1973) Putamen: activity of single units during slow and rapid arm movements. Science 179:1240–1242PubMed

Demakis GJ, Mercury MG, Sweet JJ, Rezak M, Eller T, Vergenz S (2003) Qualitative analysis of verbal fluency before and after unilateral pallidotomy. Clin Neuropsychol 17:322–330

d’Honincthun P, Pillon A (2008) Verb comprehension and naming in frontotemporal degeneration: the role of the static depiction of actions. Cortex 44:834–847PubMed

Dubois B, Pillon B (1997) Cognitive deficits in Parkinson’s disease. J Neurol 244:2–8PubMed

Eickhoff SB, Heim S, Zilles K, Amunts K (2009) A systems perspective on the effective connectivity of over speech production. Phil Trans R Soc A 367:2399–2421PubMed

Fernandino L, Iacoboni M (2010) Are cortical motor maps based on body parts or coordinated actions? Implications for embodied semantics. Brain Lang 112:44–53PubMed

Fernandino L, Conant LL, Binder JR, Blindauer K, Hiner B, Spangler K, Desai RH (2012) Parkinson’s disease disrupts both automatic and controlled processing of action verbs. Brain Lang. http://dx.doi.org/10.1016/j.bandl.2012.07.008

Fischer MH, Zwaan RA (2008) Embodied language: a review of the role of the motor system in language comprehension. Q J Exp Psychol (Colchester) 61:825–850

Friederici AD (2002) Towards a neural basis of auditory sentence processing. Trends Cogn Sci 6:78–84PubMed

Friederici AD, von Cramon DY, Kotz SA (1999) Language related brain potentials in patients with cortical and subcortical left hemisphere lesions. Brain 122(Pt 6):1033–1047PubMed

Friederici AD, Kotz SA, Werheid K, Hein G, von Cramon DY (2003a) Syntactic comprehension in Parkinson’s disease: investigating early automatic and late integrational processes using event-related brain potentials. Neuropsychology 17:133–142PubMed

Friederici AD, Ruschemeyer SA, Hahne A, Fiebach CJ (2003b) The role of left inferior frontal and superior temporal cortex in sentence comprehension: localizing syntactic and semantic processes. Cereb Cortex 13:170–177PubMed

Gallese V (2001) The ‘‘shared manifold’’ hypothesis: from mirror neurons to empathy. JCS 8:33–50

Gallese V, Lakoff G (2005) The brain’s concepts: the role of the sensorimotor system in reason and language. Cogn Neuropsychol 22:455–479PubMed

Gallese V, Sinigaglia C (2011) What is so special about embodied simulation? Trends Cogn Sci 11:512–519

Gallese V, Fadiga L, Fogassi L, Rizzolatti G (1996) Action recognition in the premotor cortex. Brain 119:593–609PubMed

Gallese V, Keysers C, Rizzolatti G (2004) A unifying view of the basis of social cognition. Trends Cogn Sci 8:396–403PubMed

Gazzola V, Keysers C (2009) The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data. Cereb Cortex 19:1239–1255PubMed

Glenberg AM, Sato M, Cattaneo L, Riggio L, Palumbo D, Buccino G (2008) Processing abstract language modulates motor system activity. Q J Exp Psychol (Hove) 61:905–919

Grahn JA, Parkinson JA, Owen AM (2008) The cognitive functions of the caudate nucleus. Prog Neurobiol 86:141–155PubMed

Graybiel AM (2008) Habits, rituals, and the evaluative brain. Annu Rev Neurosci 31:359–387PubMed

Grezes J, Decety J (2001) Functional anatomy of execution, mental simulation, observation, and verb generation of actions: a meta-analysis. Hum Brain Mapp 12:1–19PubMed

Grossman M, Cooke A, DeVita C, Lee C, Alsop D, Detre J, Gee J, Chen W, Stern MB, Hurtig HI (2003) Grammatical and resource components of sentence processing in Parkinson’s disease: an fMRI study. Neurology 60:775–781PubMed

Hagoort P (1993) Impairments of lexical-semantic processing in aphasia: evidence from the processing of lexical ambiguities. Brain Lang 45:189–232PubMed

Hauk O, Johnsrude I, Pulvermüller F (2004) Somatotopic representation of action words in human motor and premotor cortex. Neuron 41:301–307PubMed

Hebb DO (1949) The organization of behavior. In: A neuropsychological theory. John Wiley, New York

Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012) Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain. doi:10.1093/brain/aws023

Herrera E, Cuetos F (2012) Action naming in Parkinson’s disease patients on/off dopamine. Neurosci Lett 513:219–222PubMed

Heyes C (2010) Mesmerising mirror neurons. Neuroimage 51:789–791PubMed

Hickok G (2009) Eight problems for the mirror neuron theory of action understanding in monkeys and humans. J Cogn Neurosci 21:1229–1243PubMed

Hickok G (2010) The role of mirror neurons in speech and language processing. Brain Lang 112:1–2PubMed

Hickok G, Costanzo M, Capasso R, Miceli G (2011) The role of Broca’s area in speech perception: evidence from aphasia revisited. Brain Lang 119:214–220PubMed

Hochstadt J, Nakano H, Lieberman P, Friedman J (2006) The roles of sequencing and verbal working memory in sentence comprehension deficits in Parkinson’s disease. Brain Lang 97:243–257PubMed

Houk JC (2005) Agents of the mind. Biol Cybern 92:427–437PubMed

Ibañez A, Manes F (2012) Contextual social cognition and the behavioral variant of frontotemporal dementia. Neurology 78:1354–1362PubMed

Ibáñez A, Cardona JF, Vidal Y, Blenkman A, Aravena P, Roca M, Hurtado E, Nerguizian M, Amoruso L, Gómez-Arévalo G, Chade A, Dubrovsky A, Gershanik O, Kochen S, Glenberg A, Manes F, Bekinschtein T (2012) Motor-language coupling: direct evidence from early Parkinson’s disease and intracranial cortical recordings. Cortex. doi:10.1016/j.cortex.2012.02.014

Kemmerer D, Gonzalez-Castillo J (2010) The two-level theory of verb meaning: an approach to integrating the semantics of action with the mirror neuron system. Brain Lang 112:54–76PubMed

Knowlton BJ, Mangels JA, Squire LR (1996) A neostriatal habit learning system in humans. Science 273:1399–1402PubMed

Kornhuber HH (1971) Motor functions of cerebellum and basal ganglia: the cerebellocortical saccadic (ballistic) clock, the cerebellonuclear hold regulator, and the basal ganglia ramp (voluntary speed smooth movement) generator. Kybernetik 8:157–162PubMed

Kotz SA, Schwartze M, Schmidt-Kassow M (2009) Non-motor basal ganglia functions: a review and proposal for a model of sensory predictability in auditory language perception. Cortex 45:982–990PubMed

Lee C, Grossman M, Morris J, Stern MB, Hurtig HI (2003) Attentional resource and processing speed limitations during sentence processing in Parkinson’s disease. Brain Lang 85:347–356PubMed

Lehericy S, Ducros M, Van de Moortele PF, Francois C, Thivard L, Poupon C, Swindale N, Ugurbil K, Kim DS (2004) Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans. Ann Neurol 55:522–529PubMed

Lewis SJ, Dove A, Robbins TW, Barker RA, Owen AM (2003) Cognitive impairments in early Parkinson’s disease are accompanied by reductions in activity in frontostriatal neural circuitry. J Neurosci 23:6351–6356PubMed

Lieberman P, Kako E, Friedman J, Tajchman G, Feldman LS, Jiminez EB (1992) Speech production, syntax comprehension, and cognitive deficits in Parkinson’s disease. Brain Lang 43:169–189PubMed

Liu W, McIntire K, Kim SH, Zhang J, Dascalos S, Lyons KE, Pahwa R (2006) Bilateral subthalamic stimulation improves gait initiation in patients with Parkinson’s disease. Gait Posture 23:492–498PubMed

Lo CC, Wang XJ (2006) Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nat Neurosci 9:956–963PubMed

Longworth CE, Keenan SE, Barker RA, Marslen-Wilson WD, Tyler LK (2005) The basal ganglia and rule-governed language use: evidence from vascular and degenerative conditions. Brain 128:584–596PubMed

Louwerse MM, Jeuniaux P (2008) How fundamental is embodiment to language comprehension? Constraints on embodied cognition. In: Proceedings of the 30th annual conference of the cognitive science society, pp 1313–1318

Mahon BZ, Caramazza A (2008) A critical look at the embodied cognition hypothesis and a new proposal for grounding conceptual content. J Physiol Paris 102:59–70PubMed

McKinlay A, Grace RC, Dalrymple-Alford JC, Roger D (2010) Characteristics of executive function impairment in Parkinson’s disease patients without dementia. J Int Neuropsychol Soc 16:268–277PubMed

McNab F, Klingberg T (2008) Prefrontal cortex and basal ganglia control access to working memory. Nat Neurosci 11:103–107PubMed

Middleton FA, Strick PL (1996) The temporal lobe is a target of output from the basal ganglia. Proc Natl Acad Sci USA 93:8683–8687PubMed

Middleton FA, Strick PL (2000) Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies. Brain Cogn 42:183–200PubMed

Middleton FA, Strick PL (2002) Basal-ganglia ‘projections’ to the prefrontal cortex of the primate. Cereb Cortex 12:926–935PubMed

Mink JW, Thach WT (1993) Basal ganglia intrinsic circuits and their role in behavior. Curr Opin Neurobiol 3:950–957PubMed

Monetta L, Pell MD (2007) Effects of verbal working memory deficits on metaphor comprehension in patients with Parkinson’s disease. Brain Lang 101:80–89PubMed

Moro A, Tettamanti M, Perani D, Donati C, Cappa SF, Fazio F (2001) Syntax and the brain: disentangling grammar by selective anomalies. Neuroimage 13:110–118PubMed

Mottonen R, Calvert GA, Jaaskelainen IP, Matthews PM, Thesen T, Tuomainen J, Sams M (2006) Perceiving identical sounds as speech or non-speech modulates activity in the left posterior superior temporal sulcus. Neuroimage 30:563–569PubMed

Murray LL, Stout JC (1999) Discourse comprehension in Huntington’s and Parkinson’s disease. AJSLP 8:137–148

Muslimovic D, Post B, Speelman JD, Schmand B (2005) Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology 65:1239–1245PubMed

Neary D, Snowden JS, Mann DM (2000) Cognitive change in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). J Neurol Sci 180:15–20PubMed

Negri GA, Rumiati RI, Zadini A, Ukmar M, Mahon BZ, Caramazza A (2007) What is the role of motor simulation in action and object recognition? Evidence from apraxia. Cogn Neuropsychol 24:795–816PubMed

Nelissen K, Borra E, Gerbella M, Rozzi S, Luppino G, Vanduffel W, Rizzolatti G, Orban GA (2011) Action observation circuits in the macaque monkey cortex. J Neurosci 31:3743–3756PubMed

Pasupathy A, Miller EK (2005) Different time courses of learning-related activity in the prefrontal cortex and striatum. Nature 433:873–876PubMed

Patterson K, Nestor PJ, Rogers TT (2007) Where do you know what you know? The representation of semantic knowledge in the human brain. Nat Rev Neurosci 8:976–987PubMed

Penfield W, Boldrey E (1958) Somatic motor and sensory representation in the cerebral cortex as studied by electrical stimulation. Brain 60:389–443

Penfield W, Rasmussen T (1950) The cerebral cortex of man: a clinical study of localization. Macmillan, New York

Peran P, Rascol O, Demonet JF, Celsis P, Nespoulous JL, Dubois B, Cardebat D (2003) Deficit of verb generation in nondemented patients with Parkinson’s disease. Mov Disord 18:150–156PubMed

Peran P, Cardebat D, Cherubini A, Piras F, Luccichenti G, Peppe A, Caltagirone C, Rascol O, Demonet JF, Sabatini U (2009) Object naming and action-verb generation in Parkinson’s disease: a fMRI study. Cortex 45:960–971PubMed

Pobric G, Hamilton AF (2006) Action understanding requires the left inferior frontal cortex. Curr Biol 16:524–529PubMed

Postle N, McMahon KL, Ashton R, Meredith M, de Zubicaray GI (2008) Action word meaning representations in cytoarchitectonically defined primary and premotor cortices. Neuroimage 43:634–644PubMed

Pulvermüller F (1996) Hebb’s concept of cell assemblies and the psychophysiology of word processing. Psychophysiology 33:317–333PubMed

Pulvermüller F (2005) Brain mechanisms linking language and action. Nat Rev Neurosci 6:576–582PubMed

Pulvermüller F, Fadiga L (2010) Active perception: sensorimotor circuits as a cortical basis for language. Nat Rev Neurosci 11:351–360PubMed

Pulvermüller F, Hauk O, Nikulin VV, Ilmoniemi RJ (2005) Functional links between motor and language systems. Eur J Neurosci 21:793–797PubMed

Rhee J, Antiquena P, Grossman M (2001) Verb comprehension in frontotemporal degeneration: the role of grammatical, semantic and executive components. Neurocase 7:173–184PubMed

Rizzolatti G, Craighero L (2004) The mirror-neuron system. Annu Rev Neurosci 27:169–192PubMed

Rizzolatti G, Luppino G (2001) The cortical motor system. Neuron 31:889–901PubMed

Rizzolatti G, Sinigaglia C (2010) The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations. Nat Rev Neurosci 4:264–274

Rizzolatti G, Fogassi L, Gallese V (2001) Neurophysiological mechanisms underlying the understanding and imitation of action. Nat Rev Neurosci 2:661–670PubMed

Rodriguez-Ferreiro J, Menendez M, Ribacoba R, Cuetos F (2009) Action naming is impaired in Parkinson disease patients. Neuropsychologia 47:3271–3274PubMed

Rodriguez-Oroz MC, Jahanshahi M, Krack P, Litvan I, Macias R, Bezard E, Obeso JA (2009) Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms. Lancet Neurol 8:1128–1139PubMed

Rogalsky C, Love T, Driscoll D, Anderson SW, Hickok G (2011) Are mirror neurons the basis of speech perception? Evidence from five cases with damage to the purported human mirror system. Neurocase 17:178–187PubMed

Rosin R, Topka H, Dichgans J (1997) Gait initiation in Parkinson’s disease. Mov Disord 12:682–690PubMed

Rossi E, Schippers M, Keysers C (2011) Broca’s area: linking perception and production in language and actions. In: Han S, Poppel E (eds) Culture and neural frames of cognition. Springer, Berlin, pp 169–184

Sammer G, Reuter I, Hullmann K, Kaps M, Vaitl D (2006) Training of executive functions in Parkinson’s disease. J Neurol Sci 248:115–119PubMed

Saur D, Kreher BW, Schnell S, Kümmerer D, Kellmeyer P, Vry MS, Umarova R, Musso M, Glauche V, Abel S, Huber W, Rijntjes M, Hennig J, Weiller C (2008) Ventral and dorsal pathways for language. Proc Natl Acad Sci USA 105(46):18035–18040PubMed

Saygin AP, Wilson SM, Dronkers NF, Bates E (2004) Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates. Neuropsychologia 42:1788–1804PubMed

Schubotz RI, von Cramon DY (2001) Functional organization of the lateral premotor cortex: fMRI reveals different regions activated by anticipation of object properties, location and speed. Brain Res Cogn 11:97–112

Schubotz RI, von Cramon DY, Lohmann G (2003) Auditory what, where, and when: a sensory somatotopy in lateral premotor cortex. Neuroimage 20:173–185PubMed

Shapiro KA, Moo LR, Caramazza A (2006) Cortical signatures of noun and verb production. Proc Natl Acad Sci USA 103:1644–1649PubMed

Shultz S, Vouloumanos A, Pelphrey K (2012) The superior temporal sulcus differentiates communicative and noncommunicative auditory signals. J Cogn Neurosci 24:1224–1232PubMed

Sinforiani E, Banchieri L, Zucchella C, Pacchetti C, Sandrini G (2004) Cognitive rehabilitation in Parkinson’s disease. Arch Gerontol Geriatr Suppl 9:387–391PubMed

Terzi A, Papapetropoulos S, Kouvelas ED (2005) Past tense formation and comprehension of passive sentences in Parkinson’s disease: evidence from Greek. Brain Lang 94:297–303PubMed

Tomasino B, Fink GR, Sparing R, Dafotakis M, Weiss PH (2008) Action verbs and the primary motor cortex: a comparative TMS study of silent reading, frequency judgments, and motor imagery. Neuropsychologia 46:1915–1926PubMed

Toni I, de Lange FP, Noordzij ML, Hagoort P (2008) Language beyond action. J Physiol Paris 102:71–79PubMed

Torralva T, Roca M, Gleichgerrcht E, Lopez P, Manes F (2009) INECO frontal screening (IFS): a brief, sensitive, and specific tool to assess executive functions in dementia. J Int Neuropsychol Soc 15:777–786PubMed

Torralva T, Roca M, Gleichgerrcht E, Bonifacio A, Raimondi C, Manes F (2011) Validation of the Spanish version of the Addenbrooke’s cognitive examination-revised (ACE-R). Neurologia 6:351–356

Tranel D, Adolphs R, Damasio H, Damasio AR (2001) A neural basis for the retrieval of words for actions. Cogn Neuropsychol 18:655–674PubMed

Tranel D, Kemmerer D, Adolphs R, Damasio H, Damasio AR (2003) Neural correlates of conceptual knowledge for actions. Cogn Neuropsychol 20:409–432PubMed

Tremblay P, Small SL (2011) From language comprehension to action understanding and back again. Cereb Cortex 21:1166–1177PubMed

Ullman MT (2006) Is Broca’s area part of a basal ganglia thalamocortical circuit? Cortex 42:480–485PubMed

Vitek JL, Giroux M (2000) Physiology of hypokinetic and hyperkinetic movement disorders: model for dyskinesia. Ann Neurol 47:S131–S140PubMed

Willems RM, Hagoort P (2007) Neural evidence for the interplay between language, gesture, and action: a review. Brain Lang 101:278–289PubMed

Woods SP, Troster AI (2003) Prodromal frontal/executive dysfunction predicts incident dementia in Parkinson’s disease. J Int Neuropsychol Soc 9:17–24PubMed

Yin HH, Knowlton BJ (2006) The role of the basal ganglia in habit formation. Nat Rev Neurosci 7:464–476PubMed

Zanini S, Tavano A, Vorano L, Schiavo F, Gigli GL, Aglioti SM, Fabbro F (2004) Greater syntactic impairments in native language in bilingual Parkinsonian patients. J Neurol Neurosurg Psychiatry 75:1678–1681. doi:10.1136/jnnp.2003.018507

Titel: Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
verfasst von: Juan Felipe Cardona
Oscar Gershanik
Carlos Gelormini-Lezama
Alexander Lee Houck
Sebastian Cardona
Lucila Kargieman
Natalia Trujillo
Analía Arévalo
Lucia Amoruso
Facundo Manes
Agustín Ibáñez
Publikationsdatum: 01.11.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 6/2013
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-013-0510-1

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