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Neuroscience Bulletin
Erschienen in:

01.04.2019 | Review

Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies

verfasst von: Qiong-Bin Zhu, Ai-Min Bao, Dick Swaab

Erschienen in: Neuroscience Bulletin | Ausgabe 2/2019

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Abstract

Alzheimer’s disease (AD) is characterized by decreased neuronal activity and atrophy, while hyperactivity of neurons seems to make them resistant to aging and neurodegeneration, a phenomenon which we have paraphrased as ‘use it or lose it’. Our hypothesis proposes that (1) during their functioning, neurons are damaged; (2) accumulation of damage that is not repaired is the basis of aging; (3) the vulnerability to AD is determined by the genetic background and the balance between the amount of damage and the efficiency of repair, and (4) by stimulating the brain, repair mechanisms are stimulated and cognitive reserve is increased, resulting in a decreased rate of aging and risk for AD. Environmental stimulating factors such as bilingualism/multilingualism, education, occupation, musical experience, physical exercise, and leisure activities have been reported to reduce the risk of dementia and decrease the rate of cognitive decline, although methodological problems are present.
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Metadaten
Titel
Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies
verfasst von
Qiong-Bin Zhu
Ai-Min Bao
Dick Swaab
Publikationsdatum
01.04.2019
Verlag
Springer Singapore
Erschienen in
Neuroscience Bulletin / Ausgabe 2/2019
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-019-00340-5

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