Actual Sarcopenia Reflects Poor Prognosis in Patients with Esophageal Cancer
- 15.02.2022
- Thoracic Oncology
Erschienen in:
- Verfasst von
- Akihiro Watanabe, MD
- Taro Oshikiri, MD, PhD
- Ryuichiro Sawada, MD, PhD
- Hitoshi Harada, MD, PhD
- Naoki Urakawa, MD, PhD
- Hironobu Goto, MD
- Hiroshi Hasegawa, MD, PhD
- Shingo Kanaji, MD, PhD
- Kimihiro Yamashita, MD, PhD
- Takeru Matsuda, MD, PhD
- Daisuke Makiura, PhD
- Yoshihiro Kakeji, MD, PhD
- Erschienen in
- Annals of Surgical Oncology | Ausgabe 6/2022
Abstract
Background
Minimally invasive esophagectomy (MIE) for esophageal cancer patients with sarcopenia is associated with a high risk of perioperative complications; however, the relationship between sarcopenia and the survival of esophageal cancer patients remains controversial. In this study, we aimed to develop a stratifying marker for sarcopenia to precisely predict patients’ prognosis.
Methods
We retrospectively studied 135 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital from 2011 to 2015 and who were preoperatively diagnosed with or without sarcopenia based on the Asian Working Group for Sarcopenia index. Creatinine levels and albumin as measures of skeletal muscle volume and nutritional status, respectively, were used to develop a marker to be used for stratifying sarcopenic patients based on prognosis.
Results
Of the 135 patients, 35 were diagnosed with sarcopenia and 100 were not. We combined the creatinine and albumin levels (Cr × Alb) as a stratifying marker for sarcopenia, and extracted sarcopenic patients with values below the Cr × Alb cut-off as the actual sarcopenic group. The 5-year overall survival (OS) rates of the actual and non-actual sarcopenic groups were 28.9% and 58.9%, respectively (p = 0.0005), and the 5-year disease-free survival rate of the actual sarcopenic group was 34.1%, and 62.8% (p = 0.0106) for the non-actual sarcopenic group. This stratified sarcopenia model was an independent prognostic factor and was superior to sarcopenia alone for OS.
Conclusions
In patients undergoing MIE, preoperative measurement of Cr × Alb may be a prognostic stratification marker for patients with sarcopenia.
Anzeige
- Titel
- Actual Sarcopenia Reflects Poor Prognosis in Patients with Esophageal Cancer
- Verfasst von
-
Akihiro Watanabe, MD
Taro Oshikiri, MD, PhD
Ryuichiro Sawada, MD, PhD
Hitoshi Harada, MD, PhD
Naoki Urakawa, MD, PhD
Hironobu Goto, MD
Hiroshi Hasegawa, MD, PhD
Shingo Kanaji, MD, PhD
Kimihiro Yamashita, MD, PhD
Takeru Matsuda, MD, PhD
Daisuke Makiura, PhD
Yoshihiro Kakeji, MD, PhD
- Publikationsdatum
- 15.02.2022
- Verlag
- Springer International Publishing
- Erschienen in
-
Annals of Surgical Oncology / Ausgabe 6/2022
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681 - DOI
- https://doi.org/10.1245/s10434-022-11337-2
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
