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European Journal of Applied Physiology

Erschienen in:

07.11.2019 | Original Article

Acute hypotension attenuates brachial flow-mediated dilation in young healthy men

verfasst von: Erika Iwamoto, Yutaka Yamada, Masaki Katayose, Rintaro Sakamoto, Toru Neki, Jun Sugawara, Shigehiko Ogoh

Erschienen in: European Journal of Applied Physiology | Ausgabe 1/2020

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Abstract

Purpose

This study aimed to test our hypothesis that acute hypotension attenuates brachial flow-mediated dilation (FMD) as an index of endothelial function in healthy humans.

Methods

Twelve healthy men (21.8 ± 1.6 years, body mass index; 22.2 ± 1.6 kg/m²) participated in this study. Brachial FMD was measured in three trials: standardized FMD protocol (control trial), abrupt decrease in blood pressure (BP) via thigh cuff inflation–deflation (hypotension trial) and decrease in shear rate (SR) via a shortened forearm occlusion time (SR reduction trial). Brachial diameter and blood velocity were measured using Duplex ultrasound.

Results

Mean arterial pressure during reactive hyperaemia showed a marked decrease in the hypotension trial (− 23.7 ± 6.0 mmHg), but not in the control and SR reduction trials. SR area under the curve was attenuated in the SR reduction trial (P < 0.001), but not in the control and hypotension trials (P = 0.316). Consequently, FMD was attenuated in the hypotension and SR reduction trials compared with that in the control trial (P = 0.003 and P = 0.043, respectively), and was attenuated to a greater extent in the hypotension trial compared with the SR reduction trial (P = 0.006; control, 6.9 ± 3.5%; hypotension, 3.5 ± 1.7%; SR reduction, 5.0 ± 2.2%). After adjusting FMD using SR, FMD remained attenuated in the hypotension trial (P = 0.014), but not in the SR reduction trial.

Conclusion

Our findings indicate that arterial pressure as well as sympathetic nervous system activation could be an important determinant of FMD. Blunted FMD of peripheral arteries may be a rational response to restore BP and/or prevent further reduction of BP following acute hypotension in healthy humans.

Aaslid R, Lindegaard KF, Sorteberg W, Nornes H (1989) Cerebral autoregulation dynamics in humans. Stroke 20:45–52PubMed

Amiya E, Watanabe M, Komuro I (2014) The relationship between vascular function and the autonomic nervous system. Ann Vasc Dis 7:109–119PubMedPubMedCentral

Atkinson CL, Lewis NC, Carter HH, Thijssen DH, Ainslie PN, Green DJ (2015) Impact of sympathetic nervous system activity on post-exercise flow-mediated dilation in humans. J Physiol 593:5145–5156PubMedPubMedCentral

Bilfinger TV, Stefano GB (2000) Human aortocoronary grafts and nitric oxide release: relationship to pulsatile pressure. Ann Thorac Surg 69:480–485PubMed

Black MA, Cable NT, Thijssen DH, Green DJ (2008) Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51:203–210PubMed

Cahill PA, Redmond EM (2016) Vascular endothelium—gatekeeper of vessel health. Atherosclerosis 248:97–109PubMedPubMedCentral

Cheng TH, Shih NL, Chen SY, Loh SH, Cheng PY, Tsai CS, Liu SH, Wang DL, Chen JJ (2001) Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. J Mol Cell Cardiol 33:1805–1814PubMed

Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D, Seals DR (2005) Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation 111:494–498PubMed

Davies PF, Tripathi SC (1993) Mechanical stress mechanisms and the cell. An endothelial paradigm. Circ Res 72:239–245PubMed

Dehghan B, Sabri MR, Javanmard SH, Ahmadi AR, Mansourian M (2016) Neurally mediated syncope: is it really an endothelial dysfunction? Anatol J Cardiol 16:701–706PubMed

Dietz NM, Halliwill JR, Spielmann JM, Lawler LA, Papouchado BG, Eickhoff TJ, Joyner MJ (1997) Sympathetic withdrawal and forearm vasodilation during vasovagal syncope in humans. J Appl Physiol 82:1785–1793PubMed

Doshi SN, Naka KK, Payne N, Jones CJ, Ashton M, Lewis MJ, Goodfellow J (2001) Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clinic Sci 101:629–635

Dyson KS, Shoemaker JK, Hughson RL (2006) Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery. Am J Physiol Heart Circ Physiol 290:H1446–1453PubMed

Fadel PJ, Stromstad M, Hansen J, Sander M, Horn K, Ogoh S, Smith ML, Secher NH, Raven PB (2001) Arterial baroreflex control of sympathetic nerve activity during acute hypotension: effect of fitness. Am J Physiol Heart Circ Physiol 280:H2524–2532PubMed

Fox BM, Brantley L, White C, Seigler N, Harris RA (2014) Association between resting heart rate, shear and flow-mediated dilation in healthy adults. Exp Physiol 99:1439–1448PubMed

Galetta F, Franzoni F, Plantinga Y, Ghiadoni L, Merico G, Tocchini L, Braccini L, Rossi M, Carpi A, Taddei S, Santoro G (2006) Endothelial function in young subjects with vaso-vagal syncope. Biomed Pharmacother 60:448–452PubMed

Ghiadoni L, Donald AE, Cropley M, Mullen MJ, Oakley G, Taylor M, O'Connor G, Betteridge J, Klein N, Steptoe A, Deanfield JE (2000) Mental stress induces transient endothelial dysfunction in humans. Circulation 102:2473–2478PubMed

Ghiadoni L, Faita F, Salvetti M, Cordiano C, Biggi A, Puato M, Di Monaco A, De Siati L, Volpe M, Ambrosio G, Gemignani V, Muiesan ML, Taddei S, Lanza GA, Cosentino F (2012) Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study. J Hypertens 30:1399–1405PubMed

Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G (2011) Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension 57:363–369PubMed

Green DJ, Dawson EA, Groenewoud HM, Jones H, Thijssen DH (2014) Is flow-mediated dilation nitric oxide mediated? A meta-analysis. Hypertension 63:376–382PubMed

Harris KF, Matthews KA (2004) Interactions between autonomic nervous system activity and endothelial function: a model for the development of cardiovascular disease. Psychosom Med 66:153–164PubMed

Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ, Rabelink TJ (2002) Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol 39:683–688PubMed

Hinojosa-Laborde C, Ryan KL, Rickards CA, Convertino VA (2014) Resting sympathetic baroreflex sensitivity in subjects with low and high tolerance to central hypovolemia induced by lower body negative pressure. Front Physiol 5:241PubMedPubMedCentral

Hogarth AJ, Mackintosh AF, Mary DA (2007) Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects. Clin Sci 112:353–361PubMed

Iwamoto E, Bock JM, Casey DP (2018a) Blunted shear-mediated dilation of the internal but not common carotid artery in response to lower body negative pressure. J Appl Physiol 124:1326–1332PubMed

Iwamoto E, Bock JM, Casey DP (2018b) High-intensity exercise enhances conduit artery vascular function in older adults. Med Sci Sports Exerc 50:124–130PubMedPubMedCentral

Iwamoto E, Bock JM, Casey DP (2018c) Hypercapnia-induced shear-mediated dilation in the internal carotid artery is blunted in healthy older adults. Am J Physiol Heart Circ Physiol 315:H1279–H1286PubMed

Johnson JM, Rowell LB, Niederberger M, Eisman MM (1974) Human splanchnic and forearm vasoconstrictor responses to reductions of right atrial and aortic pressures. Circ Res 34:515–524PubMed

Jufri NF, Mohamedali A, Avolio A, Baker MS (2015) Mechanical stretch: physiological and pathological implications for human vascular endothelial cells. Vasc Cell 7:8 (eCollection 2015) PubMedPubMedCentral

Lepori M, Sartori C, Duplain H, Nicod P, Scherrer U (1999) Sympathectomy potentiates the vasoconstrictor response to nitric oxide synthase inhibition in humans. Cardiovasc Res 43:739–743PubMed

Lewis T (1932) A Lecture on vasovagal syncope and the carotid sinus mechanism. Br Med J 1:873–876PubMedPubMedCentral

Liao Y, Chen S, Liu X, Zhang Q, Ai Y, Wang Y, Jin H, Tang C, Du J (2010) Flow-mediated vasodilation and endothelium function in children with postural orthostatic tachycardia syndrome. Am J Cardiol 106:378–382PubMed

Lind L, Johansson K, Hall J (2002) The effects of mental stress and the cold pressure test on flow-mediated vasodilation. Blood Press 11:22–27PubMed

Ogoh S, Brothers RM, Eubank WL, Raven PB (2008) Autonomic neural control of the cerebral vasculature: acute hypotension. Stroke 39:1979–1987PubMed

Ogoh S, Lericollais R, Hirasawa A, Sakai S, Normand H, Bailey DM (2014) Regional redistribution of blood flow in the external and internal carotid arteries during acute hypotension. Am J Physiol Regul Integr Comp Physiol 306:R747–751PubMed

Ogoh S, Sorensen H, Hirasawa A, Sasaki H, Washio T, Hashimoto T, Bailey DM, Secher NH (2016) Dynamic cerebral autoregulation is unrelated to decrease in external carotid artery blood flow during acute hypotension in healthy young men. Exp Physiol 101:1040–1049PubMed

Padilla J, Johnson BD, Newcomer SC, Wilhite DP, Mickleborough TD, Fly AD, Mather KJ, Wallace JP (2008) Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus. Cardiovasc Ultrasound 6:44PubMedPubMedCentral

Park KH, Han SJ, Kim HS, Jo SH, Kim SA, Park WJ (2016) Endothelial function and cardiovascular autonomic activity in neurally mediated syncope. Cardiology 134:65–71PubMed

Pietrucha AZ (2014) Endothelial function in vasovagal syncope. Expert Rev Cardiovasc Ther 12:1387–1389PubMed

Pyke KE, Tschakovsky ME (2007) Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol 102:1510–1519PubMed

Ruiz GA, Sinigaglia S, Hermes R, Chirife R, Capula M, Perfetto JC, Tentori MC, Grancelli H, Nogues M (2010) Role of nitric oxide in young patients with vasovagal syncope. Europace 12:987–990PubMed

Sarkozi A, Cseh D, Gerlei Z, Kollai M (2018) Reduced neural baroreflex sensitivity is related to enhanced endothelial function in patients with end-stage liver disease. Scand J Gastroenterol 53:193–199PubMed

Sartori C, Lepori M, Scherrer U (2005) Interaction between nitric oxide and the cholinergic and sympathetic nervous system in cardiovascular control in humans. Pharmacol Ther 106:209–220PubMed

Spieker LE, Corti R, Binggeli C, Luscher TF, Noll G (2000) Baroreceptor dysfunction induced by nitric oxide synthase inhibition in humans. J Am Coll Cardiol 36:213–218PubMed

Tesfamariam B, Weisbrod RM, Cohen RA (1992) Cyclic GMP modulators on vascular adrenergic neurotransmission. J Vas Res 29:396–404

Thijssen DH, de Groot P, Kooijman M, Smits P, Hopman MT (2006) Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291:H3122–3129PubMed

Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ (2011) Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300:H2–12PubMed

Thijssen DH, Atkinson CL, Ono K, Sprung VS, Spence AL, Pugh CJ, Green DJ (2014) Sympathetic nervous system activation, arterial shear rate, and flow-mediated dilation. J Appl Physiol 116:1300–1307PubMed

Toda M, Yamamoto K, Shimizu N, Obi S, Kumagaya S, Igarashi T, Kamiya A, Ando J (2008) Differential gene responses in endothelial cells exposed to a combination of shear stress and cyclic stretch. J Biotechnol 133:239–244PubMed

Tymko MM, Tremblay JC, Steinback CD, Moore JP, Hansen AB, Patrician A, Howe CA, Hoiland RL, Green DJ, Ainslie PN (2017) UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude. J Appl Physiol 123:1386–1396PubMedPubMedCentral

Wagner AH, Kautz O, Fricke K, Zerr-Fouineau M, Demicheva E, Guldenzoph B, Bermejo JL, Korff T, Hecker M (2009) Upregulation of glutathione peroxidase offsets stretch-induced proatherogenic gene expression in human endothelial cells. Arterioscler Thromb Vasc Biol 29:1894–1901PubMed

Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL (1997) Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ Res 81:1–7PubMed

Titel: Acute hypotension attenuates brachial flow-mediated dilation in young healthy men
verfasst von: Erika Iwamoto
Yutaka Yamada
Masaki Katayose
Rintaro Sakamoto
Toru Neki
Jun Sugawara
Shigehiko Ogoh
Publikationsdatum: 07.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 1/2020
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-019-04260-0

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Acute hypotension attenuates brachial flow-mediated dilation in young healthy men

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Rauschtrinken in der frühen Adoleszenz

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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