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10.02.2020 | Original Article

Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid Valve

Zeitschrift:
Journal of Cardiovascular Translational Research
Autoren:
Garrett N. Coyan, Lindemberg da Mota Silveira-Filho, Yasumoto Matsumura, Samuel K. Luketich, William Katz, Vinay Badhwar, William R. Wagner, Antonio D’Amore
Wichtige Hinweise
Associate Editor Marat Fudim oversaw the review of this article

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12265-020-09960-z) contains supplementary material, which is available to authorized users.
Read at the 99th Annual Meeting of the American Association for Thoracic Surgery on May 5, 2019.

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Abstract

Degradable heart valves based on in situ tissue regeneration have been proposed as potentially durable and non-thrombogenic prosthetic alternatives. We evaluated the acute in vivo function, microstructure, mechanics, and thromboresistance of a stentless biodegradable tissue-engineered heart valve (TEHV) in the tricuspid position. Biomimetic stentless tricuspid valves were fabricated with poly(carbonate urethane)urea (PCUU) by double-component deposition (DCD) processing to mimic native valve mechanics and geometry. Five swine then underwent 24-h TEHV implantation in the tricuspid position. Echocardiography demonstrated good leaflet motion and no prolapse and trace to mild regurgitation in all but one animal. Histology revealed patches of proteinaceous deposits with no cellular uptake. SEM demonstrated retained scaffold microarchitecture with proteinaceous deposits but no platelet aggregation or thrombosis. Explanted PCUU leaflet thickness and mechanical anisotropy were comparable with native tricuspid leaflets. Bioinspired, elastomeric, stentless TEHVs fabricated by DCD were readily implantable and demonstrated good acute function in the tricuspid position.

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