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01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Journal of Medical Case Reports 1/2014

Acute kidney injury associated with minimal change disease in systemic lupus erythematosus: a case report

Journal of Medical Case Reports > Ausgabe 1/2014
Xin Wei, Ying Wang, Luxia Tu, Hongping Wan, Qinkai Chen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-8-422) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

XW was responsible for the case collection, case follow up and manuscript writing. YW contributed towards case collection and laboratory testing. LT and HW helped with the pathological diagnosis. Qinkai Chen contributed towards the case collection, clinical treatment and critical correction for the manuscript. All authors read and approved the final manuscript.



In systemic lupus erythematosus, acute kidney injury is usually associated with severe lupus nephritis and rarely associated with other glomerular diseases.

Case presentation

We recently encountered a patient with acute kidney injury that was associated with minimal change disease in systemic lupus erythematosus. A 26-year-old Chinese woman who had a history of systemic lupus erythematosus presented with nephrotic syndrome and acute kidney injury. She fulfilled four of the American College of Rheumatology criteria for the classification of systemic lupus erythematosus. However, a renal biopsy revealed that there were no glomerular abnormalities or deposition of immune complex. Her generalized edema disappeared, and her high serum creatinine level decreased to normal after prednisolone therapy.


Though the relationship between lupus and minimal change disease is still not defined, the possibility of systemic lupus erythematosus combined with minimal change disease must be differentiated in patients with lupus and severe proteinuria.

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