Skip to main content
Erschienen in: Zeitschrift für Rheumatologie 10/2014

01.12.2014 | Kasuistiken

Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus

verfasst von: P. Schjelderup, M.D., T.C. El-Galaly, J.B. Frøkjær, T. Ring

Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 10/2014

Einloggen, um Zugang zu erhalten

Abstract

We present a report of what we believe was an extremely rare case of hyperacute respiratory failure caused by first time exposure to cyclophosphamide in a 40-year-old woman with systemic lupus erythematosus. The patient was extensively evaluated for alternative etiologies with negative results. Treatment with methylprednisolone and high doses of human immunoglobulin resulted in gradual improvement of the patient’s condition. We review the literature with regard to cyclophosphamide-induced lung toxicity.
Literatur
1.
Zurück zum Zitat Houssiau FA, Vasconcelos C, D’Cruz D et al (2002) Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46:2121–2131PubMedCrossRef Houssiau FA, Vasconcelos C, D’Cruz D et al (2002) Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46:2121–2131PubMedCrossRef
2.
Zurück zum Zitat Emadi A, Jones RJ, Brodsky RA (2009) Cyclophosphamide and cancer: golden anniversary. Nat Rev Clin Oncol 6:638–647PubMedCrossRef Emadi A, Jones RJ, Brodsky RA (2009) Cyclophosphamide and cancer: golden anniversary. Nat Rev Clin Oncol 6:638–647PubMedCrossRef
3.
Zurück zum Zitat Stott H, Stephens R, Fox W et al (1976) An investigation of the chest radiographs in a controlled trial of busulphan, cyclophosphamide, and a placebo after resection for carcinoma of the lung. Thorax 31:265–270PubMedCentralPubMedCrossRef Stott H, Stephens R, Fox W et al (1976) An investigation of the chest radiographs in a controlled trial of busulphan, cyclophosphamide, and a placebo after resection for carcinoma of the lung. Thorax 31:265–270PubMedCentralPubMedCrossRef
4.
Zurück zum Zitat Malik SW, Myers JL, DeRemee RA, Specks U (1996) Lung toxicity associated with cyclophosphamide use. Two distinct patterns. Am J Respir Crit Care Med 154:1851–1856PubMedCrossRef Malik SW, Myers JL, DeRemee RA, Specks U (1996) Lung toxicity associated with cyclophosphamide use. Two distinct patterns. Am J Respir Crit Care Med 154:1851–1856PubMedCrossRef
5.
Zurück zum Zitat Burke DA, Stoddart JC, Ward MK, Simpson CG (1982) Fatal pulmonary fibrosis occurring during treatment with cyclophosphamide. Br Med J (Clin Res Ed) 285:696CrossRef Burke DA, Stoddart JC, Ward MK, Simpson CG (1982) Fatal pulmonary fibrosis occurring during treatment with cyclophosphamide. Br Med J (Clin Res Ed) 285:696CrossRef
6.
Zurück zum Zitat Patel AR, Shah PC, Rhee HL et al (1976) Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer 38:1542–1549PubMedCrossRef Patel AR, Shah PC, Rhee HL et al (1976) Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer 38:1542–1549PubMedCrossRef
7.
Zurück zum Zitat Gross DC, Sasaki TM, Buick MK, Light JA (1997) Acute respiratory failure and pulmonary fibrosis secondary to administration of mycophenolate mofetil. Transplantation 64:1607–1609PubMedCrossRef Gross DC, Sasaki TM, Buick MK, Light JA (1997) Acute respiratory failure and pulmonary fibrosis secondary to administration of mycophenolate mofetil. Transplantation 64:1607–1609PubMedCrossRef
8.
Zurück zum Zitat Morrissey P, Gohh R, Madras P, Monaco AP (1998) Pulmonary fibrosis secondary to administration of mycophenolate mofetil. Transplantation 65:1414PubMedCrossRef Morrissey P, Gohh R, Madras P, Monaco AP (1998) Pulmonary fibrosis secondary to administration of mycophenolate mofetil. Transplantation 65:1414PubMedCrossRef
9.
Zurück zum Zitat Kamen DL, Strange C (2010) Pulmonary manifestations of systemic lupus erythematosus. Clin Chest Med 31:479–488PubMedCrossRef Kamen DL, Strange C (2010) Pulmonary manifestations of systemic lupus erythematosus. Clin Chest Med 31:479–488PubMedCrossRef
Metadaten
Titel
Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus
verfasst von
P. Schjelderup, M.D.
T.C. El-Galaly
J.B. Frøkjær
T. Ring
Publikationsdatum
01.12.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Zeitschrift für Rheumatologie / Ausgabe 10/2014
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI
https://doi.org/10.1007/s00393-014-1381-4

Weitere Artikel der Ausgabe 10/2014

Zeitschrift für Rheumatologie 10/2014 Zur Ausgabe

Empfehlungen und Stellungnahmen von Fachgesellschaften

Empfehlungen zum Einsatz von Abatacept bei Patienten mit rheumatoider Arthritis

Mitteilungen der DRL

Mitteilungen der DRL

Mitteilungen der DGRh

Mitteilungen

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.