Background
Methods
Results
Variables | HIV patients who completed the ABQ-HIV | HIV patients who did not complete the ABQ-HIV | P-values |
---|---|---|---|
N
| 370 | 25 | |
Age in years – mean (SD) | 51.2 (1.0) | 55.8 (15.5) | 0.031 |
Female gender – n (%) | 58 (15.7%) | 5 (20.0%) | < 0.001 |
Duration since first HIV diagnosis in years – mean (SD) | 11.7 (0.3) | 10.3 (6.1) | 0.466 |
Duration since first HIV treatment in years – mean (SD) | 8.7 (0.2) | 8.6 (5.7) | 0.829 |
Country of origin – n (%) | 0.464 | ||
Germany | 326 (88.1%) | 21 (84.0%) | |
Othera | 41 (11.1%) | 4 (16.0%) | |
Not specified | 3 (0.81%) | 0 (0.0%) | |
Education level – n (%) | 0.622 | ||
No degree | 24 (6.5%) | 3 (12.0%) | |
Apprenticeship | 208 (56.2%) | 17 (68.0%) | |
High school degree | 42 (11.4%) | 2 (8.0%) | |
University degree | 87 (23.5%) | 3 (12.0%) | |
Other | 2 (0.5%) | 0 (0.0%) | |
Not specified | 4 (1.1%) | 0 (0.0%) | |
Employment status – n (%) | 0.167 | ||
Employed | 240 (64.9%) | 14 (56.0%) | |
Unemployed | 45 (12.2%) | 1 (4.0%) | |
Pensioner/other | 81 (21.9%) | 10 (40.0%) | |
Not specified | 2 (0.5%) | 0 (0.0%) | |
Most common treatment regimens – n (%) | |||
Tenofovir alafenamide + emtricitabine + elvitegravir | 65 (17.6%) | 2 (8.0%) | |
Lamivudine + abacavir + dolutegravir | 58 (15.7%) | 4 (16.0%) | |
Tenofovir alafenamide + emtricitabine + rilpivirine | 42 (11.4%) | 0 (0.0%) | |
Tenofovir disoproxil + emtricitabine + efavirenz | 41 (11.1%) | 2 (8.0%) | |
Number of tablets patients needed to take per day (reported by the patient) – n (%) | 0.906 | ||
Not specified | 6 (1.6%) | 2 (8.0%) | |
1–3 | 237 (64.1%) | 14 (56.0%) | |
3–5 | 67 (18.1%) | 4 (16.0%) | |
5–10 | 60 (16.2%) | 5 (20.0%) |
Item properties
Reliability
Item | 17-item ABQ-HIV (Cronbach’s α: 0.708) | 15-item ABQ-HIV (Cronbach’s α: 0.720) | ||
---|---|---|---|---|
Item-total correlation coefficient | Cronbach’s α if item is deleted | Item-total correlation coefficient | Cronbach’s α if item is deleted | |
Item 1: “I fully understand what my doctor, nurse or pharmacist has explained to me regarding my medication therapy.” | 0.291 | 0.701 | 0.289 | 0.715 |
Item 2: “I can mention the names of my medicines and their scope without hesitation.” | 0.302 | 0.695 | 0.308 | 0.708 |
Item 3: “I trust my doctor and agree on my therapy plan together with him.” | 0.254 | 0.704 | 0.228 | 0.718 |
Item 4: “My medications only help me if I take them on a strict regular basis.” | 0.207 | 0.705 | 0.193 | 0.719 |
Item 5: “Medicines are all poisonous. You should avoid taking medicines at all if possible.” | 0.352 | 0.689 | 0.364 | 0.702 |
Item 6: “I feel basically healthy. Therefore, I am sometimes unsure whether I really have to take my medicines daily.” | 0.273 | 0.699 | 0.286 | 0.712 |
Item 7: “I take my medicines automatically at a fixed time or on fixed occasions every day (e.g. at meal times, before going to bed).” | 0.284 | 0.698 | 0.265 | 0.713 |
Item 8: “I feel that co-payments for medication are a great burden.” | 0.370 | 0.687 | 0.399 | 0.697 |
Item 9: “Generally, I find it unpleasant when other people notice my medication intake.” | 0.273 | 0.701 | 0.254 | 0.720 |
Item 10: “I frequently forget things on a daily basis.” | 0.439 | 0.679 | 0.461 | 0.690 |
Item 11: “Generally, I often feel bad, and sometimes I feel discouraged and depressed.” | 0.440 | 0.677 | 0.446 | 0.690 |
Item 12: “I frequently have problems taking my medications (e.g. swallowing, opening the package, dividing the tablets) or it is difficult for me to adhere to the accompanying conditions of the medication intake (e.g. on an empty stomach, with food or alcohol restrictions).” | 0.437 | 0.682 | 0.440 | 0.694 |
Item 13: “I have difficulties adhering to my treatment plan, especially when I am away from home (e.g. at weekends, on business trips or holidays).” | 0.488 | 0.676 | 0.461 | 0.691 |
Item 14: “I receive great support from my family members/friends, who I can talk to at any time and ask for help.” | 0.120 | 0.720 | – | – |
Item 15: “I am really frightened about the side effects of my medicines.” | 0.376 | 0.686 | 0.387 | 0.698 |
Item 16: “In case I have already noticed or in case I were to notice side effects related to my medicines: I have talked or would talk to my doctor about them as soon as possible.” | 0.159 | 0.707 | – | – |
Item 17: “In case I have already noticed or in case I were to notice side effects related to my medicines: I have stopped/would stop taking my medications or took/would take less of them.” | 0.189 | 0.706 | 0.199 | 0.720 |
Factor analysis
Component 1 “Unintentional” | Component 2 “Knowledge” | Component 3 “Intentional” | |
---|---|---|---|
Eigenvalue | 3.313 | 1.329 | 1.314 |
Variance explained | 22.086% | 8.860% | 8.759% |
Possible range of subscale score | 7–28 | 5–20 | 3–12 |
Observed range of subscale score | 7–27 | 5–11 | 3–12 |
N (%) of patients with at least one barrier | 284 (76.8%) | 38 (10.3%) | 141 (38.1%) |
Items | |||
Item 1: “I fully understand what my doctor, nurse or pharmacist has explained to me regarding my medication therapy.” | 0.642 | ||
Item 2: “I can mention the names of my medicines and their scope without hesitation.” | 0.478 | ||
Item 3: “I trust my doctor and agree on my therapy plan together with him.” | 0.696 | ||
Item 4: “My medications only help me if I take them on a strict regular basis.” | 0.496 | ||
Item 5: “Medicines are all poisonous. You should avoid taking medicines at all if possible.” | 0.563 | ||
Item 6: “I feel basically healthy. Therefore, I am sometimes unsure whether I really have to take my medicines daily.” | 0.749 | ||
Item 7: “I take my medicines automatically at a fixed time or on fixed occasions every day (e.g. at meal times, before going to bed).” | 0.477 | ||
Item 8: “I feel that co-payments for medication are a great burden.” | 0.460 | ||
Item 9: “Generally, I find it unpleasant when other people notice my medication intake.” | 0.554 | ||
Item 10: “I frequently forget things on a daily basis.” | 0.613 | ||
Item 11: “Generally, I often feel bad, and sometimes I feel discouraged and depressed.” | 0.651 | ||
Item 12: “I frequently have problems taking my medications (e.g. swallowing, opening the package, dividing the tablets) or it is difficult for me to adhere to the accompanying conditions of the medication intake (e.g. on an empty stomach, with food or alcohol restrictions).” | 0.568 | ||
Item 13: “I have difficulties adhering to my treatment plan, especially when I am away from home (e.g. at weekends, on business trips or holidays).” | 0.468 | ||
Item 15: “I am really frightened about the side effects of my medicines.” | 0.639 | ||
Item 17: “In case I have already noticed or in case I were to notice side effects related to my medicines: I have stopped/would stop taking my medications or took/would take less of them.” | 0.693 |
Convergent validity
ABQ total score of reduced scale | Component 1 “Unintentional” | Component 2 “Knowledge” | Component 3 “Intentional” | |
---|---|---|---|---|
Correlation (p-value) with the total score of MMASa-items | −0.422 (p < 0.001) | −0.396 (p < 0.001) | −0.353 (p < 0.001) | − 0.171 (0.001) |
Mean ABQ-HIV for patients … | ||||
… with at least medium adherence (MMAS score = > 6) | 24.01 | 13.27 | 5.76 | 4.97 |
…. with low adherence (MMAS score < 6) | 29.60 | 17.00 | 6.84 | 5.65 |
p-value | < 0.001 | < 0.001 | < 0.001 | 0.053 |