Skip to main content
main-content

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Diagnostic Pathology 1/2017

ADAR1 overexpression is associated with cervical cancer progression and angiogenesis

Zeitschrift:
Diagnostic Pathology > Ausgabe 1/2017
Autoren:
Ying Chen, He Wang, Wenyi Lin, Ping Shuai
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s13000-017-0600-0) contains supplementary material, which is available to authorized users.

Abstract

Background

This study aimed to assess the role of RNA-dependent adenosine deaminase (ADAR1) in cervical squamous cell carcinoma occurrence and progression.

Methods

ADAR1 expression levels in stage IA and stage IIA cervical squamous cell carcinoma (group A), cervical intraepithelial neoplasia (CIN) specimens (group B), as well as normal and inflamed cervical tissue samples (group C) were assessed by immunohistochemistry. Clinical and pathological data of cervical squamous cell carcinoma patients undergoing surgery were retrospectively evaluated. Chi-square test, comparative analysis of survival curve, disease-free survival and COX risk assessment method were used to understand the association of ADAR1 with the occurrence and progression and prognostic significance of cervical squamous cell carcinoma.

Results

ADAR1 is expressed in the cytoplasm and nuclei. The expression level was high in squamous cell carcinoma tissues (81.18%), while relatively low in the CIN group (21.56%). And there was no expression in non-cancerous tissues. The differences between them were statistically significant using P < 0.05 as criterion. One-factor analysis revealed that ADAR1 was significantly correlated with tumor diameter, horizontal diffusion diameter, vascular invasion, parametrial invasion, vaginal involvement, and pathologically diagnostic criteria for perineural invasion (PNI). Meanwhile, the overall survival rate of ADAR1 positive patients was significantly lower compared with that of patients with no ADAR1 expression (P < 0.05). Analysis also showed that disease-free survival time of ADAR1 positive patients was shorter than that of ADAR1 negative patients, and the difference was significant (P < 0.01). Finally, COX risk assessment showed that parametrical invasion had independent prognostic factors for overall survival of squamous cell carcinoma.

Conclusions

Results indicated that ADAR1 might play an important role in the occurrence, progression and prognosis of cervical squamous cancer.
Zusatzmaterial
Additional file 1: Original data of baseline, clinical pathological diagnosis, prognosis and follow-up for ADAR1 patients. (DOC 825 kb)
13000_2017_600_MOESM1_ESM.doc
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Diagnostic Pathology 1/2017 Zur Ausgabe

Neu im Fachgebiet Pathologie

22.10.2019 | Schwerpunkt: Seltene Erkrankungen | Ausgabe 6/2019

Die IgG4-assoziierte Erkrankung

Mikroskopische Diagnose und Differenzialdiagnose

02.10.2019 | Schwerpunkt: Seltene Erkrankungen | Ausgabe 6/2019

Das un- und dedifferenzierte Endometriumkarzinom

Eine seltene Entität mit breitem differenzialdiagnostischem Spektrum