Erschienen in:
02.02.2016 | Original Paper
Adherence and Acceptability of a Multidrug Vaginal Ring for HIV Prevention in a Phase I Study in the United States
verfasst von:
Ariane van der Straten, Lori Panther, Nicole Laborde, Craig J. Hoesley, Helen Cheng, Marla J. Husnik, Stephanie Horn, Annalene Nel, Lydia Soto-Torres, Beatrice A. Chen
Erschienen in:
AIDS and Behavior
|
Ausgabe 11/2016
Einloggen, um Zugang zu erhalten
Abstract
We evaluated the adherence and acceptability of a vaginal ring containing dapivirine, maraviroc, or both drugs for 28 days during a Phase I placebo-controlled trial in 48 HIV-negative sexually abstinent U.S. women aged 18–40. Adherence was assessed weekly by clinical interview and computer-assisted self-interviewing; acceptability assessment occurred at the last product-use visit. Study retention was 98 % (47/48); 94 % (45/48) reported being fully adherent with ring use during the 28-day period. Two participants experienced the ring partially coming out. Analysis was blinded and behavioral data were combined across study groups. Most women reported being very comfortable having the ring in their vagina; 44 % preferred continuous use, whereas 51 % had no preference compared to episodic use. Although a range of minor ring concerns were expressed, few were actually experienced. High adherence to and acceptability of this vaginal ring in this Phase I trial contributes to its promise as a sustained mechanism for multidrug vaginal microbicide delivery.