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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Adipocytokine levels mark endothelial function in normotensive individuals

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Anna Solini, Francesco Stea, Eleonora Santini, Rosa Maria Bruno, Emiliano Duranti, Stefano Taddei, Lorenzo Ghiadoni
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-103) contains supplementary material, which is available to authorized users.

Competing interests

L. Ghiadoni is councilor of Quipu s.r.l, Pisa, Italy.

Authors’ contributions

AS designed the study and wrote the paper; FS and RMB recruited the patients and performed the studies; ES and ED performed the lab work; ST revised the paper; LG designed the study, analyzed data and contributed to write the paper. All authors read and approved the final manuscript.

Abstract

Background

Endothelial dysfunction is an independent risk factor for cardiovascular events. Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction. This study addressed the relationship of adipocytokines with endothelial function and blood pressure.

Methods

In 92 newly diagnosed, drug-naïve essential hypertensive patients (HT, mean age 49 yrs) without organ damage and 66 normotensive subjects (NT, mean age 47 yrs), by an automated system, we measured endothelium-dependent and -independent vasodilation as brachial artery flow-mediated dilation before and after administration of glyceryl-trinitrate. Retinol binding protein-4 (RBP4) and resistin levels were determined by ELISA and RIA, respectively. Oxidative stress was evaluated by measuring serum malondyaldehyde (MDA).

Results

Flow-mediated dilation was significantly (p = 0.03) lower in HT (5.3 ± 2.6%) than NT (6.1 ± 3.1%), while response to glyceryl-trinitrate (7.5 ± 3.7% vs 7.9 ± 3.4%) was similar. RBP4 (60.6 ± 25.1 vs 61.3 ± 25.9 μg/ml), resistin (18.8 ± 5.3 vs 19.9 ± 6.1 ng/ml) and MDA levels (2.39 ± 1.26 vs 2.08 ± 1.17 nmol/ml) were not different in HT and NT. RBP4 (r = −0.25; p = 0.04) and resistin levels (r = −0.29; p = 0.03) were related to flow-mediated dilation in NT, but not in HT (r = −0.03 and r = −0.10, respectively). In NT, multivariate analysis including RBP4 and confounders showed that only BMI or waist circumference remained related to flow- mediated dilation. In the multivariate model including resistin and confounders, BMI, age and resistin were significantly related to flow-mediated dilation, while only age significant correlated with this parameter when BMI was replaced by waist circumference.

Conclusions

Adipocytokine levels may be independent predictors of endothelial dysfunction in the peripheral circulation of healthy subjects, providing a pathophysiological link between inflammation from adipose tissue and early vascular alterations.
Zusatzmaterial
Authors’ original file for figure 1
12933_2012_548_MOESM1_ESM.tiff
Authors’ original file for figure 2
12933_2012_548_MOESM2_ESM.tiff
Authors’ original file for figure 3
12933_2012_548_MOESM3_ESM.tiff
Literatur
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