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Current Hypertension Reports

Erschienen in:

01.11.2018 | Hypertension and Metabolic Syndrome (J Sperati, Section Editor)

Adipose Tissue and Modulation of Hypertension

verfasst von: Eashita Das, Joon Ho Moon, Ju Hee Lee, Nikita Thakkar, Zdenka Pausova, Hoon-Ki Sung

Erschienen in: Current Hypertension Reports | Ausgabe 11/2018

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Abstract

Purpose of Review

Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN.

Recent Findings

Adipose tissue provides mechanical protection of the blood vessels and plays a role in regulation of vascular tone. Exercise and fasting activate BAT and induce browning of white adipose tissue (WAT). BAT-secreted FGF21 lowers BP and protects against HTN. Browning of perivascular WAT improves HTN.

Summary

New insights on WAT browning and BAT activation can open new avenues of potential therapeutic interventions to treat obesity-related HTN.

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Titel: Adipose Tissue and Modulation of Hypertension
verfasst von: Eashita Das
Joon Ho Moon
Ju Hee Lee
Nikita Thakkar
Zdenka Pausova
Hoon-Ki Sung
Publikationsdatum: 01.11.2018
Verlag: Springer US
Erschienen in: Current Hypertension Reports / Ausgabe 11/2018
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-018-0894-7

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Weitere Artikel der Ausgabe 11/2018

Skin Sodium and Hypertension: a Paradigm Shift?

Catheter-Based Renal Denervation for Hypertension

Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials

Modulation of Sympathetic Overactivity to Treat Resistant Hypertension

SPRINT and the Kidney: What Have We Learned?

Chronotherapy for Hypertension

Leitlinien kompakt für die Innere Medizin

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Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin