The authors declare that there are no conflicts of interests.
All authors have contributed significantly and all authors are in agreement concerning the content of the manuscript. YB and ZZ evaluated the researches independently. YB drafted the manuscript. All authors read and approved the final manuscript.
Endometrial cancer is a common female malignancy. Patients with high-risk endometrial cancer have relatively high incidence of metastasis and recurrence. Despite complete resection, patients with stage III or IV are at high risk of local or distant recurrence. Systemic adjuvant treatment includes chemotherapy and radiotherapy. But the optimal scheduling is not known. Recently proposed sequential chemo-radiotherapy as sandwich therapy for high risk endometrial cancer have yielded encouraging results. This article is to review the adjuvant chemo-radiotherapy in the “sandwich” method for high risk endometrial cancer to help clinicians identify the most effective adjuvant treatment for patients with high risks of it.
We used MEDLINE, EMBASE, Cochrane Library and CBM databases to search the literature.
A systematic review was made. And most data showed “sandwich” therapy is feasible, efficacious, well-tolerated and resulted in excellent long-term progression free and overall survival in the setting of advanced endometrial cancer.
Randomized trials are necessary to compare chemo-radio therapy given in the “sandwich” fashion to other means of sequencing these treatment modalities. It is also necessary to define which population is best suited for “sandwich” adjuvant therapy.
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Lan C, Huang X, Cao X, Huang H, Feng Y, Huang Y, et al. Adjuvant docetaxel and carboplatinchemotherapy administered alone or with radiotherapy in a “sandwich” protocol in patients with advanced endometrial cancer: a single-institution experience. Expert Opin Pharmacother. 2013;14:535–42. CrossRefPubMed
- Adjuvant chemo-radiotherapy in the “sandwich” method for high risk endometrial cancer—a review of literature
- BioMed Central
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