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Erschienen in: Journal of Gastrointestinal Surgery 12/2023

21.11.2023 | Original Article

Adjuvant Radiotherapy Is Not Necessary for Stage III Mucinous Rectal Cancer: Evidence Based on Long Survival Analysis from SEER Data

verfasst von: Hualin Liao, Cheng Tang, Zhen Zhou, Haoran Shi, Tao Li, Yahang Liang, Mingming Li, Taiyuan Li, Xiong Lei

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 12/2023

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Abstract

Background

Although rectal mucinous adenocarcinoma (RMC) is less sensitive to radiotherapy, adjuvant radiotherapy is still recommended for RMC patients. This study aimed to explore whether adjuvant radiotherapy is necessary for stage III RMC.

Methods

Data of patients with stage III RMC were obtained from the National Cancer Institute’s SEER database (2004–2015). The survival rates were calculated by Kaplan–Meier method and compared by log-rank test. Univariate and multivariate Cox regression analyses were used to assess the impact of clinicopathological parameters on overall survival (OS) and cancer-specific survival (CSS).

Results

RMC has a worse T and N stage at diagnosis than rectal adenomatous carcinoma (RAC) (all p < 0.001). Multivariate Cox regression analyses revealed that histopathological type MC was an independent poor prognostic factor for OS (HR 1.27; 95%CI 1.14–1.41; p < 0.001) and CSS (HR 1.34; 95%CI 1.18–1.51; p < 0.001). Subgroup analysis based on different treatment regimens showed no significant difference between chemotherapy group and chemotherapy plus radiotherapy group. After the propensity score matching, no significant difference was also found in OS and CSS between chemotherapy group and chemotherapy plus radiotherapy group.

Conclusions

RMC is an independent poor prognostic factor for OS and CSS. Adjuvant radiotherapy for RMC was not beneficial in improving survival outcomes.
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Metadaten
Titel
Adjuvant Radiotherapy Is Not Necessary for Stage III Mucinous Rectal Cancer: Evidence Based on Long Survival Analysis from SEER Data
verfasst von
Hualin Liao
Cheng Tang
Zhen Zhou
Haoran Shi
Tao Li
Yahang Liang
Mingming Li
Taiyuan Li
Xiong Lei
Publikationsdatum
21.11.2023
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Surgery / Ausgabe 12/2023
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-023-05765-y

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